CAS 60239-18-1

DOTA

Description:

DOTA, or 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid, is a polyaminocarboxylic acid that serves as a chelating agent, particularly in coordination chemistry and radiopharmaceutical applications. Its structure features a cyclic framework with four nitrogen atoms and four carboxylic acid groups, allowing it to effectively bind metal ions, such as gallium, indium, and lutetium. DOTA is known for its stability and ability to form strong complexes, making it valuable in medical imaging and targeted radiotherapy. The compound is typically used in the labeling of biomolecules for positron emission tomography (PET) and single-photon emission computed tomography (SPECT). DOTA's solubility in water and compatibility with biological systems enhance its utility in various biochemical applications. Additionally, its ability to form stable complexes with radionuclides allows for precise targeting in cancer treatment, highlighting its significance in both research and clinical settings. Overall, DOTA is a versatile compound with important implications in the fields of chemistry, medicine, and radiopharmaceutical development.

Formula: C₁₆H₂₈N₄O₈

InChI: InChI=1/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)

InChI key: InChIKey=WDLRUFUQRNWCPK-UHFFFAOYSA-N

SMILES: C(C(O)=O)N1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1

Synonyms:

• 1,4,7,10-Tetra(carboxymethyl)-1,4,7,10-tetraazacyclododecane
• 1,4,7,10-Tetraazacyclodecane-1,4,7,10-tetraacetic acid
• 1,4,7,10-Tetraazacyclododecane-N,N′,N′′,N′′′-tetraacetic acid
• 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetrayl)Tetraacetic Acid
• 2-[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
• Dota
• NSC 681107
• Tetraxetan
• 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
• TETRAAZA-12-CROWN-4 TETRAACETIC ACID AMMONIUM SALT (SEE 2923)
• DOTA(M-140)
• 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid >=97.0% (CHN)
• 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakisacetic acid
• 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID, FREE ACID
• 1,4,7,10-TETRAAZACYCLODODECANE-N,N'',N , N''-TETRAACETIC ACID , (DOTA)
• 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetrakisacetic acid
• Tetraxetan/radical
• 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetraacetic acid
• TetraxetanuM
• 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraaceticacid,min.98%DOTA
• 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane
• 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID DOTA
• Tetraxetanum (DOTA)
• Tetraxetan/DOTA/1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
• -1,4,7,10-tetrayl)tetraacetic acid(DOTA)
• TETRAAZA-12-CROWN-4-1,4,7,10-TETRAACETIC ACID
• 4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid
• 1,4,7,10-Tetraazacyclododecan-N,N',N,N'-tetraacetic acid
• 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid

CAS: 60239-18-1

Formula: C₁₆H₂₈N₄O₈

Purity: >97.0%(T)

Color and Shape: White to Almost white powder to crystaline

Molecular weight: 404.42

Ref: 3B-T1875

1,4,7,10-Tetraazacyclo­dodecane-N,N',N'',N'''-tetraacetic acid, min. 98% DOTA

CAS: 60239-18-1

1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid, min. 98% DOTA

Formula: C₁₆H₂₈N₄O₈

Purity: min. 98%

Color and Shape: white pwdr.

Molecular weight: 404.42

Ref: 08-07-1942

Tetraxetan

CAS: 60239-18-1

Heterocyclic compounds (excluding aromatic or modified aromatic) withnitrogen hetero-atom(s) only nesoi

Formula: C₁₆H₂₈N₄O₈

Color and Shape: White Off-White Powder

Molecular weight: 404.19071

Ref: 45-1652158

DOTA

CAS: 60239-18-1

Formula: C₁₆H₂₈N₄O₈

Purity: 95%

Color and Shape: Solid

Molecular weight: 404.4155

Ref: IN-DA00E8U5

Tetraxetan

CAS: 60239-18-1

Tetraxetan

Purity: 98%

Molecular weight: 404.42g/mol

Ref: 54-OR74571

Tetraxetan

CAS: 60239-18-1

Color and Shape: Neat

Ref: 86-MM3916.00

Gadobutrol Impurity 9

CAS: 60239-18-1

Formula: C₁₆H₂₈N₄O₈

Molecular weight: 404.42

Ref: 4Z-G-3113

Gadoteridol Impurity 2

CAS: 60239-18-1

Formula: C₁₆H₂₈N₄O₈

Molecular weight: 404.42

Ref: ST-EA-CP-G4004

DOTA

Controlled Product

CAS: 60239-18-1

Stability Hygroscopic
Applications Bifunctional DOTA conjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and therapeutic radiopharmaceuticals.
References Lewis, M., et al.: Bioconjug. Chem., 9, 72 (1998), Chappell, L., et al.: Bioorg. Med. Chem., 7, 2313 (1999), Prantner, A., et al.: Mol. Imaging, 2, 333 (2003), Allen, M., et al.: Chem. Biol., 11, 301 (2004), Weiner, R., et al.: BioDrugs, 19, 145 (2005), Breeman, W., et al.: Radionuclide Peptide Cancer Therapy, 119 (2006),

Formula: C₁₆H₂₈N₄O₈

Color and Shape: Light Yellow

Molecular weight: 404.42

Ref: TR-D535500

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid

CAS: 60239-18-1

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a metal chelator or radioligand that is used for the diagnosis of cancer. DOTA, as other analogous compounds such as NOTA, TETA and DTPA, has a high affinity for gadolinium and binds to integrin receptors on the surface of cancer cells. It can then be detected by nuclear magnetic resonance spectroscopy or computed tomography. This agent is also used in conjunction with other drugs to treat certain cancers. The most common use of DOTA is as a component of chemotherapy drugs such as docetaxel and cisplatin. DOTA has been shown to be biocompatible with human serum and metabolic response studies have been conducted in animals without any serious side effects. DOTA has shown to be an effective anti-cancer drug for solid tumors in animals and humans with minimal toxicity due to its coordination geometry.

Formula: C₁₆H₂₈N₄O₈

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 404.42 g/mol

Ref: 3D-FT58676

Tetraxetan

CAS: 60239-18-1

Purity: 95%

Molecular weight: 404.4200134

Ref: 10-F602191

Tetraxetan

CAS: 60239-18-1

Tetraxetan is a useful organic compound for research related to life sciences. The catalog number is T65143 and the CAS number is 60239-18-1.

Formula: C₁₆H₂₈N₄O₈

Color and Shape: Solid

Molecular weight: 404.42

Ref: TM-T65143