CAS 60254-83-3

(Des-Tyr1)-Leu-Enkephalin

Description:

(Des-Tyr1)-Leu-Enkephalin, also known as a synthetic peptide, is a derivative of the naturally occurring enkephalins, which are endogenous opioid peptides. This compound is characterized by its structure, which includes a sequence of amino acids that contribute to its biological activity. It is specifically designed to have a modified structure, lacking the tyrosine residue at the first position, which influences its binding affinity and potency at opioid receptors. The substance primarily interacts with the delta-opioid receptor, playing a role in pain modulation and analgesia. Its pharmacological properties make it of interest in research related to pain management and the development of new analgesic drugs. Additionally, (Des-Tyr1)-Leu-Enkephalin is often studied for its potential neuroprotective effects and its role in various physiological processes. As a synthetic compound, it is typically used in laboratory settings for research purposes rather than for therapeutic applications in humans. Safety and handling precautions are essential when working with this substance, as with any peptide or chemical compound.

Formula: C₁₉H₂₈N₄O₅

InChI: InChI=1/C19H28N4O5/c1-12(2)8-15(19(27)28)23-18(26)14(9-13-6-4-3-5-7-13)22-17(25)11-21-16(24)10-20/h3-7,12,14-15H,8-11,20H2,1-2H3,(H,21,24)(H,22,25)(H,23,26)(H,27,28)/t14-,15-/m0/s1

SMILES: CC(C)C[C@@H](C(=O)O)N=C([C@H](Cc1ccccc1)N=C(CN=C(CN)O)O)O

Synonyms:

• H-Gly-Gly-Phe-Leu-OH
• Glycylglycylphenylalanylleucine
• glycylglycyl-L-phenylalanyl-L-leucine
• des-tyr(1)-enkephalin-le
• GLY-GLY-PHE-LEU
• L-Leucine, glycylglycyl-L-phenylalanyl-
• (DES-TYR1)-LEU-ENKEPHALIN
• enkephalin-Leu, des-Tyr(1)-
• D Leu-Enkephalin
• NSC 350589
• [DES-TYR1,LEU5]-ENKEPHALIN
• (Des-Tyr1)-Leu-Enkephalin H-Gly-Gly-Phe-Leu-OH

(Des-Tyr1)-Leu-Enkephalin H-Gly-Gly-Phe-Leu-OH TFA Salt

Controlled Product

CAS: 60254-83-3

Applications (Des-Tyr1)-Leu-Enkephalin H-Gly-Gly-Phe-Leu-OH (CAS# 60254-83-3) is a useful research chemical compound.

Formula: C₁₉H₂₈N₄O₅·C₂HF₃O₂

Color and Shape: Neat

Molecular weight: 506.473

Ref: TR-D271430

(Des-Tyr1)-Leu-Enkephalin

CAS: 60254-83-3

Des-Tyr1-Leu-Enkephalin H-Gly-Gly-Phe-Leu-OH is a synthetic opioid peptide that acts as a neuroprotective agent and has been shown to enhance the expression of nerve growth factor. It also has immunomodulatory effects by interacting with opioid receptors and regulating the production of inflammatory cytokines. Des-Tyr1-Leu-Enkephalin H-Gly-Gly-Phe-Leu-OH binds to opioid receptors in the central nervous system, thereby triggering a response that leads to pain relief and suppression of cough reflexes. This peptide has been shown to be effective in clinical trials for patients with neuropathic pain or postoperative ileus. It also shows promise as an analgesic for cancer patients with chronic pain, although this use is still experimental.

Formula: C₁₉H₂₈N₄O₅

Purity: Min. 95%

Molecular weight: 392.45 g/mol

Ref: 3D-FD111019