(Ala2)-leucine enkephalin, also known as a synthetic analog of the natural peptide enkephalins, is a pentapeptide that plays a significant role in the modulation of pain and the regulation of various physiological processes. Its structure consists of five amino acids, with alanine substituted for the first position of the natural leucine enkephalin sequence. This modification enhances its stability and potency as an opioid peptide. The compound primarily interacts with opioid receptors in the central nervous system, contributing to analgesic effects and influencing mood and stress responses. (Ala2)-leucine enkephalin is characterized by its relatively small size, which allows it to easily penetrate biological membranes. It is typically studied for its potential therapeutic applications in pain management and as a model for understanding opioid receptor interactions. Additionally, its synthesis and characterization involve techniques such as solid-phase peptide synthesis and mass spectrometry, ensuring purity and structural integrity for research purposes.

(ala2)-leucine enkephalin

60284-47-1: (Ala2)-leucine enkephalin, also known as a synthetic analog of the natural peptide enkephalins, is a pentapeptide that plays a significant role in the modulation of pain and the regulation of various physiological processes. Its structure consists of five amino acids, with alanine substituted for the first position of the natural leucine enkephalin sequence. This modification enhances its stability and potency as an opioid peptide. The compound primarily interacts with opioid receptors in the central nervous system, contributing to analgesic effects and influencing mood and stress responses. (Ala2)-leucine enkephalin is characterized by its relatively small size, which allows it to easily penetrate biological membranes. It is typically studied for its potential therapeutic applications in pain management and as a model for understanding opioid receptor interactions. Additionally, its synthesis and characterization involve techniques such as solid-phase peptide synthesis and mass spectrometry, ensuring purity and structural integrity for research purposes.

<p>Leu-enkephalin is an opioid peptide that is a neurotransmitter in the brain. It is synthesized from the proenkephalin precursor and acts on δ-opioid receptors and kappa-opioid receptors. Leu-enkephalin has been shown to have physiological effects such as analgesia, hypothermia, hyperalgesia, and decreased gastrointestinal motility. Leu-enkephalin also inhibits voltage-dependent calcium channels in neuronal cells by binding to them with high affinity. The binding of leu-enkephalin to these channels affects their function and leads to neuronal death. Disulfide bonds are formed between cysteine residues on leu-enkephalin to stabilize this protein's structure.</p>

CAS 60284-47-1

(ala2)-leucine enkephalin

(Ala2)-Leu-Enkephalin

Ref: 3D-FA108404