CAS 60299-11-8

Nifedipine-hydrochloride

Description:

Nifedipine hydrochloride is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It is a dihydropyridine derivative that works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced myocardial oxygen demand. This compound is typically presented as a yellow crystalline powder, which is soluble in organic solvents like ethanol and methanol but has limited solubility in water. Nifedipine hydrochloride is known for its rapid absorption and onset of action, making it effective for acute management of angina. Its pharmacokinetics involve extensive first-pass metabolism, resulting in a variable bioavailability. Common side effects may include headache, flushing, and peripheral edema. As with any medication, it is essential to monitor for potential drug interactions and contraindications, particularly in patients with certain cardiovascular conditions. Overall, nifedipine hydrochloride is a valuable therapeutic agent in cardiovascular medicine, with a well-established profile for efficacy and safety.

Formula: C₁₇H₁₈N₂O₆·ClH

InChI: InChI=1S/C17H18N2O6.ClH/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23;/h5-8,15,18H,1-4H3;1H

InChI key: InChIKey=ISQGFMPRCDAJRT-UHFFFAOYSA-N

SMILES: C(OC)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C2=C(N(=O)=O)C=CC=C2.Cl

Synonyms:

• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester, hydrochloride (1:1)
• Nifedipine-hydrochloride
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester, monohydrochloride

Nifedipine HCl

CAS: 60299-11-8

Nifedipine HCl is a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Formula: C₁₇H₁₉ClN₂O₆

Color and Shape: Solid

Molecular weight: 382.79

Ref: TM-T69021