CAS 603-00-9

Proxyphylline

Description:

Proxyphylline is a chemical compound classified as a xanthine derivative, primarily known for its bronchodilator properties. It is often used in the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD) due to its ability to relax bronchial smooth muscles and improve airflow. The compound has a molecular formula that includes elements such as carbon, hydrogen, nitrogen, and oxygen, contributing to its pharmacological activity. Proxyphylline exhibits a moderate solubility in water and is typically administered in oral form. Its mechanism of action involves the inhibition of phosphodiesterase, leading to increased levels of cyclic AMP, which promotes bronchodilation. Additionally, Proxyphylline may have mild diuretic effects. As with any medication, it is essential to consider potential side effects, which can include gastrointestinal disturbances and cardiovascular effects. Overall, Proxyphylline is a valuable therapeutic agent in managing respiratory diseases, although its use may be limited by the availability of newer medications with improved efficacy and safety profiles.

Formula: C₁₀H₁₄N₄O₃

InChI: InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3

InChI key: InChIKey=KYHQZNGJUGFTGR-UHFFFAOYSA-N

SMILES: C(C(C)O)N1C2=C(N(C)C(=O)N(C)C2=O)N=C1

Synonyms:

• (±)-Proxyphyllin
• 1,3-Dimethyl-7-(2-hydroxypropyl)xanthine
• 1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-
• 2,6-Dioxo-3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethylpurine
• 2-Hydroxypropyl-7-theophylline
• 3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione
• 7-(2-Hydroxypropyl)Theophylline
• 7-(2-hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
• 7-(β-Hydroxypropyl)-1,3-dimethylxanthine
• Brontyl
• Hydroxypropyltheophylline
• Monophylline
• NSC 163343
• Oxypropyltheophylline
• Proxiphylline
• Proxy-Retardoral
• Proxyphylline
• Purophyllin
• Sanwaphyllin
• Sigophyl
• Spantin
• Spasmolysin
• Thean
• Theoden
• Theon
• Theophylline, 7-(2-hydroxypropyl)-

Proxyphylline

CAS: 603-00-9

Formula: C₁₀H₁₄N₄O₃

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 238.25

Ref: 3B-H1430

PROXYPHYLLINE CRS

CAS: 603-00-9

PROXYPHYLLINE CRS

Formula: C₁₀H₁₄N₄O₃

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 238.2432

Ref: 41-P3800000

7-(2-hydroxypropyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

CAS: 603-00-9

Formula: C₁₀H₁₄N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 238.2432

Ref: IN-DA00IAOH

7-(2-Hydroxypropyl)theophylline

CAS: 603-00-9

7-(2-Hydroxypropyl)theophylline

Purity: 99%

Molecular weight: 238.24g/mol

Ref: 54-OR1012044

Proxyphylline

CAS: 603-00-9

Proxyphylline

Purity: ≥98%

Molecular weight: 238.24g/mol

Ref: 54-BUP18231

Proxyphylline

Controlled Product

CAS: 603-00-9

Formula: C₁₀H₁₄N₄O₃

Color and Shape: Neat

Molecular weight: 238.24

Ref: 86-MM1284.00

Proxyphylline

CAS: 603-00-9

Proxyphylline (7-(2-Hydroxypropyl)theophylline) is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor.

Formula: C₁₀H₁₄N₄O₃

Purity: 99.48%

Color and Shape: Solid

Molecular weight: 238.24

Ref: TM-T5940

Proxyphylline

CAS: 603-00-9

Formula: C₁₀H₁₄N₄O₃

Molecular weight: 238.25

Ref: 4Z-T-6044

7-(2-Hydroxypropyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

CAS: 603-00-9

Formula: C₁₀H₁₄N₄O₃

Purity: 95.0%

Molecular weight: 238.247

Ref: 10-F324007

7-(b-Hydroxypropyl)theophylline

Controlled Product

CAS: 603-00-9

Applications A metabolite of Theophylline in human plasma.
References Young, R., et al.: J. Med. Chem., 28, 201 (1993), Abraham, M., et al.: J. Pharm. Sci., 83, 1085 (1994), Caron, G., et al.: J. Med. Chem., 48, 3269 (2005),

Formula: C₁₀H₁₄N₄O₃

Color and Shape: Neat

Molecular weight: 238.24

Ref: TR-H952640

Proxylphylline

Controlled Product

CAS: 603-00-9

Proxylphylline is a methylxanthine drug that is used to treat bronchial asthma. It is an anti-inflammatory agent that acts by inhibiting phosphodiesterases, which are enzymes that break down cyclic nucleotides such as cAMP and cGMP. Proxylphylline has been shown to have inotropic effects on the heart, increasing the force of contraction and decreasing the time between contractions. This drug also reverses the bronchoconstricting effects of allergens. Proxylphylline is absorbed into cells through a chloride channel and then converted to theophylline before it inhibits phosphodiesterases. Theophylline is metabolized in the liver to 3-methylxanthine, 1-methyluric acid, and 1-methylurate.

Purity: Min. 95%

Ref: 3D-FP43739

Diprophylline EP Impurity D

CAS: 603-00-9

Formula: C₁₀H₁₄N₄O₃

Molecular weight: 238.2

Ref: ST-EA-CP-D166004

Proxyphylline

CAS: 603-00-9

Formula: C₁₀H₁₄N₄O₃

Molecular weight: 238.25

Ref: ST-EA-CP-P405000