CAS 603139-12-4

N-(Cyanomethyl)-4-methyl-2-[[2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide

CAS: 603139-12-4

N-(Cyanomethyl)-4-methyl-2-[[2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide is a nonbasic penetrant compound that has been shown to reduce the rate of bone resorption in vivo. It has been shown to inhibit the activity of collagenases and other enzymes involved in bone resorption. The compound can be used as a potential therapeutic for osteoporosis and other diseases that affect bone turnover. This compound was developed through optimization studies with rhesus macaques and cell based assays. The pharmacological treatment with this drug has also been tested on cells from human osteoblasts.

Formula: C₂₃H₂₆F₃N₃O₃S

Purity: Min. 95%

Molecular weight: 481.5 g/mol

Ref: 3D-DZA13912

L-873724

CAS: 603139-12-4

L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.

Formula: C₂₃H₂₆F₃N₃O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 481.53

Ref: TM-T16092