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CAS 6035-45-6

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Leucovorin calcium pentahydrate

Description:
Leucovorin calcium pentahydrate, also known as calcium folinate, is a derivative of folic acid and is primarily used in medical applications, particularly in oncology and to mitigate the side effects of certain chemotherapy agents. It is a white to off-white crystalline powder that is soluble in water, making it suitable for intravenous or intramuscular administration. The substance acts as a form of reduced folate, which can bypass certain metabolic pathways, thereby enhancing the efficacy of drugs like methotrexate while reducing toxicity. Its chemical structure includes a calcium ion, which contributes to its stability and solubility. Leucovorin is often utilized in combination with other medications to treat various types of cancer and to prevent or treat folate deficiency. In addition to its therapeutic uses, it is important to handle this compound with care, following appropriate safety guidelines, as it can interact with other medications and may have contraindications in certain patient populations.
Formula:C20H31CaN7O12
InChI:InChI=1/C20H23N7O7.Ca.5H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;;;;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;5*1H2/q;+2;;;;;/p-2/t12?,13-;;;;;;/m0....../s1
InChI key:NPPBLUASYYNAIG-ZIGBGYJWSA-L
SMILES:C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Ca+2]
Synonyms:
  • Folinic acid, calcium salt pentahydrate
  • Calcium folinate pentahydrate
  • calcium (2S)-2-{[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)carbonyl]amino}pentanedioate pentahydrate
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