CAS 60398-91-6

Bufuralol hydrochloride

Description:

Bufuralol hydrochloride is a pharmaceutical compound primarily recognized for its use as a beta-blocker, which is effective in managing hypertension and certain cardiac conditions. It is a white to off-white crystalline powder that is soluble in water and exhibits a pKa indicative of its basic nature. The compound acts by blocking beta-adrenergic receptors, leading to a decrease in heart rate and myocardial contractility, thus lowering blood pressure. Bufuralol is also notable for its stereochemistry, as it exists in multiple enantiomeric forms, which can influence its pharmacological activity and metabolism. The hydrochloride salt form enhances its stability and solubility, making it suitable for formulation in various dosage forms. Additionally, bufuralol has been studied for its potential effects on peripheral vascular resistance and its role in treating anxiety disorders. As with any medication, it is essential to consider its side effects and contraindications, which may include bradycardia and respiratory issues, particularly in patients with pre-existing conditions.

Formula: C₁₆H₂₃NO₂·ClH

InChI: InChI=1S/C16H23NO2.ClH/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4;/h6-9,13,17-18H,5,10H2,1-4H3;1H

InChI key: InChIKey=KJBONRGCLLBWCJ-UHFFFAOYSA-N

SMILES: C(C)C1=C2C(C=C(C(CNC(C)(C)C)O)O2)=CC=C1.Cl

Synonyms:

• (1)-alpha-(((tert-Butyl)amino)methyl)-7-ethyl-2-benzofuranmethanolhydrochloride
• (±)-Bufuralol hydrochloride
• 2-(Tert-Butylamino)-1-(7-Ethyl-1-Benzofuran-2-Yl)Ethanol Hydrochloride (1:1)
• 2-Benzofuranmethanol, α-[[(1,1-dimethylethyl)amino]methyl]-7-ethyl-, hydrochloride
• 2-Benzofuranmethanol, α-[[(1,1-dimethylethyl)amino]methyl]-7-ethyl-, hydrochloride (1:1)
• Angium
• Ro 3-4787 hydrochloride
• Unii-G66Iy7Q7S4

(±)-Bufuralol hydrochloride

CAS: 60398-91-6

Formula: C₁₆H₂₃NO₂·HCl

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 297.82

Ref: 7W-GL9449

Bufuralol Hydrochloride

Controlled Product

CAS: 60398-91-6

Applications A β-Adrenergic blocker with peripheral vasodilating activity. Antianginal; antihypertensive.
References Francis, R.J., et al.: Eur. J. Clin. Pharmacol., 23, 529 (1982), Pfisterer, M., et al.: J. Cardiovasc. Pharmacol., 6, 417 (1984), Narimatsu, S., et al.: J. Pharmacol. Exp. Ther., 303, 172

Formula: C₁₆H₂₃NO₂·ClH

Color and Shape: Neat

Molecular weight: 297.82

Ref: TR-B689540

(±)-Bufuralol hydrochloride

CAS: 60398-91-6

Bufuralol hydrochloride is a drug that belongs to the class of drugs known as beta-blockers. It is a prodrug and it is metabolized in vivo to 1'-hydroxybufuralol, its active form. Bufuralol hydrochloride has been shown to be an inhibitor of human cytochrome P450 2D6 (CYP2D6) and a substrate for cytochrome P450 1A2 (CYP1A2). The concentrations of bufulalol hydrochloride at which these enzymes are inhibited are different. This means that bufulalol hydrochloride may affect the metabolism of other drugs taken concurrently with it, leading to potential drug interactions. Bufuralol hydrochloride has also been shown to inhibit water vapor from entering cells, which may be due to its ability to bind with protein genes.

Formula: C₁₆H₂₄ClNO₂

Purity: (%) Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 297.82 g/mol

Ref: 3D-FB45106

Bufuralol (hydrochloride)

CAS: 60398-91-6

Bufuralol hydrochloride is a potent, non-selective, orally active β-blocker with partial agonist effects and a CYP2D6 probe.

Formula: C₁₆H₂₄ClNO₂

Color and Shape: Solid

Molecular weight: 297.82

Ref: TM-T21684

(±)-α-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride

CAS: 60398-91-6

Formula: C₁₆H₂₄ClNO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 297.8203

Ref: IN-DA00EF1W