CAS 60628-96-8

Bifonazole

Description:

Bifonazole is an antifungal agent primarily used in the treatment of various fungal infections, particularly those affecting the skin. It belongs to the imidazole class of antifungals and exhibits broad-spectrum activity against dermatophytes, yeasts, and some molds. Bifonazole works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes, thereby disrupting their integrity and leading to cell death. This compound is typically formulated as a topical cream or solution, allowing for localized treatment with minimal systemic absorption. Bifonazole is characterized by its relatively low toxicity and good tolerability, making it suitable for use in various patient populations, including children. Its chemical structure includes a 1-(2,4-dichlorobenzyl)-1H-imidazole moiety, contributing to its antifungal properties. Additionally, it is important to note that while bifonazole is effective against many fungal pathogens, resistance can develop, necessitating careful consideration of its use in clinical settings.

Formula: C₂₂H₁₈N₂

InChI: InChI=1/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H

InChI key: InChIKey=OCAPBUJLXMYKEJ-UHFFFAOYSA-N

SMILES: C(C1=CC=C(C=C1)C2=CC=CC=C2)(N3C=CN=C3)C4=CC=CC=C4

Synonyms:

• (.+-.)-Bifonazole
• 1-(Biphenyl-4-yl-phenyl-methyl)-1H-imidazole
• 1-([1,1′-Biphenyl]-4-ylphenylmethyl)-1H-imidazole
• 1-[Phenyl(4-phenylphenyl)methyl]-1H-imidazole
• 1-[Phenyl-(4-phenylphenyl)methyl]imidazole
• A-One-L
• Agispor
• Amycor
• Azolmen
• BAY-h 4502
• Bedriol
• Bicutrin
• Bifazol
• Bifonazol
• Bifosin
• Mycospor
• Mycosporan
• Trifonazole
• 1-(p,a-Diphenylbenzyl)imidazole
• 1H-Imidazole, 1-([1,1′-biphenyl]-4-ylphenylmethyl)-
• bayh4502
• 1-((4-biphenylyl)phenylmethyl)-1h-imidazole
• BIFONAZOLE(PATENT-NOSUPPLY)
• 1-((1,1’-biphenyl)-4-ylphenylmethyl)-1h-imidazol
• 1[4,ALPHA-DIPHENYLBENZYL]-IMIDAZOLE
• 1-[P,ALPHA-DIPHENYLBENZYL]IMIDAZOLE
• Biphenylylbenzylazole
• 1-(alpha-(4-biphenylyl)benzyl)-imidazol
• 1-[α-(4-biphenyl)benzyl]-1H-imidazole

Bifonazole

CAS: 60628-96-8

Formula: C₂₂H₁₈N₂

Purity: >98.0%(GC)(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 310.40

Ref: 3B-B4173

Bifonazole, 99%

CAS: 60628-96-8

Bifonazole is an imidazole antifungal agent and calmodulin antagonist. It causes a reduction in glycolysis and ATP levels in B16 melanoma cells. Bifonazole is an inhibitor of C14orf1. Bifonazole is an imidazole-based anti-fungal agent with broad spectrum activity against many fungi, molds, yeast and

Formula: C₂₂H₁₈N₂

Purity: 99%

Molecular weight: 310.39

Ref: 02-J63253

Bifonazole

CAS: 60628-96-8

Color and Shape: Neat

Ref: 61-FOR0318.00

BIFONAZOLE FOR SYSTEM SUITABILITY CRS

CAS: 60628-96-8

BIFONAZOLE FOR SYSTEM SUITABILITY CRS

Formula: C₂₂H₁₈N₂

Molecular weight: 310.3917

Ref: 41-Y0001421

BIFONAZOLE CRS

CAS: 60628-96-8

BIFONAZOLE CRS

Formula: C₂₂H₁₈N₂

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 310.3917

Ref: 41-B1110000

1H-Imidazole, 1-([1,1'-biphenyl]-4-ylphenylmethyl)-

CAS: 60628-96-8

Formula: C₂₂H₁₈N₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 310.3917

Ref: IN-DA00IAQ8

Bifonazole

CAS: 60628-96-8

Bifonazole (Bay H-4502) inhibits fungal enzyme cytochrome p450 51, halting ergosterol synthesis, causing cell membrane damage and fungal cell lysis.

Formula: C₂₂H₁₈N₂

Purity: 99.29% - 99.87%

Color and Shape: Solid

Molecular weight: 310.39

Ref: TM-T1187

Bifonazole

CAS: 60628-96-8

Bifonazole

Purity: ≥98%

Molecular weight: 310.39g/mol

Ref: 54-BUP19576

Bifonazole

CAS: 60628-96-8

Bifonazole

Purity: 98%

Molecular weight: 310.39g/mol

Ref: 54-OR1029320

Bifonazole

CAS: 60628-96-8

Formula: C₂₂H₁₈N₂

Color and Shape: White To Off-White Solid

Molecular weight: 310.40

Ref: 4Z-B-621

Bifonazole

Controlled Product

CAS: 60628-96-8

Formula: C₂₂H₁₈N₂

Color and Shape: Neat

Molecular weight: 310.39

Ref: 86-MM0318.00

Bifonazole

CAS: 60628-96-8

Formula: C₂₂H₁₈N₂

Purity: (GC) ≥ 98.0%

Color and Shape: White to almost white powder or crystals

Molecular weight: 310.39

Ref: 7W-GP7347

Bifonazole-d5

CAS: 60628-96-8

Formula: C₂₂H₁₃N₂D₅

Molecular weight: 315.43

Ref: 4Z-B-622

(±)-Bifonazole

CAS: 60628-96-8

Applications (±)-Bifonazole acts as an anti-fungal agent used in the treatment of skin diseases. Causes an increase in Ca2+ concentration and triggers cell death in PC3 human prostate cancer cells.
References Cheng, J. et al.: J. Recep. Sign. Transduct., 34, 493 (2014); Chen, Z. et al.: Mol. Pharm., 12, 590 (2015);

Formula: C₂₂H₁₈N₂

Color and Shape: Neat

Molecular weight: 310.39

Ref: TR-B383400

Bifonazole - Bio-X ™

CAS: 60628-96-8

Bifonazole is an antifungal drug that is used for the treatment of fungal infections. This drug inhibits the production of ergosterol and destabilizes the fungal cytochrome p450 51 enzyme.

Formula: C₂₂H₁₈N₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 310.39 g/mol

Ref: 3D-BP164253

Bifonazole

CAS: 60628-96-8

Anti-fungal; inhibits cytochrome P450 aromatase

Formula: C₂₂H₁₈N₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 310.39 g/mol

Ref: 3D-FP36903

BIFONAZOLE

CAS: 60628-96-8

Purity: 97%

Molecular weight: 310.3999939

Ref: 10-F806741