CAS 60660-75-5: Idarubicinone

Description: Idarubicinone, with the CAS number 60660-75-5, is an anthracycline antibiotic that is primarily used in cancer therapy, particularly for treating various types of leukemia and solid tumors. It is a derivative of doxorubicin and exhibits potent antitumor activity by intercalating into DNA, thereby inhibiting topoisomerase II and disrupting DNA replication and transcription. Idarubicinone is characterized by its red-orange color and is typically administered intravenously. Its mechanism of action involves the generation of free radicals, which contribute to its cytotoxic effects. The compound has a relatively high lipophilicity, allowing for effective cellular uptake. However, like other anthracyclines, it is associated with potential cardiotoxicity, necessitating careful monitoring during treatment. Idarubicinone's pharmacokinetics include a rapid distribution phase followed by a slower elimination phase, and it is metabolized primarily in the liver. Overall, its efficacy in cancer treatment is balanced by the need for vigilance regarding its side effects.

Formula: C₂₀H₁₆O₇

InChI: InChI=1/C20H16O7/c1-8(21)20(27)6-11-13(12(22)7-20)19(26)15-14(18(11)25)16(23)9-4-2-3-5-10(9)17(15)24/h2-5,12,22,25-27H,6-7H2,1H3/t12-,20-/m0/s1

Synonyms:

• (7S,9S)9-Acetyl-7,8,9,10-tetrahydro-6,7,9,11-tetrahydroxy-5,12-naphtacenedione
• 4-Demethoxydaunomycinone
• Idarubicin aglycone
• 5,12-Naphthacenedione, 9-acetyl-7,8,9,10-tetrahydro-6,7,9,11-tetrahydroxy-, (7S,9S)-
• 5,12-Naphthacenedione, 9-acetyl-7,8,9,10-tetrahydro-6,7,9,11-tetrahydroxy-, (7S-cis)-
• (7S,9S)-9-acetyl-6,7,9,11-tetrahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione

(7S,9S)9-ACETYL-7,8,9,10-TETRAHYDRO-6,7,9,11-TETRAHYDROXY-5,12-NAPHTACENEDIONE

CAS: 60660-75-5

• Formula: C₂₀H₁₆O₇
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 368.33684

Idarubicinone

CAS: 60660-75-5

• Formula: C₂₀H₁₆O₇
• Color and Shape: Red Solid
• Molecular weight: 368.34

(7S,9S)-9-Acetyl-6,7,9,11-tetrahydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione

CAS: 60660-75-5

• Formula: C₂₀H₁₆O₇
• Color and Shape: Neat
• Molecular weight: 368.34

(7S,9S)-9-Acetyl-6,7,9,11-tetrahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione

CAS: 60660-75-5

• Purity: 97.0%
• Molecular weight: 368.34100341796875

(7S,9S)-9-Acetyl-6,7,9,11-tetrahydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione

CAS: 60660-75-5

Acetylated analogues of homophthalic acid are a class of chemical compounds that have been studied …

• Formula: C₂₀H₁₆O₇
• Purity: Min. 95%
• Molecular weight: 368.34 g/mol