CAS 60719-84-8

Amrinone

Description:

Amrinone, with the CAS number 60719-84-8, is a pharmaceutical compound primarily used as a cardiotonic agent. It belongs to the class of phosphodiesterase inhibitors, specifically targeting phosphodiesterase type III. This mechanism enhances myocardial contractility and promotes vasodilation, making it beneficial in the treatment of heart failure and certain types of shock. Amrinone is characterized by its ability to increase intracellular cyclic AMP levels, which leads to improved cardiac output without significantly increasing heart rate. The compound is typically administered intravenously and is known for its relatively short half-life, necessitating careful monitoring of dosage and patient response. Common side effects may include hypotension, arrhythmias, and gastrointestinal disturbances. Due to its pharmacological profile, amrinone is often used in acute settings, particularly in patients who do not respond adequately to conventional therapies. However, its use has declined with the advent of newer agents that offer improved safety and efficacy profiles.

Formula: C₁₀H₉N₃O

InChI: InChI=1/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)

InChI key: InChIKey=RNLQIBCLLYYYFJ-UHFFFAOYSA-N

SMILES: NC1=CC(=CNC1=O)C=2C=CN=CC2

Synonyms:

• (3,4'-Bipyridin)-6(1H)-one, 5-amino-
• 3-Amino-5-(4-pyridinyl)-1,2-dihydro-2-pyridone
• 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone
• 3-Amino-5-(pyridin-4-yl)-1,2-dihydropyridin-2-one
• 3-Amino-5-(pyridin-4-yl)pyridin-2(1H)-one
• 3-Amino-5-pyridin-4-yl-1H-pyridin-2-one
• 5-Amino(3,4'-bipyridin)-6(1H)-one
• 5-Amino-1,6-dihydro-6-oxo-[3,4'-bipyridine]
• Amrinon
• Amrinona
• Amrinona [INN-Spanish]
• Amrinonum
• Amrinonum [INN-Latin]
• Awd 08-250
• Brn 0744819
• Cartonic
• Ccris 3794
• Cordemcura
• Inamrinone
• Inamrinone [USAN:INN:BAN]
• Inocor
• Unii-Jut23379Tn
• Vesistol
• Win 40680
• Win40680
• Wincavam
• Wincoram
• Amrinone
• 5-25-15-00181 (Beilstein Handbook Reference)
• awd08-250
• 4’-bipyridin)-6(1h)-one,5-amino-(
• 5-AMINO-(3,4''-BIPYRIDIN)-6(1H)-ONE (AMRINONE)
• Amirinone

Inamrinone

CAS: 60719-84-8

Lactams not elsewhere specified or included

Formula: C₁₀H₉N₃O

Color and Shape: Pale Yellow Tan Powder

Molecular weight: 187.07456

Ref: 45-1034308

[3,4'-Bipyridin]-6(1H)-one, 5-amino-

CAS: 60719-84-8

Formula: C₁₀H₉N₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 187.1980

Ref: IN-DA00IAQK

Amrinone

CAS: 60719-84-8

Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.

Formula: C₁₀H₉N₃O

Purity: 98.88% - 99.45%

Color and Shape: Solid

Molecular weight: 187.2

Ref: TM-T1265

5-Amino-[3,4'-Bipyridin]-6(1H)-One

CAS: 60719-84-8

5-Amino-[3,4'-Bipyridin]-6(1H)-One

Purity: 99%

Molecular weight: 187.2g/mol

Ref: 54-OR1027182

Amrinone

CAS: 60719-84-8

Amrinone

Purity: ≥98%

Molecular weight: 187.2g/mol

Ref: 54-BUP15940

Amrinone, USP grade

CAS: 60719-84-8

Formula: C₁₀H₉N₃O

Molecular weight: 187.20

Ref: 7W-GP2820

Amrinone

CAS: 60719-84-8

Formula: C₁₀H₉N₃O

Purity: 98.0 - 102.0 % (anhydrous basis)

Color and Shape: Pale yellow or yellow-tan crystalline powder

Molecular weight: 187.20

Ref: 7W-GP7331

Amrinone

CAS: 60719-84-8

Formula: C₁₀H₉N₃O

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Amber powder to crystal

Molecular weight: 187.20

Ref: 3B-A3625

Amrinone

CAS: 60719-84-8

Applications A selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. Cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Benotti, J.R., et al.: N. Engl. J. Med., 21, 1373 (1978), Ward, A., et al.: Drugs, 26, 468 (1983), Bottorff, M.B., et al.: Pharmacotherapy, 5, 227 (1985),

Formula: C₁₀H₉N₃O

Color and Shape: Neat

Molecular weight: 187.20

Ref: TR-A635000

5-Amino-(3,4'-bipyridin)-6(1H)-one

CAS: 60719-84-8

Phosphodiesterase type 3 inhibitor; positive inotropic agent; vasodilatory

Formula: C₁₀H₉N₃O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 187.2 g/mol

Ref: 3D-FA17893

Amrinone - Bio-X ™

CAS: 60719-84-8

Amrinone is a phosphodiesterase type 3 inhibitor that is used in the treatment of congestive heart failure. It is considered a vasodilator that increases stroke volume and cardiac output by stimulating myocardial contractility. Amrinone results in increased cAMP and cGMP which leads to an increase in calcium influx thus creating a positive inotropic effect.

Formula: C₁₀H₉N₃O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 187.2 g/mol

Ref: 3D-BA166404

5-Amino-[3,4′-bipyridin]-6(1H)-one

CAS: 60719-84-8

Formula: C₁₀H₉N₃O

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 187.202

Ref: 10-F220489