CAS 60719-84-8: Amrinone

Description: Amrinone, with the CAS number 60719-84-8, is a pharmaceutical compound primarily used as a cardiotonic agent. It belongs to the class of phosphodiesterase inhibitors, specifically targeting phosphodiesterase type III. This mechanism enhances myocardial contractility and promotes vasodilation, making it beneficial in the treatment of heart failure and certain types of shock. Amrinone is characterized by its ability to increase intracellular cyclic AMP levels, which leads to improved cardiac output without significantly increasing heart rate. The compound is typically administered intravenously and is known for its relatively short half-life, necessitating careful monitoring of dosage and patient response. Common side effects may include hypotension, arrhythmias, and gastrointestinal disturbances. Due to its pharmacological profile, amrinone is often used in acute settings, particularly in patients who do not respond adequately to conventional therapies. However, its use has declined with the advent of newer agents that offer improved safety and efficacy profiles.

Formula: C₁₀H₉N₃O

InChI: InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)

InChI key: InChIKey=RNLQIBCLLYYYFJ-UHFFFAOYSA-N

SMILES: O=C1NC=C(C=C1N)C=2C=CN=CC2

Synonyms:

• (3,4'-Bipyridin)-6(1H)-one, 5-amino-
• 3-Amino-5-(4-pyridinyl)-1,2-dihydro-2-pyridone
• 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone
• 3-Amino-5-(pyridin-4-yl)-1,2-dihydropyridin-2-one
• 3-Amino-5-(pyridin-4-yl)pyridin-2(1H)-one
• 3-Amino-5-pyridin-4-yl-1H-pyridin-2-one
• 5-Amino(3,4'-bipyridin)-6(1H)-one
• 5-Amino-1,6-dihydro-6-oxo-[3,4'-bipyridine]
• Amrinon
• Amrinona
• Amrinona [INN-Spanish]
• Amrinonum
• Amrinonum [INN-Latin]
• Awd 08-250
• Brn 0744819
• Cartonic
• Ccris 3794
• Cordemcura
• Inamrinone
• Inamrinone [USAN:INN:BAN]
• Inocor
• Unii-Jut23379Tn
• Vesistol
• Win 40680
• Win40680
• Wincavam
• Wincoram
• Amrinone
• 5-25-15-00181 (Beilstein Handbook Reference)

Inamrinone

CAS: 60719-84-8

Lactams not elsewhere specified or included

• Formula: C₁₀H₉N₃O
• Color and Shape: Pale Yellow Tan Powder
• Molecular weight: 187.07456

[3,4'-Bipyridin]-6(1H)-one, 5-amino-

CAS: 60719-84-8

• Formula: C₁₀H₉N₃O
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 187.198

Amrinone

CAS: 60719-84-8

Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory …

• Formula: C₁₀H₉N₃O
• Purity: 98.88% - 99.45%
• Color and Shape: Solid
• Molecular weight: 187.2

5-Amino-[3,4Õ-Bipyridin]-6(1H)-One

CAS: 60719-84-8

• Purity: 98%
• Molecular weight: 187.2g/mol

Amrinone

CAS: 60719-84-8

• Purity: 99.86%
• Molecular weight: 187.2g/mol

Amrinone, USP grade

CAS: 60719-84-8

• Formula: C₁₀H₉N₃O
• Molecular weight: 187.20

Amrinone

CAS: 60719-84-8

• Formula: C₁₀H₉N₃O
• Purity: 98.0 - 102.0 % (anhydrous basis)
• Color and Shape: Pale yellow or yellow-tan crystalline powder
• Molecular weight: 187.20

Amrinone

CAS: 60719-84-8

• Formula: C₁₀H₉N₃O
• Purity: >95.0%(T)(HPLC)
• Color and Shape: White to Amber powder to crystal
• Molecular weight: 187.20

Amrinone

CAS: 60719-84-8

Applications A selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. Cardiotonic. Not …

• Formula: C₁₀H₉N₃O
• Color and Shape: Neat
• Molecular weight: 187.20

5-Amino-[3,4'-bipyridin]-6(1H)-one

CAS: 60719-84-8

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 187.20199584960938

5-Amino-(3,4'-bipyridin)-6(1H)-one

CAS: 60719-84-8

Phosphodiesterase type 3 inhibitor; positive inotropic agent; vasodilatory

• Formula: C₁₀H₉N₃O
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 187.2 g/mol

Amrinone - Bio-X ™

CAS: 60719-84-8

Amrinone is a phosphodiesterase type 3 inhibitor that is used in the treatment of congestive …

• Formula: C₁₀H₉N₃O
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 187.2 g/mol