CAS 60755-80-8

Sanguinine

Description:

Sanguinine, with the CAS number 60755-80-8, is a chemical compound that belongs to the class of alkaloids, which are naturally occurring organic compounds that mostly contain basic nitrogen atoms. It is derived from the plant Sanguinaria canadensis, commonly known as bloodroot. Sanguinine is characterized by its complex structure, which includes multiple rings and functional groups that contribute to its biological activity. This compound has been studied for its potential pharmacological properties, including antimicrobial and anti-inflammatory effects. Additionally, it exhibits a range of biological activities that may be relevant in medicinal chemistry. However, due to its alkaloidal nature, it may also present toxicity concerns, necessitating careful handling and further research to fully understand its safety profile and therapeutic potential. As with many natural products, the extraction and purification processes can significantly influence its characteristics and efficacy in various applications.

Formula: C₁₆H₁₉NO₃

InChI: InChI=1/C16H19NO3/c1-17-7-6-16-5-4-11(18)8-13(16)20-15-12(19)3-2-10(9-17)14(15)16/h2-5,11,13,18-19H,6-9H2,1H3/t11-,13-,16-/m0/s1

InChI key: InChIKey=OYSGWKOGUVOGFQ-RBOXIYTFSA-N

SMILES: OC1=C2C=3[C@]4([C@@](O2)(C[C@@H](O)C=C4)[H])CCN(C)CC3C=C1

Synonyms:

• (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol
• 6H-Benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol, 4a,5,9,10,11,12-hexahydro-11-methyl-, [4aS-(4aα,6β,8aR*)]-
• 6H-benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol, 4a,5,9,10,11,12-hexahydro-11-methyl-, (4aS,6R,8aS)-
• Galanthamine, O-demethyl-
• O-Demethylgalanthamine
• Sanguinine
• O-DESMETHYLGALANTHAMINE
• 10-Methyl-galantham-1-ene-3,6-diol
• O-Demethyl-galanthamine
• 10-Methyl-galantham-1-ene-3b,6-diol
• (4aS,8aS)-11-Methyl-4aα,5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzoazepine-3,6β-diol
• (8aS)-5,6,9,10,11,12-Hexahydro-11-methyl-4aαH-benzofuro[3a,3,2-ef][2]benzazepine-3,6β-diol

O-Desmethyl Galanthamine

CAS: 60755-80-8

O-Desmethyl Galanthamine

Purity: ≥95%

Molecular weight: 273.33g/mol

Ref: 54-BUP02976

O-Desmethyl Galantamine

CAS: 60755-80-8

Formula: C₁₆H₁₉NO₃

Color and Shape: White To Off-White Solid

Molecular weight: 273.33

Ref: 4Z-G-017

O-Desmethyl Galanthamine

CAS: 60755-80-8

O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid and it is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.

Formula: C₁₆H₁₉NO₃

Purity: 99.62%

Color and Shape: Pale Yellow Powder

Molecular weight: 273.33

Ref: TM-TN6786

O-Desmethyl Galanthamine

Controlled Product

CAS: 60755-80-8

Applications A metabolite of Galanthamine (G188500), a selective acetylcholinesterase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mannens, G., et al.: Drug Metab. Dispos., 30, 553 (2002), Farlow, M., et al.: Clin. Pharmacokinet., 42, 1383 (2003), Cisar, P., et al.: J. Pharm. Biomed. Anal., 37, 1059 (2005), Geerts, H., et al.: Brain Res., 1033, 186 (2005),

Formula: C₁₆H₁₉NO₃

Color and Shape: Neat

Molecular weight: 273.33

Ref: TR-D292030

O-Desmethyl galanthamine

Controlled Product

CAS: 60755-80-8

O-Desmethyl galanthamine is a biochemical compound, which is a derivative of the alkaloid galanthamine. This product is typically sourced from the Amaryllidaceae family of plants, known for their natural production of bioactive alkaloids. The mode of action of O-Desmethyl galanthamine involves competitive inhibition of acetylcholinesterase, an enzyme responsible for the breakdown of the neurotransmitter acetylcholine. By inhibiting this enzyme, O-Desmethyl galanthamine increases acetylcholine levels in synaptic clefts, enhancing cholinergic transmission.

Formula: C₁₆H₁₉NO₃

Purity: Min. 95%

Color and Shape: Off-White To Yellow Solid

Molecular weight: 273.33 g/mol

Ref: 3D-FD21272

O-Desmethyl Galanthamine

CAS: 60755-80-8

Purity: 98%

Molecular weight: 273.332

Ref: 10-F987306

O-Desmethyl Galantamine

CAS: 60755-80-8

Formula: C₁₆H₁₉NO₃

Molecular weight: 273.33

Ref: ST-EA-CP-G10009