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CAS 60768-15-2

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D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6,7-pentadeoxy-α-D-ribo-heptopyranosyl-(1→4)]- (9CI)

Description:
D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6,7-pentadeoxy-α-D-ribo-heptopyranosyl-(1→4)]- (9CI), with the CAS number 60768-15-2, is a complex glycosylated aminoglycoside antibiotic. This compound features a unique structure characterized by multiple sugar moieties, including an arabinopyranosyl and a heptopyranosyl unit, which contribute to its biological activity. The presence of amino groups enhances its interaction with bacterial ribosomes, inhibiting protein synthesis and thus exhibiting antimicrobial properties. D-Streptamine is particularly effective against certain Gram-negative bacteria, making it valuable in clinical settings. Its solubility in water and stability under physiological conditions are important for its therapeutic applications. Additionally, the compound's stereochemistry and functional groups play a crucial role in its mechanism of action and pharmacokinetics. As with many aminoglycosides, potential side effects may include nephrotoxicity and ototoxicity, necessitating careful monitoring during use. Overall, D-Streptamine represents a significant class of antibiotics with specific structural features that dictate its efficacy and safety profile.
Formula:C20H41N5O8
InChI:InChI=1/C20H41N5O8/c1-7(21)9-5-4-8(22)18(31-9)32-15-10(23)12(26)11(24)16(13(15)27)33-19-14(28)17(25-3)20(2,29)6-30-19/h7-19,25-29H,4-6,21-24H2,1-3H3
Synonyms:
  • 2-Hydroxygentamicin C2
  • D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6,7-pentadeoxy-α-D-ribo-heptopyranosyl-(1→4)]- (9CI)
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