CAS 60784-46-5

N-(2-Chloroethyl)-N′-(2-hydroxyethyl)-N-nitrosourea

Description:

N-(2-Chloroethyl)-N′-(2-hydroxyethyl)-N-nitrosourea, commonly known as chloroethyl nitrosourea (CENU), is a synthetic organic compound that belongs to the class of nitrosoureas, which are known for their alkylating properties. This compound is characterized by its ability to form covalent bonds with DNA, leading to the disruption of cellular replication and function, making it of interest in cancer chemotherapy. It typically appears as a white to off-white solid and is soluble in organic solvents. CENU is particularly noted for its selective cytotoxicity against certain types of cancer cells, including gliomas and other tumors. However, it is also associated with significant side effects, including myelosuppression and potential neurotoxicity. Due to its reactivity, it must be handled with care, following appropriate safety protocols to mitigate risks associated with exposure. Its use in clinical settings is often limited to specific cases where other treatments have failed or are not viable.

Formula: C₅H₁₀ClN₃O₃

InChI: InChI=1S/C5H10ClN3O3/c6-1-3-9(8-12)5(11)7-2-4-10/h10H,1-4H2,(H,7,11)

InChI key: InChIKey=YJZJEQBSODVMTH-UHFFFAOYSA-N

SMILES: N(C(NCCO)=O)(CCCl)N=O

Synonyms:

• 1-(2-Chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea
• 1-(2-Hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea
• 1-Nitroso-1-(2-chloroethyl)-3-(2-hydroxyethyl)urea
• 1-Nitroso-1-chloroethyl-3-hydroxyethylurea
• Brn 1956525
• CNU-ethanol
• Ccris 3034
• Elmustina
• Elmustina [Spanish]
• Elmustine
• Elmustine [INN]
• Elmustinum
• Elmustinum [Latin]
• Hecnu
• Hemustine
• Hydroxyethyl CNU
• N-(2-Chloroethyl)-N'-(2-hydroxyethyl)-N-nitrosourea
• N-Hydroxyethyl-N-chloroethyl-nitrosourea
• Nsc-294895
• Unii-Nat2Fd82D7
• Urea, 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitroso-

Elmustine

CAS: 60784-46-5

Formula: C₅H₁₀ClN₃O₃

Molecular weight: 195.60

Ref: 4Z-E-133001

Hemustine

Controlled Product

CAS: 60784-46-5

Formula: C₅H₁₀ClN₃O₃

Color and Shape: Off-White

Molecular weight: 195.6

Ref: TR-H245668

Hemustine-d4

Controlled Product

CAS: 60784-46-5

Formula: C₅D₄H₆ClN₃O₃

Color and Shape: Neat

Molecular weight: 199.629

Ref: TR-H245673

Hemustine

CAS: 60784-46-5

Hemustine is a chemotherapy agent, which is a synthetic compound derived from the class of nitrosoureas. It functions as an alkylating agent with the primary mode of action involving the formation of cross-links with DNA. This cross-linking inhibits DNA replication and transcription, ultimately leading to cell apoptosis, particularly in rapidly dividing cells. Hemustine is utilized predominantly in the treatment of various neoplastic diseases, including brain tumors and lymphomas. Due to its ability to penetrate the blood-brain barrier, it is especially useful in managing malignancies of the central nervous system. Its application underscores the need for precision in dosage and administration to mitigate potential cytotoxic effects on non-cancerous cells. Hemustine's role in oncology represents a critical component of multi-modal treatment strategies, often combined with other therapeutic agents to optimize efficacy and patient outcomes.

Formula: C₅H₁₀ClN₃O₃

Purity: Min. 95%

Molecular weight: 195.60 g/mol

Ref: 3D-KCA78446

Hemustine

CAS: 60784-46-5

Hemustine is an inhibitor of human glutathione reductase and widely used as an anti-tumor agent.

Formula: C₅H₁₀ClN₃O₃

Color and Shape: Solid

Molecular weight: 195.6

Ref: TM-T69010