CAS 608137-33-3

Lisdexamfetamine dimesylate

Description:

Lisdexamfetamine dimesylate is a prodrug of dextroamphetamine, primarily used in the treatment of attention deficit hyperactivity disorder (ADHD) and binge eating disorder. It is characterized by its unique mechanism of action, where it is metabolized in the body to release dextroamphetamine, which acts as a central nervous system stimulant. The substance is a white to off-white crystalline powder that is soluble in water, facilitating its absorption when administered orally. Lisdexamfetamine dimesylate has a relatively long duration of action, which allows for once-daily dosing, making it convenient for patients. Its pharmacokinetics are influenced by factors such as individual metabolism and the presence of food in the gastrointestinal tract. The compound is classified as a Schedule II controlled substance due to its potential for abuse and dependence. Common side effects may include decreased appetite, insomnia, and increased heart rate. Overall, lisdexamfetamine dimesylate represents an important therapeutic option for managing ADHD and related conditions.

Formula: C₁₅H₂₅N₃O·2CH₄O₃S

InChI: InChI=1S/C15H25N3O.CH4O3S/c1-12(11-13-7-3-2-4-8-13)18-15(19)14(17)9-5-6-10-16;1-5(2,3)4/h2-4,7-8,12,14H,5-6,9-11,16-17H2,1H3,(H,18,19);1H3,(H,2,3,4)/t12-,14-;/m0./s1

InChI key: InChIKey=KZHOHVKYLXWNQP-KYSPHBLOSA-N

SMILES: C([C@@H](NC([C@H](CCCCN)N)=O)C)C1=CC=CC=C1.S(C)(=O)(=O)O

Synonyms:

• Hexanamide, 2,6-diamino-N-[(1S)-1-methyl-2-phenylethyl]-, (2S)-, dimethanesulfonate
• Hexanamide, 2,6-diamino-N-[(1S)-1-methyl-2-phenylethyl]-, (2S)-, methanesulfonate (1:2)
• LDX
• Lis-dexamfetamine dimesylate
• Lisdexamfetamine mesilate
• Lisdexamfetamine mesylate
• Lisdexamphetamine dimesylate
• N-(<span class="text-smallcaps">L</smallcap>-Lysyl)-<smallcap>D</span>-amphetamine dimesylate
• Nrp 104
• Spd 489
• Spd489
• Unii-Sjt761Gegs
• Vyvanse

Lisdexamphetamine Dimesylate

Controlled Product

CAS: 608137-33-3

Applications Lisdexamphetamine Dimesylate is used as a treatment for adults with attention-deficit/hyperactivity disorder (ADHD). Lisdexamphetamine Dimesylate has been shown to improve executive dysfunction and depressive symptoms in people with mild major depressive disorder (MDD).
References Martin, P.T., et al.: Clin. Drug Invest., 34, 147 (2014); Madhoo, M., et. al.: Neuropsychopharmacol., 39, 1388 (2014);

Formula: C₁₅H₂₅N₃O·2CH₄O₃S

Color and Shape: Neat

Molecular weight: 455.59

Ref: TR-L468885

Lisdexamphetamine-d3 Dimesylate (1mg/ml (as free base) in Methanol)

Controlled Product

CAS: 608137-32-2, 608137-33-3

Formula: C₁₅H₂₂D₃N₃O·CH₄O₃S

Color and Shape: Single Solution

Molecular weight: 362.5

Ref: TR-KIT1810

Lisdexamphetamine Dimesylate (1mg/ml in Methanol)

Controlled Product

CAS: 608137-33-3

Formula: C₁₅H₂₅N₃O·2CH₄O₃S

Color and Shape: Single Solution

Molecular weight: 455.59

Ref: TR-KIT2550