CAS 608141-44-2

Apremilast enantiomer

Description:

Apremilast enantiomer, identified by the CAS number 608141-44-2, is a chiral compound that serves as a selective inhibitor of phosphodiesterase 4 (PDE4). This characteristic makes it significant in the treatment of inflammatory conditions, particularly psoriasis and psoriatic arthritis. The enantiomer exhibits a specific three-dimensional arrangement of atoms, which influences its biological activity and pharmacokinetics. Typically, enantiomers can have different effects in biological systems, and in the case of Apremilast, the specific enantiomer is designed to maximize therapeutic efficacy while minimizing side effects. The compound is usually administered orally and is known for its favorable safety profile compared to other systemic treatments. Its mechanism of action involves increasing intracellular levels of cyclic AMP, leading to the modulation of inflammatory responses. As with many pharmaceuticals, the stability, solubility, and bioavailability of the enantiomer are critical factors that influence its effectiveness in clinical applications.

Synonyms:

• (R)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

Apremilast R-Enantiomer

CAS: 608141-44-2

Other aromatic organo-sulfur compounds (excluding pesticides)

Formula: C₂₂H₂₄N₂O₇S

Color and Shape: White Off-White Powder

Molecular weight: 460.13042

Ref: 45-1041851

(R)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

CAS: 608141-44-2

Formula: C₂₂H₂₄N₂O₇S

Purity: 97%

Color and Shape: Solid

Molecular weight: 460.5002

Ref: IN-DA00F91V

(R)-Apremilast

CAS: 608141-44-2

(R)-Apremilast ((R)-CC-10004) is the enantiomer of Apremilast and one of the isoindoline derivatives.

Formula: C₂₂H₂₄N₂O₇S

Purity: 99.59%

Color and Shape: Solid

Molecular weight: 460.5

Ref: TM-T12612

(R)-Apremilast

CAS: 608141-44-2

Formula: C₂₂H₂₄N₂O₇S

Color and Shape: White To Off-White Solid

Molecular weight: 460.50

Ref: 4Z-A-182011

(R)-Apremilast

CAS: 608141-44-2

(R)-Apremilast

Purity: ≥98%

Molecular weight: 460.5g/mol

Ref: 54-BUP09126

(R)-Apremilast

CAS: 608141-44-2

Color and Shape: Solid

Molecular weight: 460.5

Ref: 10-F986735

Apremilast R-Isomer

CAS: 608141-44-2

Formula: C₂₂H₂₄N₂O₇S

Molecular weight: 460.50

Ref: ST-EA-CP-A77010

(R)-Apremilast

Controlled Product

CAS: 608141-44-2

Applications (R)-Apremilast is an enantiomer of Apremilast (A729700), an oral phosphodiesterase 4 inhibitor is used in the treatment of psoriatic arthritis.
References Gan, E. et al.: BioDrugs, 27, 359 (2013); Pathan, E. et al.: Annal. Rheum. DIs., 72, 1475 (2013);

Formula: C₂₂H₂₄N₂O₇S

Color and Shape: Neat

Molecular weight: 460.5

Ref: TR-A729705

(R)-Apremilast-d5

Controlled Product

CAS: 608141-44-2

Formula: C₂₂D₅H₁₉N₂O₇S

Color and Shape: Neat

Molecular weight: 465.531

Ref: TR-A729707

(R)-Apremilast

CAS: 608141-44-2

(R)-Apremilast-d5 is a metabolite of apremilast, which is a small molecule drug that inhibits phosphodiesterase (PDE) enzymes. It has been shown to suppress inflammation in vitro and in vivo. Metabolism studies have shown that the main metabolites of apremilast are the acid form and the glucuronide form. Apremilast-d5 is a synthetic impurity generated by oxidation of an intermediate during synthesis. It can also be found as a natural metabolite in plants such as licorice or black pepper. This product is used for HPLC standards for apremilast and its metabolites.

Formula: C₂₂H₂₄N₂O₇S

Purity: Min. 95%

Molecular weight: 460.5 g/mol

Ref: 3D-IZA14144