CAS 608512-97-6

6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one

Description:

6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one is a complex organic compound characterized by its unique bicyclic structure, which incorporates both a pyrrolo and benzothiazole moiety. This compound features a dihydro-pyrrolo framework, indicating the presence of a saturated ring system, and an imidazole group that contributes to its potential biological activity. The presence of the imidazolylmethylene substituent suggests that it may engage in various interactions, such as hydrogen bonding or coordination with metal ions, which can enhance its reactivity and solubility in different solvents. The compound's structure may confer specific pharmacological properties, making it of interest in medicinal chemistry for potential therapeutic applications. Additionally, its molecular weight and specific functional groups can influence its stability, solubility, and interaction with biological targets. Overall, this compound exemplifies the intricate relationship between molecular structure and biological activity, warranting further investigation for its potential uses in drug development or other chemical applications.

Formula: C₁₃H₈N₄OS

InChI: InChI=1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)

InChI key: InChIKey=VFBGXTUGODTSPK-UHFFFAOYSA-N

SMILES: C(=C1C=2C3=C(C=CC2NC1=O)N=CS3)C4=CN=CN4

Synonyms:

• GW 506033X
• 7H-Pyrrolo[2,3-g]benzothiazol-7-one, 6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-
• 7H-Pyrrolo[2,3-g]benzothiazol-7-one, 6,8-dihydro-8-(1H-imidazol-4-ylmethylene)-
• 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one

8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE

CAS: 608512-97-6

Formula: C₁₃H₈N₄OS

Purity: %

Color and Shape: Solid

Molecular weight: 268.2938

Ref: IN-DA00EBSF

PKR-IN-C16

CAS: 608512-97-6

PKR-IN-C16

Purity: ≥95%

Molecular weight: 268.29g/mol

Ref: 54-BUP05067

PKR-IN-C16

CAS: 608512-97-6

PKR-IN-C16: inhibits PKR autophosphorylation and translation blockade; binds ATP site; IC50 of 186-210 nM; protects cells from ER stress damage.

Formula: C₁₃H₈N₄OS

Purity: 97.8%

Color and Shape: Solid

Molecular weight: 268.29

Ref: TM-T16550

Imidazolo-oxindole PKR inhibitor C16(PKR Inhibitor)

Controlled Product

CAS: 608512-97-6

Applications PKR Inhibitor is a drug which acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function in vivo and has neuroprotective and nootropic effects in animal studies.
References Jammi, N., et al.: Biochem. Biophys. Res. Commun., 308, 50 (2003); Ingrand, S., et al.: Neurosci. Lett., 409, 192 (2006); Chen, H., et al.: Eur. J. Neurosci., 28, 2003 (2008); Couturier, J., et al.: J. Biol. Chem., 285, 1272 (2010)

Formula: C₁₃H₈N₄OS

Color and Shape: Neat

Molecular weight: 268.29

Ref: TR-P572500