CAS 60857-08-1

Prostratin

Description:

Prostratin is a natural compound classified as a phorbol ester, derived from the bark of the Pacific bay tree, *Dacryodes excelsa*. It is known for its potential therapeutic properties, particularly in the context of HIV research, as it has been shown to activate latent HIV reservoirs, making it a subject of interest in efforts to develop strategies for eradicating the virus from the body. Prostratin exhibits a complex molecular structure characterized by a tetracyclic ring system, which contributes to its biological activity. The compound has been studied for its role in modulating various cellular pathways, including those involved in inflammation and immune response. Additionally, Prostratin has demonstrated potential anticancer properties, although further research is needed to fully understand its mechanisms and efficacy. Its CAS number, 60857-08-1, is used for identification in chemical databases and regulatory contexts. Overall, Prostratin represents a promising area of study in medicinal chemistry and pharmacology, particularly in the fields of virology and oncology.

Formula: C₂₂H₃₀O₆

InChI: InChI=1S/C22H30O6/c1-11-6-16-20(26,18(11)25)9-14(10-23)7-15-17-19(4,5)21(17,28-13(3)24)8-12(2)22(15,16)27/h6-7,12,15-17,23,26-27H,8-10H2,1-5H3/t12-,15+,16-,17-,20-,21+,22-/m1/s1

InChI key: InChIKey=BOJKFRKNLSCGHY-HXGSDTCMSA-N

SMILES: O(C(C)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)C2)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]

Synonyms:

• (1aR,1bS,4aR,7aS,7bR,8R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetate
• (1bS,4aR)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetate
• (1bS,4aR,7aS,7bR,8R)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetate
• 12-Deoxyphorbol 13-acetate
• 13-O-Acetyl-12-deoxyphorbol
• 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR,1bS,4aR,7aS,7bR,8R,9aS)-
• 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, [1aR-(1aα,1bβ,4aβ,7aα,7bα,8α,9aα)]-
• K 101A
• NSC 623310
• Prostratin
• Sa 101A
• Stillingia factor S₇
• Stillingia factor S7

5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one,9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-,(1aR,1bS,4aR,7aS,7bR,8R,9aS)-

CAS: 60857-08-1

Formula: C₂₂H₃₀O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 390.4700

Ref: IN-DA01DP3S

Prostratin

CAS: 60857-08-1

Prostratin is an orally active PKC activator,an NF-κB activator and activates HIV expression. Induces KRAS phosphorylation and inhibits tumor growth.

Formula: C₂₂H₃₀O₆

Purity: 98%

Color and Shape: White To Off-White Powder

Molecular weight: 390.47

Ref: TM-T21441

Prostratin

CAS: 60857-08-1

Formula: C₂₂H₃₀O₆

Purity: 95%~99%

Molecular weight: 390.476

Ref: BP-BP1674

Prostratin

CAS: 60857-08-1

Prostratin

Purity: >99%

Molecular weight: 390.47g/mol

Ref: 54-BIP1032

Prostratin

Controlled Product

CAS: 60857-08-1

Applications It is a protein kinase C activator found in the bark of the mamala tree of Samoa, Homalanthus nutans (Euphorbiaceae). Research indicated that prostratin has potential to be useful in the treatment of HIV as it flushes viral reservoirs in latently infected CD4+ T-cells.
References Reuben, et al.: Clin. Cancer Res., 6, 1671 (2000), Korin, Y., et al.: J. Virol., 76, 8118 (2002), Wei, X., et al.: Nature, 422, 307 (2003), Kutsch, O., et al.: Antimicrob. Agents Chemother., 48, 1652 (2004),

Formula: C₂₂H₃₀O₆

Color and Shape: Neat

Molecular weight: 390.47

Ref: TR-P838800