CAS 609-15-4

Ethyl 2-chloroacetoacetate

Description:

Ethyl 2-chloroacetoacetate, with the CAS number 609-15-4, is an organic compound that belongs to the class of acetoacetates. It is characterized by the presence of both an ethyl ester and a chloro substituent on the acetoacetate moiety. This compound typically appears as a colorless to pale yellow liquid with a fruity odor. It is soluble in organic solvents such as ethanol and ether but has limited solubility in water due to its hydrophobic ethyl group. Ethyl 2-chloroacetoacetate is known for its reactivity, particularly in nucleophilic substitution and condensation reactions, making it a valuable intermediate in organic synthesis, especially in the preparation of various pharmaceuticals and agrochemicals. Additionally, it can undergo hydrolysis to form the corresponding acid and alcohol. Safety precautions should be taken when handling this compound, as it may pose health risks if inhaled or ingested, and appropriate protective equipment should be used.

Formula: C₆H₉ClO₃

InChI: InChI=1/C6H9ClO3/c1-3-10-6(9)5(7)4(2)8/h5H,3H2,1-2H3/t5-/m1/s1

InChI key: InChIKey=RDULEYWUGKOCMR-UHFFFAOYSA-N

SMILES: C(C(OCC)=O)(C(C)=O)Cl

Synonyms:

• 2-Chloro-3-oxobutanoic acid ethyl ester
• 2-Chloro-3-oxobutyric acid ethyl ester
• 2-Chloroacetoacetic acid ethyl ester
• A 21960
• Acetoacetic acid, 2-chloro-, ethyl ester
• Butanoic acid, 2-chloro-3-oxo-, ethyl ester
• Ethy 2-Chloroacetoacetate
• Ethyl 2-Chloro-3-Oxobutanoate
• Ethyl 2-chloracetoacetate
• Ethyl 2-chloro-3-oxobutyrate
• Ethyl α-chloroacetoacetate
• Ethyl α-chloroacetylacetate
• NSC 78426
• ethyl (2R)-2-chloro-3-oxobutanoate
• ethyl (2S)-2-chloro-3-oxobutanoate
• Ethyl-2-chloroacetoacetate
• Ethyl 2-chloroacetoacetate
• ETHYL ALPHA-CHLOROACETOACETATE
• ETHYL 2-CHLOROACETOACETATE, WACKERQUALIT Y
• Ethyl2-chloroacetoacetate,97%
• ETHYL CHLOROACETOACETATE
• 2-CL-ACE
• 2-CHLORACETYLETHYL ACETATE
• ETHYL A-CHLORO-ACETOACETATE
• ethyl2-chloroacettoacetate
• AKOS BBS-00004302
• A-CHLOROACETOACETIC ESTER
• 2-chloro-3-oxo-butanoicaciethylester

Ethyl 2-chloroacetoacetate, 96%

CAS: 609-15-4

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Formula: C₆H₉ClO₃

Purity: 96%

Color and Shape: Clear, colourless to yellow, liquid

Molecular weight: 164.59

Ref: 02-A19810

Ethyl 2-chloroacetoacetate

CAS: 609-15-4

Formula: C₆H₉ClO₃

Purity: 95%

Color and Shape: Liquid

Molecular weight: 164.5869

Ref: IN-DA0034UI

Ethyl 2-chloroacetoacetate

CAS: 609-15-4

Formula: C₆H₉ClO₃

Purity: ≥ 95.0%

Color and Shape: Clear, colourless to yellow liquid

Molecular weight: 164.59

Ref: 7W-GK6552

A 21960

CAS: 609-15-4

A 21960

Purity: ≥98%

Molecular weight: 164.59g/mol

Ref: 54-BUP19427

A 21960

CAS: 609-15-4

A 21960, or Ethyl 2-chloroacetoacetate, blocks synapse formation and site-specific recombination, aiding in bacterial infection research.

Formula: C₆H₉ClO₃

Purity: 99.46%

Color and Shape: Solid

Molecular weight: 164.59

Ref: TM-T26408

Febuxostat Impurity 61

CAS: 609-15-4

Formula: C₆H₉ClO₃

Color and Shape: Colorless Liquid

Molecular weight: 164.59

Ref: 4Z-F-3973

Ethyl 2-Chloroacetoacetate

CAS: 609-15-4

Formula: C₆H₉ClO₃

Purity: >95.0%(GC)

Color and Shape: Colorless to Light orange to Yellow clear liquid

Molecular weight: 164.59

Ref: 3B-C1218

Ethyl 2-chloroacetoacetate

CAS: 609-15-4

Ethyl 2-chloroacetoacetate

Formula: C₆H₉ClO₃

Purity: 98%

Color and Shape: colourless liquid

Molecular weight: 164.58686g/mol

Ref: 54-OR5481

Ethyl 2-Chloracetoacetate

CAS: 609-15-4

Applications Ethyl 2-Chloracetoacetate is used in the preparation of oxazoles and thiazoles as agonists for peroxisome proliferator-activated receptor δ. It is also used to synthesize dimethylimidazothiadiazolecarbohydrazides with anticancer activities.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sznaidman, M., et al.: Bioorg. Med. chem. Lett., 13, 1517 (2003); Terzioglu, N., et al.: Eur. J. Med. Chem., 38, 781 (2003)

Formula: C₆H₉ClO₃

Color and Shape: Neat

Molecular weight: 164.59

Ref: TR-E903485

Ethyl Chloroacetoacetate

CAS: 609-15-4

Formula: C₆H₉ClO₃

Purity: 95%

Color and Shape: Clear

Molecular weight: 164.59

Ref: 10-F069254

Ethyl 2-chloroacetoacetate

CAS: 609-15-4

Ethyl 2-chloroacetoacetate is an organic compound that is prepared industrially by the chlorination of acetoacetic acid. It has been shown to have antimicrobial activity against human pathogens, such as Staphylococcus aureus and Escherichia coli. The kinetic constants for this reaction are pH dependent and depend on the ionic strength of the solution. Ethyl 2-chloroacetoacetate reacts with hydroxide to form ethyl chlorocarbonate, which is hydrolyzed to give carbon dioxide and hydrogen chloride. The hydrogen bonding interactions between these two molecules are important in the mechanism of this reaction. This reaction also generates a characteristic NMR spectrum in which six peaks can be seen. Ethyl 2-chloroacetoacetate is acidic and hemolytic when dissolved in water, but it does not react with trifluoroacetic acid or low energy radiation.

Formula: C₆H₉ClO₃

Purity: Min. 95%

Color and Shape: Clear Liquid

Molecular weight: 164.59 g/mol

Ref: 3D-FE36663

Ethyl 2-Chloracetoacetate

CAS: 609-15-4

Formula: C₆H₉ClO₃

Molecular weight: 164.59

Ref: ST-EA-CP-F7031