CAS 60924-38-1

Pleuromutilin-22-mesylate

Description:

Pleuromutilin-22-mesylate is a semi-synthetic derivative of pleuromutilin, an antibiotic originally derived from the fungus *Pleurotus mutilus*. This compound exhibits potent antibacterial activity, particularly against Gram-positive bacteria, including strains resistant to other antibiotics. Its mechanism of action involves binding to the bacterial ribosome, inhibiting protein synthesis, which is crucial for bacterial growth and reproduction. Pleuromutilin-22-mesylate is characterized by its unique structure, which includes a pleuromutilin core modified with a mesylate group, enhancing its pharmacological properties and solubility. This modification contributes to its stability and bioavailability, making it suitable for therapeutic applications. The compound is typically administered in a clinical setting for treating infections, particularly in cases where conventional antibiotics may fail. As with many antibiotics, careful consideration of resistance patterns and appropriate usage is essential to maintain its efficacy. Overall, pleuromutilin-22-mesylate represents a valuable addition to the arsenal of antimicrobial agents, particularly in the face of rising antibiotic resistance.

Formula: C₂₃H₃₆O₇S

InChI: InChI=1/C23H36O7S/c1-7-21(4)12-17(30-18(25)13-29-31(6,27)28)22(5)14(2)8-10-23(15(3)20(21)26)11-9-16(24)19(22)23/h7,14-15,17,19-20,26H,1,8-13H2,2-6H3/t14-,15+,17-,19+,20+,21-,22+,23+/m1/s1

InChI key: InChIKey=IKVZCNHNKCXZHZ-PQZCNZKKSA-N

SMILES: C[C@@H]1[C@]23[C@]([C@](C)([C@H](OC(COS(C)(=O)=O)=O)C[C@](C=C)(C)[C@H]1O)[C@H](C)CC2)(C(=O)CC3)[H]

Synonyms:

• 2-[(Methylsulfonyl)oxy]acetic acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• 3a,9-Propano-3aH-cyclopentacyclooctene, acetic acid deriv.
• Acetic acid, 2-[(methylsulfonyl)oxy]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Acetic acid, [(methylsulfonyl)oxy]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Acetic acid, [(methylsulfonyl)oxy]-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, [3aS-(3aα,4β,5α,6α,8β,9α,9aβ,10S*)]-
• Pleuromutilin mesylate
• Pleuromutilin 22-mesylate
• Pleuromutilin methanesulfonate
• 2-naphthalen-8-ylethanamine
• (3AS,4S,5S,7R,8R,9S,9aR,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-((methylsulfonyl)oxy)acetate
• Pleuromutilin-22-mesylateQ: What is
• RetapaMulin I
• Pleurotus ostreatus -22- methanesulfonate
• Pleuromutilin-22-mesylate Q: What is the storage condition of

(3AS,4S,5S,7R,8R,9S,9aR,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-((methylsulfonyl)oxy)acetate

CAS: 60924-38-1

(3AS,4S,5S,7R,8R,9S,9aR,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-((methylsulfonyl)oxy)acetate

Formula: C₂₃H₃₆O₇S

Purity: 95%

Molecular weight: 456.6

Ref: 54-OR1053451

(3AS,4S,5S,7R,8R,9S,9aR,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-((methylsulfonyl)oxy)acetate

CAS: 60924-38-1

Formula: C₂₃H₃₆O₇S

Purity: 95%

Color and Shape: Solid

Molecular weight: 456.5927

Ref: IN-DA00EJVC

(3AS,4S,5S,7R,8R,9S,9aR,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-((methylsulfonyl)oxy)acetate

CAS: 60924-38-1

(3AS,4S,5S,7R,8R,9S,9aR,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-((methylsulfonyl)oxy)acetate

Formula: C₂₃H₃₆O₇S

Purity: 95%

Molecular weight: 456.59

Ref: IN-DG446733

Pleuromutilin 22-Mesylate

Controlled Product

CAS: 60924-38-1

Formula: C₂₃H₃₆O₇S

Color and Shape: Neat

Molecular weight: 456.593

Ref: TR-P610510

Pleuromutilin-22-mesylate

CAS: 60924-38-1

Pleuromutilin-22-mesylate is a pleuromutilin derivative that inhibits bacterial growth by binding to the 50S ribosomal subunit. It has been shown to inhibit the growth of several Gram-positive and Gram-negative bacteria, including methicillin resistant staphylococcus aureus (MRSA). Pleuromutilin-22-mesylate is also active against Mycobacterium tuberculosis and Mycobacterium avium complex. This compound has been shown to be effective in animal studies as an antibacterial agent, with the potential for use as a phase transfer catalyst.

Formula: C₂₃H₃₆O₇S

Purity: Min. 95%

Molecular weight: 456.6 g/mol

Ref: 3D-KCA92438