CAS 61-01-8

2-Methoxy-N,N-dimethyl-10H-phenothiazine-10-propanamine

Description:

2-Methoxy-N,N-dimethyl-10H-phenothiazine-10-propanamine, commonly known as promethazine, is a phenothiazine derivative with notable antihistaminic properties. It is characterized by its ability to block H1 histamine receptors, making it effective in alleviating allergic reactions, motion sickness, and nausea. The compound exhibits a moderate lipophilicity, allowing it to cross the blood-brain barrier, which contributes to its sedative effects. Promethazine is typically administered in various forms, including tablets, syrups, and injections, and is often used in combination with other medications for enhanced therapeutic effects. Its chemical structure includes a phenothiazine core, which is essential for its pharmacological activity, along with a methoxy group and dimethylamino substituents that influence its potency and solubility. While generally well-tolerated, promethazine can cause side effects such as drowsiness, dry mouth, and potential cardiovascular effects, necessitating careful dosage and monitoring in clinical settings.

Formula: C₁₈H₂₂N₂OS

InChI: InChI=1S/C18H22N2OS/c1-19(2)11-6-12-20-15-7-4-5-8-17(15)22-18-10-9-14(21-3)13-16(18)20/h4-5,7-10,13H,6,11-12H2,1-3H3

InChI key: InChIKey=BRABPYPSZVCCLR-UHFFFAOYSA-N

SMILES: C(CCN(C)C)N1C=2C(SC=3C1=CC=CC3)=CC=C(OC)C2

Synonyms:

• 10-(3-Dimethylaminopropyl)-2-methoxyphenothiazine
• 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N-dimethyl-
• 2-Methoxy-10-(3'-dimethylaminopropyl)phenothiazine
• 2-Methoxy-N,N-dimethyl-10H-phenothiazine-10-propanamine
• 2-Methoxypromazine
• 3-(2-methoxy-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
• 4632Rp
• Methopromazinum
• Methopromazinum [INN-Latin]
• Methoxypromazine
• Metopromazina
• Metopromazina [INN-Spanish]
• Neoproma
• Phenothiazine, 10-(3-(dimethylamino)propyl)-2-methoxy
• Rp 4632
• Tenton
• Tentone

2-Methoxy Promazine

CAS: 61-01-8

Formula: C₁₈H₂₂N₂OS

Color and Shape: White To Off-White Solid

Molecular weight: 314.45

Ref: 4Z-P-117003

2-Methoxy promazine

Controlled Product

CAS: 61-01-8

2-Methoxy promazine is a phenothiazine antipsychotic drug which has been used to treat chronic schizophrenia. It binds to the D2 receptor, and it is one of the most potent antipsychotic drugs for this receptor. 2-Methoxy promazine also binds to dopamine receptors, with a binding constant of 0.1 nM. 2-Methoxy promazine may be useful in the treatment of bowel disease because it has been shown to decrease bowel motility and increase colonic tone. 2-Methoxy promazine is not metabolized by cytochrome P450 enzymes, but it does have photochemical properties that can cause skin damage when exposed to sunlight. It is also an analog of promethazine, which belongs to the class of phenothiazine drugs. Promethazine is synthesized from 2-methylaminophenol and methylamine through a series of transfer reactions and hydrogen bonding.

Formula: C₁₈H₂₂N₂OS

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 314.45 g/mol

Ref: 3D-FM34072