CAS 61086-18-8

Noralfentanil

Description:

Noralfentanil is a synthetic opioid analgesic that is structurally related to fentanyl, a potent pain-relieving medication. It is classified as a mu-opioid receptor agonist, which means it binds to and activates these receptors in the brain, leading to effects such as pain relief, sedation, and euphoria. Noralfentanil is known for its high potency, which is significantly greater than that of morphine, making it effective in clinical settings for managing severe pain. The substance is typically administered in a controlled medical environment due to its potential for abuse and dependence. Its pharmacokinetics involve rapid onset and a relatively short duration of action, which can necessitate careful dosing and monitoring. Additionally, noralfentanil's safety profile includes risks of respiratory depression, especially at higher doses or when combined with other central nervous system depressants. As with other opioids, the use of noralfentanil is subject to strict regulatory controls in many countries due to its potential for misuse and addiction.

Formula: C₁₆H₂₄N₂O₂

InChI: InChI=1S/C16H24N2O2/c1-3-15(19)18(14-7-5-4-6-8-14)16(13-20-2)9-11-17-12-10-16/h4-8,17H,3,9-13H2,1-2H3

InChI key: InChIKey=ULOZGJWEIWAWML-UHFFFAOYSA-N

SMILES: N(C(CC)=O)(C1(COC)CCNCC1)C2=CC=CC=C2

Synonyms:

• Noralfentanil
• Norsufentanil
• Propanamide, N-[4-(methoxymethyl)-4-piperidinyl]-N-phenyl-
• N-[4-(Methoxymethyl)-4-piperidinyl]-N-phenylpropanamide
• R 30451
• N-[4-(methoxymethyl)piperidin-4-yl]-N-phenylpropionamide
• N-[4-(methoxymethyl)piperidin-4-yl]-N-phenylpropanamide
• Sufentanil EP Impurity A

Noralfentanil-d3 Hydrochloride

Controlled Product

CAS: 61086-18-8

Formula: C₁₆D₃H₂₁N₂O₂·HCl

Color and Shape: Neat

Molecular weight: 315.853

Ref: TR-N660802

Noralfentanil-d3 hydrochloride

Controlled Product

CAS: 61086-18-8

Noralfentanil-d3 hydrochloride is a highly selective and potent mu-opioid receptor agonist. It is used for the treatment of moderate to severe pain. Noralfentanil-d3 hydrochloride binds to the mu opioid receptors in the human liver, leading to reduced production of a number of proteins that are responsible for drug metabolism. Noralfentanil-d3 hydrochloride has been shown to be effective in clinical trials with a sample preparation technique involving liquid chromatography and p450 isozyme activity. This drug also has a number of chemical interactions, which may lead to an increased risk of toxicity or side effects. Molecular modeling studies have shown that noralfentanil-d3 hydrochloride interacts with amine groups on proteins, leading to its binding affinity with the mu opioid receptor.

Formula: C₁₆H₂₄N₂O₂

Purity: Min. 95%

Molecular weight: 276.37 g/mol

Ref: 3D-LCA08618

Sufentanil Citrate EP Impurity A

CAS: 61086-18-8

Formula: C₁₆H₂₄N₂O₂

Molecular weight: 276.38

Ref: ST-EA-CP-S35001