CAS 611-60-9

ddTTP

Description:

ddTTP, or 2',3'-dideoxythymidine triphosphate, is a nucleotide analog that plays a significant role in molecular biology and biochemistry. It is a modified form of thymidine triphosphate (dTTP), where the hydroxyl groups at the 2' and 3' positions of the ribose sugar are replaced with hydrogen atoms. This structural modification renders ddTTP unable to participate in further elongation of the DNA strand during replication, making it a valuable tool in research and therapeutic applications, particularly in the study of viral infections and cancer. ddTTP is often used in chain-termination assays, such as Sanger sequencing, where its incorporation leads to the termination of DNA synthesis. The compound is typically supplied as a salt, and its stability and solubility are important for its effective use in laboratory settings. As a nucleotide analog, ddTTP can also exhibit antiviral properties, particularly against retroviruses, by inhibiting viral DNA synthesis. Overall, ddTTP is a crucial reagent in molecular biology, enabling researchers to explore DNA synthesis and its implications in various biological processes.

Formula: C₁₀H₁₇N₂O₁₃P₃

InChI: InChI=1S/C10H17N2O13P3/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17)/t7-,8+/m0/s1

InChI key: InChIKey=URGJWIFLBWJRMF-JGVFFNPUSA-N

SMILES: O=C1N([C@@H]2O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)CC2)C=C(C)C(=O)N1

Synonyms:

• Thymidine, 3′-deoxy-, 5′-triphosphate
• 3′-Deoxythymidine 5′-(tetrahydrogen triphosphate)
• Thymidine, 3′-deoxy-, 5′-(tetrahydrogen triphosphate)
• Thymidine 5′-(tetrahydrogen triphosphate), 3′-deoxy-
• 2′,3′-Dideoxy TTP

ddTTP

CAS: 611-60-9

ddTTP, a 2',3'-dideoxyribonucleoside 5'-triphosphate (ddNTP), serves as a chain-elongation inhibitor of DNA polymerase in DNA sequencing [1].

Formula: C₁₀H₁₇N₂O₁₃P₃

Color and Shape: Solid

Molecular weight: 466.17

Ref: TM-T74108

3'-Deoxy-thymidine 5'-(Tetrahydrogen Triphosphate) Triethylammonium Salt

Controlled Product

CAS: 611-60-9

Formula: C₁₀H₁₇N₂O₁₃P₃•3(C₆H₁₅N)

Color and Shape: Neat

Molecular weight: 567.1148

Ref: TR-D281780