CAS 611168-24-2

Glycerol phenylbutyrate

Description:

Glycerol phenylbutyrate (CAS 611168-24-2) is a synthetic compound that serves as a prodrug of phenylbutyric acid, primarily used in the treatment of urea cycle disorders. It is characterized by its ability to facilitate the excretion of excess nitrogen from the body, thereby helping to manage hyperammonemia. The compound is a colorless to pale yellow liquid that is soluble in water and exhibits a sweet taste. Glycerol phenylbutyrate is known for its relatively low toxicity and favorable pharmacokinetic profile, which includes rapid absorption and metabolism. It is typically administered orally and is often formulated as a syrup for ease of use, particularly in pediatric populations. The compound's mechanism of action involves the conjugation of phenylbutyric acid with glutamine, leading to the formation of non-toxic metabolites that can be excreted via the kidneys. Overall, glycerol phenylbutyrate represents an important therapeutic option for managing metabolic disorders associated with ammonia accumulation.

Formula: C₃₃H₃₈O₆

InChI: InChI=1S/C33H38O6/c34-31(22-10-19-27-13-4-1-5-14-27)37-25-30(39-33(36)24-12-21-29-17-8-3-9-18-29)26-38-32(35)23-11-20-28-15-6-2-7-16-28/h1-9,13-18,30H,10-12,19-26H2

InChI key: InChIKey=ZSDBFLMJVAGKOU-UHFFFAOYSA-N

SMILES: C(OC(CCCC1=CC=CC=C1)=O)(COC(CCCC2=CC=CC=C2)=O)COC(CCCC3=CC=CC=C3)=O

Synonyms:

• HPN 100
• Benzenebutanoic acid, 1,1′,1′′-(1,2,3-propanetriyl) ester
• Tri(4-phenylbutyryl)glycerol
• Benzenebutanoic acid, 1,2,3-propanetriyl ester
• Glycerol phenylbutyrate

Glycerol phenylbutyrate

CAS: 611168-24-2

Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).

Formula: C₃₃H₃₈O₆

Purity: 98.54% - 99.74%

Color and Shape: Solid

Molecular weight: 530.65

Ref: TM-T15393

Glycerol phenylbutyrate

CAS: 611168-24-2

Formula: C₃₃H₃₈O₆

Purity: 97%

Color and Shape: Liquid

Molecular weight: 530.6512

Ref: IN-DA003AS3

Glycerol phenylbutyrate

CAS: 611168-24-2

Glycerol phenylbutyrate

Purity: ≥98%

Molecular weight: 530.65g/mol

Ref: 54-BUP15733

Tri(4-phenylbutyryl) Glycerol

CAS: 611168-24-2

Formula: C₃₃H₃₈O₆

Molecular weight: 530.66

Ref: 4Z-G-3877

Tri(4-phenylbutyryl)glycerol

CAS: 611168-24-2

Applications Tri(4-phenylbutyryl)glycerol is a drug that is currently under development for treatment of urea cyclic disorders (UCDs). It works by preventing the harmful buildup of ammonia in the body.
References Rockey, D.C., et al.: Hepatology, 59, 1073 (2014); Diaz, G.A., et al.: Hepatology, 57, 2171 (2013)

Formula: C₃₃H₃₈O₆

Color and Shape: Colourless

Molecular weight: 530.65

Ref: TR-T808810

Tri(4-phenylbutyryl)glycerol-d5

Controlled Product

CAS: 611168-24-2

Applications Tri(4-phenylbutyryl)glycerol-d5 is the isotope labelled analog of Tri(4-phenylbutyryl)glycerol (T808810); a drug that is currently under development for treatment of urea cyclic disorders (UCDs). It works by preventing the harmful buildup of ammonia in the body.
References Rockey, D.C., et al.: Hepatology, 59, 1073 (2014); Diaz, G.A., et al.: Hepatology, 57, 2171 (2013)

Formula: C₃₃D₅H₃₃O₆

Color and Shape: Neat

Molecular weight: 535.682

Ref: TR-T808812