CAS 611168-24-2: Glycerol phenylbutyrate

Description: Glycerol phenylbutyrate (CAS 611168-24-2) is a synthetic compound that serves as a prodrug of phenylbutyric acid, primarily used in the treatment of urea cycle disorders. It is characterized by its ability to facilitate the excretion of excess nitrogen from the body, thereby helping to manage hyperammonemia. The compound is a colorless to pale yellow liquid that is soluble in water and exhibits a sweet taste. Glycerol phenylbutyrate is known for its relatively low toxicity and favorable pharmacokinetic profile, which includes rapid absorption and metabolism. It is typically administered orally and is often formulated as a syrup for ease of use, particularly in pediatric populations. The compound's mechanism of action involves the conjugation of phenylbutyric acid with glutamine, leading to the formation of non-toxic metabolites that can be excreted via the kidneys. Overall, glycerol phenylbutyrate represents an important therapeutic option for managing metabolic disorders associated with ammonia accumulation.

Formula: C₃₃H₃₈O₆

InChI: InChI=1S/C33H38O6/c34-31(22-10-19-27-13-4-1-5-14-27)37-25-30(39-33(36)24-12-21-29-17-8-3-9-18-29)26-38-32(35)23-11-20-28-15-6-2-7-16-28/h1-9,13-18,30H,10-12,19-26H2

InChI key: InChIKey=ZSDBFLMJVAGKOU-UHFFFAOYSA-N

SMILES: O=C(OCC(OC(=O)CCCC=1C=CC=CC1)COC(=O)CCCC=2C=CC=CC2)CCCC=3C=CC=CC3

Synonyms:

• HPN 100
• Benzenebutanoic acid, 1,1′,1′′-(1,2,3-propanetriyl) ester
• Tri(4-phenylbutyryl)glycerol
• Benzenebutanoic acid, 1,2,3-propanetriyl ester
• Glycerol phenylbutyrate

Glycerol phenylbutyrate

CAS: 611168-24-2

Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is …

• Formula: C₃₃H₃₈O₆
• Purity: 99.00% - 99.74%
• Color and Shape: Solid
• Molecular weight: 530.65

Glycerol phenylbutyrate

CAS: 611168-24-2

• Formula: C₃₃H₃₈O₆
• Purity: 97%
• Color and Shape: Liquid
• Molecular weight: 530.6512

Tri(4-phenylbutyryl) Glycerol

CAS: 611168-24-2

• Formula: C₃₃H₃₈O₆
• Molecular weight: 530.66

Tri(4-phenylbutyryl)glycerol

CAS: 611168-24-2

Applications Tri(4-phenylbutyryl)glycerol is a drug that is currently under development for treatment of urea cyclic …

• Formula: C₃₃H₃₈O₆
• Color and Shape: Colourless
• Molecular weight: 530.65

Tri(4-phenylbutyryl)glycerol-d5

CAS: 611168-24-2

Applications Tri(4-phenylbutyryl)glycerol-d5 is the isotope labelled analog of Tri(4-phenylbutyryl)glycerol (T808810); a drug that is currently …

• Formula: C₃₃D₅H₃₃O₆
• Color and Shape: Neat
• Molecular weight: 535.682

Tri(4-phenylbutyryl)glycerol-d5

CAS: 611168-24-2

Tri(4-phenylbutyryl)glycerol (TBPG) is a metabolite of the lipid triacylglycerol. TBPG has been shown to be …

• Formula: C₃₃H₃₃D₅O₆
• Purity: Min. 95%
• Molecular weight: 535.68 g/mol