CAS 6112-76-1
:6-Mercaptopurine monohydrate
Description:
6-Mercaptopurine monohydrate is a purine analog and an antimetabolite used primarily in the treatment of certain types of leukemia and autoimmune diseases. It is characterized by its chemical formula C5H6N4S·H2O, indicating the presence of a mercapto group (-SH) that contributes to its reactivity and biological activity. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration in clinical settings. Its mechanism of action involves the inhibition of purine nucleotide synthesis, thereby interfering with DNA and RNA synthesis, which is crucial for rapidly dividing cells. 6-Mercaptopurine is often administered in conjunction with other medications to enhance therapeutic efficacy and reduce the risk of resistance. Due to its potential for toxicity, careful monitoring of blood counts and liver function is essential during treatment. Additionally, it is important to consider genetic factors, such as variations in the TPMT enzyme, which can affect individual responses to the drug.
Formula:C5H4N4S·H2O
InChI:InChI=1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2
InChI key:InChIKey=WFFQYWAAEWLHJC-UHFFFAOYSA-N
SMILES:S=C1C2=C(NC=N1)N=CN2.O
Synonyms:- 1,4,5,7-Tetrahydro-6H-Purine-6-Thione Hydrate
- 1,7-Dihydro-6H-Purin-6-Thion,Monohydrat
- 1,7-Dihydro-6H-Purine-6-Thionemonohydrate
- 1,7-Dihydro-6H-Purine-6-Thionmonohydrate
- 3,7-Dihydro-6H-Purine-6-Thione Hydrate
- 6-Mercapto Purine
- 6-Mercaptopurine Hydrate
- 6-Merkaptopurin,Monohydrat
- 6-Purinethiol Monohydrate
- 6-Thiohypoxanthine Monohydrate
- 6H-Purin-6-Thion,Monohydrat
- 6H-Purine-6-thione, 1,2,3,9-tetrahydro-, hydrate (1:1)
- 6H-Purine-6-thione, 1,7-dihydro-, monohydrate
- 7H-Purine-6-Thiolate
- 9H-Purine-6-thiol hydrate
- Leukerin Monohydrate
- Mercaleukin Monohydrate
- Mercaptopurine Monohydrate, 6-Mercaptopurine
- Mercaptopurine, Monohydrate
- Purin-6-Thiol,Monohydrat
- Purine-6-Thiol, Monohydrate
- Xaluprine
- 6-Mercaptopurine monohydrate
- See more synonyms
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Mercaptopurine impurity standard
CAS:Mercaptopurine impurity standard is a drug product that is used as an analytical reference standard in the development of drugs. Mercaptopurine impurity standard is a natural metabolite of 6-mercaptopurine, which is used to treat leukemia and other forms of cancer. It has been shown to have an anti-inflammatory effect, but this has not been confirmed. Mercaptopurine impurity standard is a synthetic compound that is made synthetically for use as an impurity standard. It has also been shown to be metabolized by cytochrome P450 enzymes, glutathione reductase, or conjugation with glucuronic acid. Mercaptopurine impurity standard has been shown to be stable under acidic conditions and heat treatment at temperatures up to 200°C.Purity:Min. 95%
