CAS 61145-67-3

(8R,10R,13S)-6-bromo-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione

Description:

The chemical substance known as "(8R,10R,13S)-6-bromo-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione," with the CAS number 61145-67-3, is a complex organic compound characterized by its polycyclic structure, which includes multiple fused rings. This compound features a bromine atom, contributing to its reactivity and potential biological activity. The presence of two methyl groups indicates that it has branching, which can influence its physical properties, such as solubility and melting point. The dione functional groups suggest that it may participate in various chemical reactions, including oxidation and reduction processes. Its stereochemistry, denoted by the specific R and S configurations, implies that it may exhibit chirality, potentially leading to different biological activities depending on the enantiomer. Overall, this compound's unique structural features make it of interest in fields such as medicinal chemistry and organic synthesis, where it may serve as a precursor or a target for further chemical modifications.

Formula: C₁₉H₂₅BrO₂

InChI: InChI=1/C19H25BrO2/c1-18-7-5-11(21)9-15(18)16(20)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16H,3-8,10H2,1-2H3/t12-,13?,14?,16?,18+,19-/m0/s1

Synonyms:

• 6α-Bromo-androstenedione

6a-Bromo Androstenedione

Controlled Product

CAS: 61145-67-3

Applications Androstenedione (A637550) analog, an aromatase inhibitor.
References Marsh, D.A., et al.: J. Med. Chem., 28, 788 (1985),

Formula: C₁₉H₂₅BrO₂

Color and Shape: Neat

Molecular weight: 365.30

Ref: TR-B679700

6a-Bromo androstenedione

Controlled Product

CAS: 61145-67-3

6a-Bromo androstenedione is a nonsteroidal, non-aromatizable, competitive inhibitor of aromatase. It binds to the active site of the enzyme and blocks the conversion of testosterone to estradiol. 6a-Bromo androstenedione has been shown to inhibit aromatase activity in vitro at an IC50 of about 5 nM. The affinity for the enzyme is about 10 times higher than that for aminoglutethimide, which is another competitive inhibitor of aromatase. 6a-Bromo androstenedione has also been shown to have inhibitory activity against estrogen synthetase in rats.

Formula: C₁₉H₂₅BrO₂

Purity: Min. 95%

Molecular weight: 365.3 g/mol

Ref: 3D-FB19020