CAS 61177-45-5

Potassium clavulanate

Description:

Potassium clavulanate is a beta-lactam compound that serves as a potent inhibitor of beta-lactamase enzymes, which are produced by certain bacteria to confer resistance against beta-lactam antibiotics. It is commonly used in combination with penicillin antibiotics, such as amoxicillin, to enhance their efficacy against resistant bacterial strains. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its use in pharmaceutical formulations. Its mechanism of action involves the irreversible binding to the active site of beta-lactamases, thereby preventing the hydrolysis of beta-lactam antibiotics and allowing them to exert their antibacterial effects. Potassium clavulanate is generally well-tolerated, although it may cause side effects in some individuals, including gastrointestinal disturbances. It is important to note that while it enhances the effectiveness of antibiotics, it does not possess significant antibacterial activity on its own. As a pharmaceutical agent, it is crucial to use potassium clavulanate under medical supervision to ensure appropriate dosing and to mitigate potential adverse effects.

Formula: C₈H₉NO₅·K

InChI: InChI=1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/b4-1-;/t6-,7-;/m1./s1

InChI key: InChIKey=FERIANDDKNFRJI-JSYANWSFSA-N

SMILES: C(O)(=O)[C@@H]\1N2[C@](O/C1=C\CO)(CC2=O)[H].[K]

Synonyms:

• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R,3Z,5R)-
• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, [2R-(2α,3Z,5α)]-
• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, potassium salt (1:1), (2R,3Z,5R)-
• Brl 14151K
• Clavitesse
• Clavulanic acid potassium salt
• Potassium clavulanate
• Serdaxin
• potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate

potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate

CAS: 61177-45-5

Formula: C₈H₈KNO₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 237.2511

Ref: IN-DA0035ID

Potassium Clavulanate

CAS: 61177-45-5

Formula: C₈H₈NO₅·K

Color and Shape: White To Off-White Solid

Molecular weight: 198.16 39.10

Ref: 4Z-C-328

Potassium clavulanate with microcrystalline cellulose

CAS: 61177-45-5

Formula: C₈H₈NO₅K

Purity: Clavulanic acid: 38.3 - 45.0 %

Color and Shape: White or almost white powder

Molecular weight: 237.25

Ref: 7W-GA1260

Clavulanate:Cellulose

CAS: 61177-45-5

Clavulanate:Cellulose

Formula: C₈H₈NO₅·K

Color and Shape: white or almost white crystalline powder

Molecular weight: 237.25g/mol

Ref: 54-BIC581

Clavulanic acid potassium

CAS: 61177-45-5

Formula: C₈H₈NO₅·K

Color and Shape: Neat

Molecular weight: 237.25

Ref: 04-C11668545

Clavulanic Acid Potassium Salt

CAS: 61177-45-5

Stability Hygroscopic, Temperature sensitive
Applications Clavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977), Ball, A.P., et al.: Lancet, 1, 620 (1980), Brogden, R.N., et al. Drugs, 22, 337 (1981)

Formula: C₈H₈NO₅·K

Color and Shape: Light Yellow To Dark Brown

Molecular weight: 237.25

Ref: TR-C563750

Potassium clavulanate - 1:1 mixture with silicon dioxide

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor that is used in the treatment of bacterial infections. The active site of potassium clavulanate is the beta-lactam ring, which has an ester bond to the 4-hydroxyl group of the penicillin nucleus. This bond can be hydrolyzed by beta-lactamase, an enzyme produced by bacteria, which will render the antibiotic ineffective. Potassium clavulanate inhibits this enzyme by binding to it and preventing it from breaking down penicillin. The temperature range for potassium clavulanate is between 2°C and 30°C, and its UV spectrophotometric technique ranges from 220 nm to 350 nm.

Formula: C₈H₈NO₅·K

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 237.25 g/mol

Ref: 3D-FP30769

Potassium clavulanate - 1:1 mixture with cellulose

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor that is used in the treatment of bacterial infections. The active site of potassium clavulanate is the beta-lactam ring, which has an ester bond to the 4-hydroxyl group of the penicillin nucleus. This bond can be hydrolyzed by beta-lactamase, an enzyme produced by bacteria, which will render the antibiotic ineffective. Potassium clavulanate inhibits this enzyme by binding to it and preventing it from breaking down penicillin. The temperature range for potassium clavulanate is between 2°C and 30°C, and its UV spectrophotometric technique ranges from 220 nm to 350 nm.

Formula: C₈H₈NO₅·K

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 237.25 g/mol

Ref: 3D-FP16197

Clavulanate potassium

CAS: 61177-45-5

Clavulanate potassium,β-Lactamase inhibitor with antibiotic activity.

Formula: C₈H₈KNO₅

Color and Shape: Solid

Molecular weight: 237.25

Ref: TM-T67431

Potassium clavulanate (40%) : silicon dioxide mixture

CAS: 61177-45-5

Formula: C₈H₈KNO₅

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 237.252

Ref: 10-F237796

Clavulanic Acid Potassium Salt in Cellulose (1:1 mixture)

CAS: 61177-45-5

Applications Clavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
References Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977), Ball, A.P., et al.: Lancet, 1, 620 (1980), Brogden, R.N., et al. Drugs, 22, 337 (1981)

Formula: C₈H₈NO₅·K

Color and Shape: Mixture

Molecular weight: 237.25

Ref: TR-C563751

Potassium clavulanate - 1:1 mixture with cellulose, Antibiotic for Culture Media Use Only

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor and an antibacterial agent. The presence of potassium clavulanate in culture media inhibits the activity of beta-lactamases, which are enzymes that confer resistance to penicillin and other beta-lactam antibiotics. It also has been shown to be active against bacterial infections such as tuberculosis, sepsis, and pneumonia, where it can inhibit the growth of bacteria by interfering with their ability to form cell walls.

Formula: C₈H₈KNO₅

Purity: Min. 95.0 Area-%

Molecular weight: 237.25 g/mol

Ref: 3D-W-105420

Potassium clavulanate

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor and an antibacterial agent. The presence of potassium clavulanate in culture media inhibits the activity of beta-lactamases, which are enzymes that confer resistance to penicillin and other beta-lactam antibiotics. It also has been shown to be active against bacterial infections such as tuberculosis, sepsis, and pneumonia, where it can inhibit the growth of bacteria by interfering with their ability to form cell walls. Potassium clavulanate is also used as an antimicrobial agent for blood culture technique and antimicrobial treatment.

Formula: C₈H₈NO₅·K

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 237.25 g/mol

Ref: 3D-FP10878