CAS 612548-45-5

Perindopril L-arginine

Description:

Perindopril L-arginine is a pharmaceutical compound primarily used as an antihypertensive agent. It is a combination of perindopril, an angiotensin-converting enzyme (ACE) inhibitor, and L-arginine, an amino acid that plays a role in nitric oxide synthesis and vascular function. This compound is characterized by its ability to lower blood pressure and improve cardiovascular health by relaxing blood vessels and reducing the workload on the heart. Perindopril itself is a prodrug that is converted in the body to its active form, which inhibits the ACE enzyme, leading to decreased levels of angiotensin II, a potent vasoconstrictor. The presence of L-arginine may enhance the overall efficacy of the treatment by promoting endothelial function and improving blood flow. Perindopril L-arginine is typically administered orally and is often prescribed for conditions such as hypertension and heart failure. Its pharmacokinetics, safety profile, and potential side effects are similar to those of perindopril, with the added benefits associated with L-arginine supplementation.

Formula: C₁₉H₃₂N₂O₅·C₆H₁₄N₄O₂

InChI: InChI=1S/C19H32N2O5.C6H14N4O2/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24;7-4(5(11)12)2-1-3-10-6(8)9/h12-16,20H,4-11H2,1-3H3,(H,23,24);4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t12-,13-,14-,15-,16-;4-/m00/s1

InChI key: InChIKey=RYCSJJXKEWBUTI-YDYAIEMNSA-N

SMILES: C([C@@H](N[C@H](C(OCC)=O)CCC)C)(=O)N1[C@@]2([C@](C[C@H]1C(O)=O)(CCCC2)[H])[H].C(CCNC(=N)N)[C@@H](C(O)=O)N

Synonyms:

• Perindopril L-arginine
• L-Arginine, mono[(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylate]
• L-Arginine, (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylate (1:1)

Perindopril L-arginine

CAS: 612548-45-5

Formula: C₂₅H₄₆N₆O₇

Purity: 95%

Color and Shape: Solid

Molecular weight: 542.6687

Ref: IN-DA00EFC7

Perindopril L-Arginine

CAS: 612548-45-5

Formula: C₁₉H₃₂N₂O₅·C₆H₁₄N₄O₂

Purity: ≥ 98.0%

Color and Shape: White to off-white powder or solid

Molecular weight: 542.67

Ref: 7W-GP3059

Perindopril L-Arginine

CAS: 612548-45-5

Formula: C₁₉H₃₂N₂O₅·C₆H₁₄N₄O₂

Color and Shape: White To Off-White Solid

Molecular weight: 368.47 174.20

Ref: 4Z-P-0640

Perindopril arginine

CAS: 612548-45-5

Perindopril arginine, an ACE inhibitor, and amlodipine, a calcium channel blocker, treat hypertension.

Formula: C₂₅H₄₆N₆O₇

Color and Shape: Solid

Molecular weight: 542.68

Ref: TM-T69001

Perindopril L-Arginine

CAS: 612548-45-5

Stability Hygroscopic
Applications Perindopril L-Arginine, is a complex compound of Perindopril (P287500), having the antihypertensive, cardiovascular protective and antithrombotic properties, and has been shown to exists as a neutral complex.
References Remko, M., et al.: Euro. J. Med. Chem., 44, 101 (2009); Morgan, T., et al.: J. Cardiovasc. Pharmacol., 10, Supp. 7, S116, (1987);

Formula: C₂₅H₄₆N₆O₇

Color and Shape: White To Off-White

Molecular weight: 542.67

Ref: TR-P287600

Perindopril L-Arginine

CAS: 612548-45-5

Formula: C₁₉H₃₂N₂O₅C₆H₁₄N₄O₂

Molecular weight: 368.47 : 174.20

Ref: ST-EA-CP-P18013

Perindopril L-arginine

CAS: 612548-45-5

Perindopril L-arginine is an angiotensin-converting enzyme (ACE) inhibitor, which is synthetically derived for pharmacological applications. Its mode of action involves the inhibition of the ACE, reducing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. Consequently, this results in vasodilation, decreased blood pressure, and reduced cardiac workload. The addition of L-arginine aims to enhance endothelial function due to its role as a precursor to nitric oxide, a vasodilator that further complements the antihypertensive effects.

Formula: C₂₅H₄₆N₆O₇

Purity: Min. 95%

Molecular weight: 542.7 g/mol

Ref: 3D-MZA54845