CAS 612847-09-3

1-{1-[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one

Description:

The chemical substance known as 1-{1-[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one, with the CAS number 612847-09-3, is a complex organic compound characterized by its multi-ring structure and the presence of various functional groups. This compound features a benzimidazole core, which is known for its biological activity, and incorporates a piperidine moiety that contributes to its pharmacological properties. The imidazoquinoxaline component suggests potential interactions with biological targets, possibly indicating its role in medicinal chemistry. The presence of a phenyl group enhances its lipophilicity, which may influence its absorption and distribution in biological systems. Overall, this compound is of interest in research, particularly in the fields of drug development and molecular pharmacology, due to its intricate structure and potential therapeutic applications. Further studies would be necessary to elucidate its specific biological activities and mechanisms of action.

Formula: C₃₄H₂₉N₇O

InChI: InChI=1/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)

SMILES: c1ccc(cc1)c1c(c2ccc(cc2)CN2CCC(CC2)n2c3ccccc3nc2O)nc2cc3c(cc2n1)nc[nH]3

Synonyms:

• 1-{1-[4-(7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
• 2H-benzimidazol-2-one, 1,3-dihydro-1-[1-[[4-(7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]-4-piperidinyl]-
• 3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one
• Akti-1/2

AKT inhibitor VIII

CAS: 612847-09-3

AKT inhibitor VIII (AKTi-1/2) is a highly specific Akt1/2 inhibitor (IC50: 58/210 nM). The selectivity for Akt1 is higher about 36-fold than Akt3.

Formula: C₃₄H₂₉N₇O

Purity: 98.31% - 98.65%

Color and Shape: Pale Yellow Solid

Molecular weight: 551.64

Ref: TM-T3346

Akti-1/2

CAS: 612847-09-3

Formula: C₃₄H₂₉N₇O

Molecular weight: 551.65

Ref: 4Z-K-031076

AKT Inhibitor VIII

CAS: 612847-09-3

Purity: 97%

Molecular weight: 551.6539917

Ref: 10-F875657

Akti-1/2

Controlled Product

CAS: 612847-09-3

Akti-1/2 is a potential anticancer agent that inhibits growth and induces apoptosis in cancer cells. Akti-1/2 has been shown to induce autophagy, which is the process by which cells degrade cellular components, leading to increased mitochondrial membrane potential and inhibition of cell death. Akti-1/2 also activates cyclin D2 and MCL-1 protein expression, which are important for cell cycle progression. Akti-1/2 has inhibitory properties against the proliferation of cancer cells in vitro and synergistic effects with chemical inhibitors. This drug may be useful for the treatment of eye disorders such as macular degeneration or retinitis pigmentosa.

Formula: C₃₄H₂₉N₇O

Purity: Min. 95%

Molecular weight: 551.64 g/mol

Ref: 3D-FA17246