CAS 61318-91-0

sulconazole nitrate

Description:

Sulconazole nitrate is an antifungal agent primarily used in the treatment of dermatological infections, particularly those caused by fungi and yeast. It belongs to the class of imidazole derivatives, which are known for their ability to inhibit the synthesis of ergosterol, a critical component of fungal cell membranes. This mechanism disrupts the integrity of the fungal cell, leading to cell death. Sulconazole nitrate is typically formulated as a topical cream or solution, allowing for localized treatment with minimal systemic absorption. The compound is characterized by its relatively low solubility in water, which enhances its efficacy in topical applications. Additionally, it exhibits a broad spectrum of antifungal activity against various pathogens, making it a valuable option in clinical settings. Safety profiles indicate that it is generally well-tolerated, with side effects being rare and typically mild. As with any medication, it is essential to use sulconazole nitrate as directed by a healthcare professional to ensure optimal therapeutic outcomes and minimize the risk of resistance development.

Formula: C₁₈H₁₆Cl₃N₃O₃S

InChI: InChI=1/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)

InChI key: InChIKey=CRKGMGQUHDNAPB-UHFFFAOYSA-N

SMILES: C(CN1C=CN=C1)(SCC2=CC=C(Cl)C=C2)C3=C(Cl)C=C(Cl)C=C3.N(=O)(=O)O

Synonyms:

• 1-[2-(4-Chlorobenzylthio)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole nitrate
• 1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-, (±)-, mononitrate
• 1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-, nitrate (1:1)
• Exelderm
• Rs 44872
• Rs 44872-00-10-3
• Sulcosyn
• Sulconazole nitrate
• Myk
• rs44872
• 1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-, nitrate (9CI)
• Sulconazole Nitrate (200 mg)
• 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazol
• SULCONAZOLE NITRATE SALT
• ,mononitrate,(+-)-
• Sulconazole (mononitrate)
• Sulconazole nitrate,cas:61318-91-0
• 1H-IMidazole, 1-[2-[[(4-chlorophenyl)Methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-, nitrate
• 1-[2-(P-CHLOROBENZYLTHIO)-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE NITRATE
• Sulconazole nitrate salt,1-(2-[p-Chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole
• Sulconazole nitrate USP/EP/BP
• 1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-, mononitrate (9CI)
• (+-)-1-(2,4-dichloro-beta-((4-chlorobenzyl)thio)phenethyl)imidazolenitrate
• 1-(2-[p-chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1h-imidazole
• 1-[2-[(4-chlorophenyl)methylthio]-2-(2,4-dichlorophenyl)ethyl]imidazole

Sulconazole Nitrate

CAS: 61318-91-0

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure nesoi

Formula: C₁₈H₁₅Cl₃N₂S

Color and Shape: White Off-White Powder

Molecular weight: 396.00215

Ref: 45-1623681

SULCONAZOLENITRATE

CAS: 61318-91-0

Formula: C₁₈H₁₆Cl₃N₃O₃S

Purity: 95%

Color and Shape: Solid

Molecular weight: 460.7619

Ref: IN-DA00IAU9

Sulconazole mononitrate

CAS: 61318-91-0

Sulconazole mononitrate

Purity: ≥98%

Molecular weight: 460.76g/mol

Ref: 54-BUP13871

Sulconazole Nitrate

CAS: 61318-91-0

Sulconazole Nitrate

Purity: 99%

Molecular weight: 460.75g/mol

Ref: 54-OR1030138

Sulconazole nitrate salt

CAS: 61318-91-0

Formula: C₁₈H₁₅Cl₃N₂S·HNO₃

Purity: ≥ 98.0%

Color and Shape: White powder

Molecular weight: 460.76

Ref: 7W-GA8662

Sulconazole Nitrate

CAS: 61318-90-9, 61318-91-0

Formula: C₁₈H₁₅Cl₃N₂S·HNO₃

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 460.75

Ref: 3B-U0112

Sulconazole Nitrate

Controlled Product

CAS: 61318-91-0

Formula: C₁₈H₁₅Cl₃N₂S·HNO₃

Color and Shape: Neat

Molecular weight: 460.76

Ref: 86-MM3674.00

Sulconazole mononitrate

CAS: 61318-91-0

"Sulconazole mononitrate (Exelderm) is a synthetic antifungal imidazole that disrupts fungal cell membranes by inhibiting ergosterol synthesis."

Formula: C₁₈H₁₅Cl₃N₂S·HNO₃

Purity: 99.75% - 99.92%

Color and Shape: White Crystalline Powder

Molecular weight: 460.76

Ref: TM-T6686

Sulconazole Nitrate

Controlled Product

CAS: 61318-91-0

Applications Sulconazole Nitrate is an antifungal agent which prevents fungal growth by inhibiting sterol synthesis.
References Kinobe, R. et al.: J. Pharmacol. Exp. Ther., 319, 277 (2006); Ooishi, T. et al.: J. Japan. Soc. Hosp. Pharm., 31, 1449 (1995);

Formula: C₁₈H₁₅Cl₃N₂S·HNO₃

Color and Shape: Neat

Molecular weight: 460.76

Ref: TR-S688940

Sulconazole Nitrate

CAS: 61318-91-0

Sulconazole Nitrate is a broad-spectrum antimicrobial agent that inhibits the growth of fungi by interfering with the synthesis of ergosterol, an important component of fungal cell membranes. Sulconazole Nitrate has been shown to possess in vitro antifungal activity against dimorphic fungi such as Candida albicans and Cryptococcus neoformans. It also has been shown to inhibit the growth of bacteria and other microbes through inhibition of fatty acid synthesis. This drug may be used as an adjuvant therapy for autoimmune diseases or infections caused by resistant strains of bacteria. Sulconazole Nitrate binds to fatty acids in the plasma membrane and prevents their incorporation into the phospholipid bilayer. The disruption of this process results in decreased cell membrane fluidity, which leads to a loss of structural integrity and cell permeability.

Formula: C₁₈H₁₅Cl₃N₂S·HNO₃

Purity: Min. 95%

Molecular weight: 460.76 g/mol

Ref: 3D-FS76681