CAS 61370-88-5

(Des-Tyr1)-Met-Enkephalin

Description:

(Des-Tyr1)-Met-Enkephalin, also known as a derivative of the enkephalin family of peptides, is a pentapeptide that plays a significant role in the body's pain modulation and opioid receptor activity. It is characterized by its structure, which consists of five amino acids, specifically lacking the tyrosine residue at the first position, hence the prefix "Des-Tyr." This modification influences its binding affinity and activity at opioid receptors, particularly the mu-opioid receptor, which is crucial for analgesic effects. The peptide is hydrophilic, which affects its solubility and interaction with biological membranes. (Des-Tyr1)-Met-Enkephalin is often studied for its potential therapeutic applications in pain management and its role in the central nervous system. Its CAS number, 61370-88-5, is a unique identifier that facilitates its recognition in chemical databases. Overall, this compound exemplifies the complexity of peptide interactions in biological systems and highlights the importance of structural modifications in pharmacological activity.

Formula: C₁₈H₂₆N₄O₅S

InChI: InChI=1/C18H26N4O5S/c1-28-8-7-13(18(26)27)22-17(25)14(9-12-5-3-2-4-6-12)21-16(24)11-20-15(23)10-19/h2-6,13-14H,7-11,19H2,1H3,(H,20,23)(H,21,24)(H,22,25)(H,26,27)/t13-,14-/m0/s1

SMILES: CSCC[C@@H](C(=O)O)N=C([C@H](Cc1ccccc1)N=C(CN=C(CN)O)O)O

Synonyms:

• H-Gly-Gly-Phe-Met-OH
• glycylglycyl-L-phenylalanyl-L-methionine

(Des-Tyr1)-Met-Enkephalin

CAS: 61370-88-5

Des-Tyr1-Met-Enkephalin H-Gly-Gly-Phe-Met-OH is a peptide that is derived from the endorphin family. It has been shown to have both amnestic and enkephalin effects, which may be due to its antagonistic effect on naloxone. This endogenous peptide has been studied in a dose response curve, with an increase in amnesia and decrease in memory retention as the dose increases. Des-Tyr1-Met-Enkephalin H-Gly-Gly-Phe-Met-OH also binds to receptors at the same sites as other substances such as epinephrine, β endorphin, and behavioral effects are observed.

Formula: C₁₈H₂₆N₄O₅S

Purity: Min. 95%

Molecular weight: 410.49 g/mol

Ref: 3D-FD111020