CAS 61379-65-5

Rifamycin, 3-[[(4-cyclopentyl-1-piperazinyl)imino]methyl]-

Description:

Rifamycin, 3-[[(4-cyclopentyl-1-piperazinyl)imino]methyl]- is a synthetic derivative of rifamycin, a class of antibiotics known for their efficacy against bacterial infections, particularly those caused by Mycobacterium tuberculosis. This compound features a complex structure that includes a rifamycin core, which is characterized by a naphthalenic ring system and a characteristic ansa bridge. The presence of the 4-cyclopentyl-1-piperazinyl group enhances its pharmacological properties, potentially improving its ability to penetrate bacterial cell walls and interact with RNA polymerase, thereby inhibiting bacterial RNA synthesis. The CAS number 61379-65-5 uniquely identifies this compound in chemical databases, facilitating research and regulatory processes. Rifamycin derivatives are often explored for their therapeutic potential, particularly in treating resistant strains of bacteria, and their structural modifications can influence their antibacterial activity, solubility, and bioavailability. As with many antibiotics, the development and use of this compound must be carefully managed to mitigate the risk of resistance development in bacterial populations.

Formula: C₄₇H₆₄N₄O₁₂

InChI: InChI=1/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,48,53-55,57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14+,32-23+/t24-,26+,27-,28-,33+,38-,39-,43-,47+/m1/s1

InChI key: InChIKey=WDZCUPBHRAEYDL-LYDPARFQSA-N

SMILES: OC1=C2C3=C4O[C@@](C)(C3=O)O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(\C)/C(=O)NC(C(O)=C2C(O)=C4C)=C1C=NN5CCN(CC5)C6CCCC6

Synonyms:

• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.
• 3-[[(4-Cyclopentyl-1-piperazinyl)imino]methyl]rifamycin
• Antibiotic DL 473IT
• Cyclopentylrifampicin
• Dl 473
• Ktc 1
• Mdl 473
• Prifitin
• Priftin
• R 77-3
• Rifamycin AF/ACPP
• Rifapentin
• Rifapentina
• Rifapentine
• (2S,8E,16S,17S,18R,19R,20S,21S,22S,23S,24E)-8-{[(4-cyclopentylpiperazin-1-yl)amino]methylidene}-5,6,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,9,11-trioxo-1,2,8,9-tetrahydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
• (2S,8E,16R,17R,18R,19R,20R,21S,22S,23S,24E)-8-{[(4-cyclopentylpiperazin-1-yl)amino]methylidene}-5,6,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,9,11-trioxo-1,2,8,9-tetrahydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
• Rifamycin, 3-[[(4-cyclopentyl-1-piperazinyl)imino]methyl]-
• r-773
• antibioticdl473it
• rifamycinaf/acpp
• 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)-rifamyci
• 3-(4-cyclopentyl-1-piperazinyl)iminomethylrifamycinsv
• ktc1
• PIFAPENTINE
• Rifapenti
• 3 & 4-NONENES & 4-NONANOL
• 3-[(4-Cyclopentylpiperazino)iminomethyl]rifamycin
• Rifapention
• dl473
• Rifapentine(Priftin)
• 3-[[(4-Cy-dopentyl-1piperazinyl)imino]methyl]rifamycin

Rifamycin, 3-[[(4-cyclopentyl-1-piperazinyl)imino]methyl]-

CAS: 61379-65-5

Formula: C₄₇H₆₄N₄O₁₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 877.0307

Ref: IN-DA00IAUQ

Rifapentine

CAS: 61379-65-5

Rifapentine (Rifapentinum) is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.

Formula: C₄₇H₆₄N₄O₁₂

Purity: 95.74% - ≥98%

Color and Shape: Solid

Molecular weight: 877.03

Ref: TM-T1629

Rifapentine

CAS: 61379-65-5

Formula: C₄₇H₆₄N₄O₂

Purity: (HPLC) ≥ 95.0%

Color and Shape: Red to dark red-brown crystalline powder

Molecular weight: 717.04

Ref: 7W-GA1653

Rifapentine-15N

CAS: 61379-65-5

Formula: C₄₇H₆₄N₃₁₅NO₁₂

Color and Shape: Red Solid

Molecular weight: 878.04

Ref: 4Z-R-090009

Rifapentine

CAS: 61379-65-5

Rifapentine

Purity: ≥80%

Molecular weight: 877.03g/mol

Ref: 54-BUP13980

Rifapentine

CAS: 61379-65-5

Formula: C₄₇H₆₄N₄O₁₂

Color and Shape: Brownish-Red Solid

Molecular weight: 877.05

Ref: 4Z-R-090001

Rifampicin S-Na Sodium

CAS: 61379-65-5

Rifampicin S-Na Sodium

Purity: 97%

Molecular weight: 877.03g/mol

Ref: 54-OR1029983

Rifapentine-d9

CAS: 61379-65-5

Formula: C₄₇H₅₅D₉N₄O₁₂

Color and Shape: Red Solid

Molecular weight: 886.10

Ref: 4Z-R-090005

Rifapentine

CAS: 61379-65-5

Formula: C₄₇H₆₄N₄O₁₂

Purity: >98.0%(HPLC)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 877.05

Ref: 3B-R0198

Rifapentine-D8

Controlled Product

CAS: 61379-65-5

Formula: C₄₇H₅₆D₈N₄O₁₂

Color and Shape: Neat

Molecular weight: 885.08

Ref: TR-R508508

Rifapentine

CAS: 61379-65-5

Applications Semi-synthetic rifamycin. Antibacterial (tuberculostatic).
References Arioli, V., et al.: J. Antibiot., 34, 1026 (1981), Neu, H.C., et al.: Antimicrob. Agents Chemother., 24, 457 (1983), Assandri, A., et al.: J. Antibiot., 37, 1066 (1984), Jarvis, B., et al.: Drugs, 56, 607 (1998),

Formula: C₄₇H₆₄N₄O₁₂

Color and Shape: Red

Molecular weight: 877.03

Ref: TR-R508500

Rifapentine N-Oxide

Controlled Product

CAS: 61379-65-5

Applications Rifampicin N-Oxide is related to Rifapentine(R508500) a compound with antibacterial properties.
References Arioli, V., et al.: J. Antibiot., 34, 1026 (1981), Neu, H.C., et al.: Antimicrob. Agents Chemother., 24, 457 (1983)

Formula: C₄₇H₆₄N₄O₁₃

Color and Shape: Dark Red To Dark Brown

Molecular weight: 893.03

Ref: TR-R508025

Rifapentine

CAS: 61379-65-5

Rifapentine is a rifamycin antibiotic with action on bacterial RNA polymerase to inhibit transcription and is used for treating active and latent tuberculosis.

Formula: C₄₇H₆₄N₄O₁₂

Purity: Min. 75 Area-%

Color and Shape: Orange Red Powder

Molecular weight: 877.03 g/mol

Ref: 3D-AR27731