CAS 614-80-2

2-Acetamidophenol

Description:

2-Acetamidophenol, also known as paracetamol or acetaminophen, is an organic compound with the molecular formula C8H9NO2. It is characterized by its white crystalline appearance and is soluble in water, alcohol, and ether. This compound features an acetamido group (-NHCOCH3) attached to a phenolic ring, which contributes to its analgesic and antipyretic properties. 2-Acetamidophenol is widely used in pharmaceuticals as a pain reliever and fever reducer, making it a common ingredient in over-the-counter medications. Its mechanism of action involves the inhibition of cyclooxygenase enzymes, leading to a decrease in the synthesis of prostaglandins, which are mediators of pain and inflammation. While generally considered safe when used as directed, excessive consumption can lead to hepatotoxicity due to the formation of toxic metabolites. The compound is also subject to regulatory scrutiny, and its use should be monitored, especially in vulnerable populations such as children and individuals with liver conditions.

Formula: C₈H₉NO₂

InChI: InChI=1S/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10)

InChI key: InChIKey=ADVGKWPZRIDURE-UHFFFAOYSA-N

SMILES: N(C(C)=O)C1=C(O)C=CC=C1

Synonyms:

• 2'-Hydroxyacetanilide
• 2-(Acetylamino)phenol
• 2-(N-Acetylamino)phenol
• 2-Acetamido Phenol
• 2-Acetamido-Pheno
• 2-Acetamidophenol
• 2-Acetamino Phenol
• 2-Acetaminophenol
• 2-Acetylaminophenol
• 2-Hydroxyanilid kyseliny octove
• 2-Hydroxyanilidkyselinyoctove
• 2’-Hydroxy-Acetanilid
• Acet-o-aminofenol
• Acetamide, N-(2-hydroxyphenyl)-
• Acetanilide, 2'-hydroxy-
• Acetanilide, o-hydroxy-
• Akos Bbb/377
• N-Acetyl-2-aminophenol
• N-Acetyl-o-aminophenol
• NSC 3989
• O-Acetamido Phenol
• O-Acetamidophenol
• O-Acetaminophenol
• O-Alkyl Acetophenylamine
• O-Hydroxyacetanilide
• Orthocetamol
• o-(Acetylamino)phenol

2'-Hydroxyacetanilide

CAS: 614-80-2

Formula: C₈H₉NO₂

Purity: >99.0%(HPLC)(N)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 151.17

Ref: 3B-H0189

2-Acetamidophenol, 97%

CAS: 614-80-2

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₈H₉NO₂

Purity: 97%

Color and Shape: Powder, Pale cream to cream to dark brown to brown

Molecular weight: 151.17

Ref: 02-B21264

Acetaminophen Related Compound C (N-(2-hydroxyphenyl)acetamide)

CAS: 614-80-2

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof, nesoi

Formula: C₈H₉NO₂

Color and Shape: Tan Powder

Molecular weight: 151.06333

Ref: 45-1003031

2-Acetamidophenol

CAS: 614-80-2

Formula: C₈H₉NO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 151.1626

Ref: IN-DA003GAL

2-Acetamidophenol

CAS: 614-80-2

Formula: C₈H₉NO₂

Purity: ≥ 97.0%

Color and Shape: Beige to tan-yellow or brown powder

Molecular weight: 151.17

Ref: 7W-GK8656

2-Acetamidophenol

CAS: 614-80-2

2-Acetamidophenol (Orthocetamol) has analgesic and antipyretic effects. 2-Acetamidophenol is an isomer of Paracetamol (4-acetamidophenol).

Formula: C₈H₉NO₂

Purity: 99.93%

Color and Shape: Yellow Solid

Molecular weight: 151.1626

Ref: TM-T7238

Paracetamol EP Impurity A (Acetaminophen USP Related Compound C)

CAS: 614-80-2

Formula: C₈H₉NO₂

Color and Shape: Brown Solid

Molecular weight: 151.17

Ref: 4Z-A-0215

2-Acetamidophenol

CAS: 614-80-2

2-Acetamidophenol

Formula: C₈H₉NO₂

Purity: ≥98%

Molecular weight: 151.16

Ref: 54-BUP18894

2-Acetamidophenol

Controlled Product

CAS: 614-80-2

Formula: C₈H₉NO₂

Color and Shape: Neat

Molecular weight: 151.16

Ref: 04-C10011860

N-(2-Hydroxyphenyl)acetamide (2-Acetamidophenol)

Controlled Product

CAS: 614-80-2

Formula: C₈H₉NO₂

Color and Shape: Neat

Molecular weight: 151.16

Ref: 86-MM0042.08

2-Acetamidophenol

Controlled Product

CAS: 614-80-2

Impurity Paracetamol EP Impurity A
Applications 2-Acetamidophenol is an impurity of Acetaminophen (A161220). Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches, and arthritis (1,2).
References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974)

Formula: C₈H₉NO₂

Color and Shape: Neat

Molecular weight: 151.16

Ref: TR-A158490

2-Acetamidophenol

CAS: 614-80-2

2-Acetamidophenol

Formula: C₈H₉NO₂

Purity: >98%

Molecular weight: 151.16256

Ref: 54-OR25860

Acetaminophen USP Related Compound C

CAS: 614-80-2

Formula: C₈H₉NO₂

Molecular weight: 151.17

Ref: ST-EA-CP-A7006

Paracetamol EP Impurity A

CAS: 614-80-2

Formula: C₈H₉NO₂

Molecular weight: 151.17

Ref: ST-EA-CP-P10001

2-Acetamidophenol

CAS: 614-80-2

Ref: BE-RMCA031006

2-Acetamidophenol, min. 98%

CAS: 614-80-2

Formula: C₈H₉NO₂

Purity: min. 98%

Color and Shape: Off-white solid

Molecular weight: 151.17

Ref: 08-07-0077

2-Acetamidophenol

CAS: 614-80-2

N-(2-Hydroxyphenyl)acetamide

Formula: C₈H₉NO₂

Purity: 97%

Molecular weight: 151.16

Ref: IN-DG69381

N-(2-Hydroxyphenyl)acetamide

CAS: 614-80-2

Formula: C₈H₉NO₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 151.165

Ref: 10-F242846

2-Acetamidophenol

CAS: 614-80-2

2-Acetamidophenol is an apoptotic agent that has been used as a hydroxyl radical scavenger in the treatment of oxidative injury. The drug has also been shown to possess anti-inflammatory properties. 2-Acetamidophenol is a stable complex with nitrite ion, which is formed during the redox cycle and may be responsible for the drug's antirheumatic activity. The drug does not react with p-hydroxybenzoic acid, which may be due to its protective effect on enzymes such as cytochrome P450 that are involved in the metabolism of drugs. 2-Acetamidophenol can be detected by analytical methods such as nmr spectra or gas chromatography under neutral pH conditions.

Formula: C₈H₉NO₂

Purity: Min. 95%

Molecular weight: 151.16 g/mol

Ref: 3D-FA16942