CAS 61422-45-5

Carmofur

Description:

Carmofur, with the CAS number 61422-45-5, is a synthetic compound primarily recognized for its application in cancer treatment, particularly in the management of colorectal cancer. It is classified as a fluorinated derivative of uracil, which is a pyrimidine nucleobase. Carmofur exhibits antitumor activity by inhibiting the enzyme thymidylate synthase, thereby interfering with DNA synthesis and cell proliferation. The compound is typically administered orally and is known for its relatively low toxicity compared to other chemotherapeutic agents. In addition to its anticancer properties, Carmofur has also been studied for its potential neuroprotective effects, particularly in neurodegenerative diseases. Its chemical structure includes a fluorine atom, which contributes to its biological activity. As with many pharmaceuticals, the use of Carmofur may be accompanied by side effects, and its efficacy can vary among individuals. Overall, Carmofur represents a significant compound in the field of oncology and continues to be the subject of research for its therapeutic potential.

Formula: C₁₁H₁₆FN₃O₃

InChI: InChI=1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)

InChI key: InChIKey=AOCCBINRVIKJHY-UHFFFAOYSA-N

SMILES: C(NCCCCCC)(=O)N1C(=O)NC(=O)C(F)=C1

Synonyms:

• 1(2H)-pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-
• 1-(Hexylcarbamoyl)-5-fluorouracil
• 1-(Hexylcarbamyl)-5-fluorouracil
• 1-(n-Hexylcarbamoyl)-5-fluorouracil
• 5-Fluoro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide
• 5-Fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinecarboxamide
• 61422-45-5
• Mifurol
• Yamaful
• HCFU

1(2H)-Pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-

CAS: 61422-45-5

Formula: C₁₁H₁₆FN₃O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 257.2614

Ref: IN-DA00IMEU

Carmofur

CAS: 61422-45-5

Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.

Formula: C₁₁H₁₆FN₃O₃

Purity: 98.53% - 99.98%

Color and Shape: Solid

Molecular weight: 257.26

Ref: TM-T1307

5-Fluoro-1-(hexylcarbamoyl)uracil

CAS: 61422-45-5

5-Fluoro-1-(hexylcarbamoyl)uracil

Purity: 98.5%

Molecular weight: 257.26g/mol

Ref: 54-PC0659

Carmofure

CAS: 61422-45-5

Formula: C₁₁H₁₆FN₃O₃

Purity: ≥ 98.0%

Color and Shape: White or off-white powder

Molecular weight: 257.26

Ref: 7W-GP5925

Carmofur

CAS: 61422-45-5

Carmofur

Purity: ≥98%

Molecular weight: 257.26g/mol

Ref: 54-BUP16271

Carmofur

CAS: 61422-45-5

Formula: C₁₁H₁₆FN₃O₃

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 257.27

Ref: 3B-C2663

Carmofur

Controlled Product

CAS: 61422-45-5

Applications Carmofur is a derivative of fluorouracil (F596002) an is an antineoplastic agent showing antitumor activity against several cells including L1210 leukemia and L5178Y lymphoma cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hoshi, A., et al.: J. Pharmacobio-dynam., 3, 478 (1980);

Formula: C₁₁H₁₆FN₃O₃

Color and Shape: Neat

Molecular weight: 257.26

Ref: TR-C183700

Carmofur

CAS: 61422-45-5

Formula: C₁₁H₁₆FN₃O₃

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 257.265

Ref: 10-F547240

Carmofur-d11

Controlled Product

CAS: 61422-45-5

Formula: C₁₁D₁₁H₅FN₃O₃

Color and Shape: Neat

Molecular weight: 268.329

Ref: TR-C183702

Carmofur

CAS: 61422-45-5

Carmofur is a fluorouracil derivative that interferes with nucleotide metabolism and consequently with synthesis of RNA and DNA, leading to cytotoxic and antineoplastic effects. Carmofur inhibits also other enzymes such as lysosomal acid ceramidase and the main protease from coronaviruses. For the SARS-CoV-2 main protease Mpro, carmofur was characterised as a covalent inhibitor with IC50 of 1.82 μM and EC50 of 24.30 μM.

Formula: C₁₁H₁₆FN₃O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 257.26 g/mol

Ref: 3D-FC60423

Carmofur - Bio-X ™

CAS: 61422-45-5

Carmofur is an antineoplastic agent that is used to treat various cancers such as breast and colorectal cancer. This drug is a derivative of fluorouracil. Carmofur is an inhibitor of the human acid ceramidase, a lysosomal amidase involved in the development of cancer cells.

Formula: C₁₁H₁₆FN₃O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 257.26 g/mol

Ref: 3D-BC164286