CAS 61443-77-4

2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepin-8-ol

Description:

2-Chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepin-8-ol, with CAS number 61443-77-4, is a chemical compound that belongs to the class of dibenzo[b,f][1,4]oxazepines. This compound features a complex structure characterized by a dibenzodiazepine core, which is fused with an oxazepine ring. The presence of a chlorine atom and a 4-methylpiperazine moiety contributes to its unique pharmacological properties. Typically, compounds of this class exhibit potential neuroactive effects, making them of interest in medicinal chemistry, particularly in the development of psychotropic medications. The hydroxyl group (-OH) at the 8-position may enhance solubility and influence the compound's biological activity. Its synthesis and characterization involve standard organic chemistry techniques, and it may be studied for its interactions with neurotransmitter systems. As with many such compounds, safety and handling precautions are essential due to potential toxicity and the need for proper laboratory practices.

Formula: C₁₈H₁₈ClN₃O₂

InChI: InChI=1/C18H18ClN3O2/c1-21-6-8-22(9-7-21)18-14-10-12(19)2-4-16(14)24-17-5-3-13(23)11-15(17)20-18/h2-5,10-11,23H,6-9H2,1H3

SMILES: CN1CCN(CC1)C1=Nc2cc(ccc2Oc2ccc(cc12)Cl)O

Synonyms:

• 2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]oxazepin-8-ol
• Dibenz(b,f)(1,4)oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-

8-hydroxy Loxapine

CAS: 61443-77-4

8-hydroxy Loxapine can be used in related research in the field of life sciences. Its product number is T37163 and CAS number is 61443-77-4.

Formula: C₁₈H₁₈ClN₃O₂

Color and Shape: Solid

Molecular weight: 343.81

Ref: TM-T37163

8-Hydroxy-Loxapine-d8

CAS: 61443-77-4

Formula: C₁₈H₁₀D₈ClN₃O₂

Color and Shape: Pale Yellow Solid

Molecular weight: 351.86

Ref: 4Z-L-089011

8-Hydroxy Loxapine

CAS: 61443-77-4

Formula: C₁₈H₁₈ClN₃O₂

Color and Shape: Pale Yellow Solid

Molecular weight: 343.82

Ref: 4Z-L-089010

8-Hydroxy Loxapine

CAS: 61443-77-4

Stability Light Sensitive
Applications The inactive metabolite of Loxapine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bradford, M., et al.: Anal. Biochem., 72, 248 (1976), Fitton, A., et al.: Drugs, 40, 722 (1990), Jann, M., et al.: Clin. Pharmacokinet., 24, 161 (1993), Jennison, T., et al.: J. Anal. Toxicol., 21, 73 (1997),

Formula: C₁₈H₁₈ClN₃O₂

Color and Shape: Neat

Molecular weight: 343.81

Ref: TR-H943730

8-Hydroxy loxapine

CAS: 61443-77-4

8-Hydroxy loxapine is a drug that is used as an antipsychotic. It binds to the dopamine receptor in the brain and blocks its activity, which can lead to relief of some symptoms of schizophrenia. 8-Hydroxy loxapine has been shown to be effective against anesthetized rats, with a terminal half-life of about 1 hour. In clinical trials, this drug has been shown to have a good response in patients with Parkinson's disease and other extrapyramidal disorders. 8-Hydroxy loxapine is metabolized into an n-oxide in the liver and it binds to polymerase chain reaction (PCR) primers during bioanalysis. This drug also has regulatory approval for use as a nasal spray for treatment of agitation in elderly patients with dementia who are nonverbal or minimally verbal.

Formula: C₁₈H₁₈ClN₃O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 343.81 g/mol

Ref: 3D-FH24034

7-Hydroxy-loxapine-sulfate Sodium Salt

Controlled Product

CAS: 61443-77-4

Formula: C₁₈H₁₇ClN₃NaO₅S

Color and Shape: Neat

Molecular weight: 445.853

Ref: TR-H943935

8-Hydroxy-loxapine-sulfate Sodium Salt

Controlled Product

CAS: 61443-77-4

Formula: C₁₈H₁₇ClN₃NaO₅S

Color and Shape: Neat

Molecular weight: 445.853

Ref: TR-H943940