CAS 615-76-9

6-Aza-2-thiothymine

Description:

6-Aza-2-thiothymine, with the CAS number 615-76-9, is a nucleobase analog of thymine, which is one of the four primary components of DNA. This compound features a sulfur atom in place of the oxygen atom typically found in thymine, as well as a nitrogen atom replacing a carbon atom in the pyrimidine ring. Its structural modifications impart unique properties, making it of interest in biochemical research and potential therapeutic applications. 6-Aza-2-thiothymine exhibits characteristics such as increased stability under certain conditions and altered hydrogen bonding capabilities, which can influence its interactions with nucleic acids. Additionally, it may exhibit different solubility and reactivity profiles compared to thymine, impacting its utility in various chemical and biological contexts. The compound's ability to act as a substrate or inhibitor in enzymatic reactions is also a subject of investigation, particularly in the study of nucleic acid metabolism and the development of antiviral or anticancer agents. Overall, 6-Aza-2-thiothymine represents a valuable tool in the exploration of nucleobase function and modification.

Formula: C₄H₅N₃OS

InChI: InChI=1S/C4H5N3OS/c1-2-3(8)5-4(9)7-6-2/h1H3,(H2,5,7,8,9)

InChI key: InChIKey=NKOPQOSBROLOFP-UHFFFAOYSA-N

SMILES: O=C1C(C)=NNC(=S)N1

Synonyms:

• 1,2,4-Triazin-5(2H)-one, 3,4-dihydro-6-methyl-3-thioxo-
• 1,2,4-Triazin-5(2H)-one, 3,4-dihydro-6-methyl-3-thioxo- (9CI)
• 2-Thio-6-azathymine
• 3,4-Dihydro-6-methyl-3-thioxo-1,2,4-triazin-5(2H)-one
• 3-Mercapto-5-hydroxy-6-methyl-1,2,4-triazine
• 3-Mercapto-6-methyl-1,2,4-triazin-5(4H)-one
• 3-Mercapto-6-methyl-1,2,4-triazin-5-ol
• 3-Mercapto-6-methyl-as-triazin-5-ol
• 5-Methyl-2-thio-6-azauracil
• 6-Aza-2-thiothymine
• 6-Methyl-3-thio-as-triazine-3,5(2H,4H)-dione
• 6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one
• Nsc 102906
• Nsc 1609
• Nsc 38618
• as-Triazin-5-ol, 3-mercapto-6-methyl-
• as-Triazine-3,5(2H,4H)-dione, 6-methyl-3-thio-
• as-Triazine-3,5(2H,4H)-dione, 6-methyl-3-thio- (8CI)

6-Aza-2-thiothymine, 98%

CAS: 615-76-9

6-Aza-2-thiothymine is used in MALDI analysis of acidic glycans in negative ion mode. It is also called as pharmaceutical intermediates. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the l

Formula: C₄H₅N₃OS

Purity: 98%

Color and Shape: White to cream to pale yellow, Crystals or powder or crystalline powder

Molecular weight: 143.16

Ref: 02-A14167

6-Methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one

CAS: 615-76-9

Formula: C₄H₅N₃OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 143.1670

Ref: IN-DA0034BR

3-mercapto-6-methyl-1,2,4-triazin-5-ol

CAS: 615-76-9

3-mercapto-6-methyl-1,2,4-triazin-5-ol

Purity: 98%

Molecular weight: 143.16699g/mol

Ref: 54-OR29628

6-Methyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one

CAS: 615-76-9

6-Methyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one

Formula: C₄H₅N₃OS

Purity: 98%

Color and Shape: cream crystalline powder

Molecular weight: 143.17g/mol

Ref: 54-OR23879

6-Aza-2-thiothymine

CAS: 615-76-9

6-Aza-2-thiothymine is a hydrophobic base that is used in the preparation of DNA sequencing samples. It can be incorporated into DNA by enzymatic reactions with picolinic acid, which results in an increase in the number of thiol groups on the DNA. The incorporation of 6-aza-2-thiothymine into DNA is detected by binding to malonic acid and subsequent detection by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The presence of 6-aza-2-thiothymine can also be detected using a photochemical reaction with hydroxyl radicals, resulting in a change in the fluorescence properties of oligosaccharides bound to the DNA. This compound has been shown to inhibit prostate cancer cells and may be useful as a treatment for this type of cancer.

Formula: C₄H₅N₃OS

Color and Shape: White Powder

Molecular weight: 143.17 g/mol

Ref: 3D-FA76662

6-Methyl-3-thioxo-3,4-dihydro-2H-[1,2,4]triazin-5-one

CAS: 615-76-9

Purity: 98%

Molecular weight: 143.1600037

Ref: 10-F615084