CAS 6154-45-6

N-benzoyl-L-tyrosine-P-nitroanilide

Description:

N-benzoyl-L-tyrosine-P-nitroanilide, with the CAS number 6154-45-6, is a synthetic compound commonly used as a substrate in biochemical assays, particularly for the detection of proteolytic enzymes such as trypsin. This compound features a benzoyl group attached to the amino acid L-tyrosine, along with a P-nitroanilide moiety, which contributes to its chromogenic properties. When cleaved by specific enzymes, it releases a colored product, allowing for quantitative analysis. The compound is typically a solid at room temperature and is soluble in organic solvents, making it suitable for various laboratory applications. Its structure includes an aromatic ring system, which is characteristic of many chromogenic substrates, and it exhibits stability under standard laboratory conditions. Safety data sheets should be consulted for handling and storage guidelines, as with any chemical substance. Overall, N-benzoyl-L-tyrosine-P-nitroanilide serves as a valuable tool in enzymology and related fields.

Formula: C₂₂H₁₉N₃O₅

InChI: InChI=1/C22H19N3O5/c26-19-12-6-15(7-13-19)14-20(24-21(27)16-4-2-1-3-5-16)22(28)23-17-8-10-18(11-9-17)25(29)30/h1-13,20,26H,14H2,(H,23,28)(H,24,27)

SMILES: c1ccc(cc1)C(=NC(Cc1ccc(cc1)O)C(=O)Nc1ccc(cc1)N(=O)=O)O

Synonyms:

• Bz-Tyr-pNA
• Nalpha-benzoyl-N-(4-nitrophenyl)-L-tyrosinamide
• Nalpha-benzoyl-N-(4-nitrophenyl)tyrosinamide

Bz-Tyr-pNA

CAS: 6154-45-6

Substrate for the determination of chymotrypsin activity. It is also hydrolyzed by carboxypeptidase Y.

Formula: C₂₂H₁₉N₃O₅

Purity: ≥ 99%

Color and Shape: White Powder

Molecular weight: 405.41

Ref: 01-4001259

Bz-Tyr-pNA

CAS: 6154-45-6

Formula: C₂₂H₁₉N₃O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 405.4034

Ref: IN-DA00E9IJ

N-Benzoyl-L-tyrosine p-nitroanilide

CAS: 6154-45-6

N-Benzoyl-L-tyrosine p-nitroanilide

Purity: ≥95%

Molecular weight: 405.4g/mol

Ref: 54-OR1007478

Benzoyl-L-tyrosine 4-nitroanilide

Controlled Product

CAS: 6154-45-6

Formula: C₂₂H₁₉N₃O₅

Color and Shape: Neat

Molecular weight: 405.403

Ref: TR-B289605

Bz-Tyr-pNA

CAS: 6154-45-6

Bz-Tyr-pNA is a peptide that has been shown to inhibit the activity of serine proteases. The peptide consists of Boc-Tyr-Nal-pNA, which is an artificial amino acid that has been synthesized for use as a substrate in assays and as a probe in the study of protein structure and function. Bz-Tyr-pNA inhibits the enzyme activity of a recombinant human neutrophil elastase, with an IC50 of about 12.5 μM. This peptide also inhibits the catalytic action of human neutrophil elastase by binding to its active site and blocking access to the substrate Tyr-pNA. It has been shown that Bz-Tyr-pNA can be used as an immunosuppressant to prevent graft rejection, although it is not yet approved for this use.

Formula: C₂₂H₁₉N₃O₅

Purity: Min. 95%

Molecular weight: 405.4 g/mol

Ref: 3D-SYN-3015