CAS 61622-34-2

Cefotiam

Description:

Cefotiam is a broad-spectrum cephalosporin antibiotic, classified under the beta-lactam antibiotics. It is primarily used for the treatment of various bacterial infections, particularly those caused by Gram-positive and Gram-negative bacteria. Cefotiam exhibits a mechanism of action that involves inhibiting bacterial cell wall synthesis, leading to cell lysis and death. The compound is characterized by its stability against certain beta-lactamases, which enhances its efficacy against resistant bacterial strains. It is typically administered via injection and is known for its relatively low toxicity profile. Pharmacokinetically, cefotiam is well-absorbed and has a favorable distribution in body tissues, making it effective for treating infections in various sites. Common side effects may include gastrointestinal disturbances, allergic reactions, and, in rare cases, hematological abnormalities. As with all antibiotics, it is crucial to use cefotiam judiciously to prevent the development of antibiotic resistance. Overall, cefotiam is a valuable therapeutic agent in the arsenal against bacterial infections.

Formula: C₁₈H₂₃N₉O₄S₃

InChI: InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1

InChI key: InChIKey=QYQDKDWGWDOFFU-IUODEOHRSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CC=3N=C(N)SC3)=O)C2=O)(SCC1CSC=4N(CCN(C)C)N=NN4)[H]

Synonyms:

• (6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[(2-Amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}thio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (6R-trans)-
• 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (6R,7R)-
• 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (6R,7R)-
• 7b-[2-(Aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl]thio]methyl]ceph-3-em-4-carboxylic Acid
• 95789-30-3
• Cgp 14221E
• Sce 963

(6R,7R)-7-[2-(2-amino-1,3-thiazol-4-yl)acetamido]-3-[({1-[2-(dimethylamino)ethyl]-1H-1,2,3,4-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS: 61622-34-2

Formula: C₁₈H₂₃N₉O₄S₃

Color and Shape: Solid

Molecular weight: 525.6281

Ref: IN-DA00IAWG

Cefotiam

CAS: 61622-34-2

Cefotiam (SCE-963), a parenteral cephalosporin antibiotic, exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria [1] [2].

Formula: C₁₈H₂₃N₉O₄S₃

Color and Shape: Solid

Molecular weight: 525.63

Ref: TM-T75297

Cefotiam Dihydrochloride-13C, 15N2

Controlled Product

CAS: 61622-34-2, 66309-69-1

Applications Cefotiam Dihydrochloride-13C, 15N2 is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.
References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)

Formula: C₁₇CH₂₃N₇N₂O₄S₃•2x(HCl)

Color and Shape: Neat

Molecular weight: 601.5295

Ref: TR-C243007

Cefotiam

CAS: 61622-34-2

Cefotiam is a broad-spectrum cephalosporin antibiotic, which is a beta-lactam compound derived from the mold Acremonium. It functions by inhibiting bacterial cell wall synthesis, particularly by targeting penicillin-binding proteins, which leads to cell lysis and death in susceptible bacteria. This mechanism of action makes it effective against various Gram-positive and Gram-negative bacteria.

Formula: C₁₈H₂₃N₉O₄S₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 525.62 g/mol

Ref: 3D-AC183647