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CAS 61661-06-1

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(-)-Dobutamine

Description:
(-)-Dobutamine is a synthetic catecholamine and a potent beta-1 adrenergic agonist primarily used in clinical settings to treat heart failure and cardiogenic shock. It is characterized by its ability to increase cardiac output by enhancing myocardial contractility and heart rate without significantly affecting peripheral vascular resistance. The compound has a chiral center, and the (-)-enantiomer is the active form responsible for its therapeutic effects. In terms of its chemical structure, (-)-Dobutamine features a phenolic hydroxyl group, an amine group, and a butyl side chain, contributing to its solubility in water and its pharmacological activity. The substance is typically administered intravenously due to its rapid onset of action and short half-life, making it suitable for acute care settings. Side effects may include tachycardia, hypertension, and arrhythmias, necessitating careful monitoring during administration. Overall, (-)-Dobutamine plays a crucial role in managing specific cardiac conditions, highlighting its importance in modern pharmacotherapy.
Formula:C18H23NO3
InChI:InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3/t13-/m0/s1
InChI key:InChIKey=JRWZLRBJNMZMFE-ZDUSSCGKSA-N
SMILES:C(CN[C@H](CCC1=CC=C(O)C=C1)C)C2=CC(O)=C(O)C=C2
Synonyms:
  • 1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, (S)-
  • 4-[2-[[(1S)-3-(4-Hydroxyphenyl)-1-methylpropyl]amino]ethyl]-1,2-benzenediol
  • (-)-Dobutamine
  • 1,2-Benzenediol, 4-[2-[[(1S)-3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-
  • Levdobutamine
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