CAS 61714-27-0

W-7 Hydrochloride

Description:

W-7 Hydrochloride, with the CAS number 61714-27-0, is a synthetic compound known primarily as a calmodulin inhibitor. It is a derivative of the peptide W-7, which is designed to interfere with the calcium-binding protein calmodulin, thereby modulating various calcium-dependent cellular processes. This compound is typically characterized by its ability to inhibit calmodulin-mediated signal transduction pathways, making it a valuable tool in biochemical research, particularly in studies related to muscle contraction, neurotransmitter release, and cell proliferation. W-7 Hydrochloride is usually presented as a white to off-white crystalline powder and is soluble in water and organic solvents, which facilitates its use in various experimental setups. Safety data sheets indicate that, like many chemical substances, it should be handled with care, as it may pose health risks if ingested or inhaled. Overall, W-7 Hydrochloride serves as an important reagent in pharmacological and biochemical studies, contributing to the understanding of calcium signaling in cells.

Formula: C₁₆H₂₁ClN₂O₂S·ClH

InChI: InChI=1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H

InChI key: InChIKey=OMMOSRLIFSCDBL-UHFFFAOYSA-N

SMILES: S(NCCCCCCN)(=O)(=O)C=1C2=C(C(Cl)=CC=C2)C=CC1.Cl

Synonyms:

• W-7 Hydrochloride
• 1-Naphthalenesulfonamide, N-(6-aminohexyl)-5-chloro-, monohydrochloride
• NSC 683545
• W 7
• 1-Naphthalenesulfonamide, N-(6-aminohexyl)-5-chloro-, hydrochloride (1:1)

N-(6-Aminohexyl)-5-chloronaphthalene-1-sulfonamide hydrochloride

CAS: 61714-27-0

Formula: C₁₆H₂₂Cl₂N₂O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 377.3291

Ref: IN-DA003SDT

W-7 hydrochloride

CAS: 61714-27-0

Formula: C₁₆H₂₁ClN₂O₂SHCl

Molecular weight: 377.33

Ref: 7W-GA2769

W-7 hydrochloride

CAS: 61714-27-0

W-7 hydrochloride

Purity: ≥98%

Molecular weight: 377.32g/mol

Ref: 54-BUP11456

N-(6-Aminohexyl)-5-chloronaphthalene-1-sulphonamide hydrochloride

CAS: 61714-27-0

N-(6-Aminohexyl)-5-chloronaphthalene-1-sulphonamide hydrochloride

Formula: C₁₆H₂₁ClN₂O₂S·ClH

Purity: >98.0%

Molecular weight: 377.33g/mol

Ref: 54-OR1000T

W-7 hydrochloride

CAS: 61714-27-0

W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride

Formula: C₁₆H₂₂Cl₂N₂O₂S

Purity: 99.63%

Color and Shape: White Crystalline Solid

Molecular weight: 377.32

Ref: TM-T20792

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride

Controlled Product

CAS: 61714-27-0

Applications W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities.
References Hidaka, H., et al.: Proc. Nat. Acad. Sci. USA, 78, 4354 (1981)

Formula: C₁₆H₂₁ClN₂O₂S·ClH

Color and Shape: Neat

Molecular weight: 377.33

Ref: TR-A610000

N-(6-AMINOHEXYL)-5-CHLORONAPHTHALENE-1-SULFONAMIDE HCL

CAS: 61714-27-0

Purity: ≥98%(HPLC)

Molecular weight: 377.3200073

Ref: 10-F827085