CAS 61825-94-3

Oxaliplatin

Description:

Oxaliplatin is a platinum-based chemotherapy drug primarily used in the treatment of colorectal cancer. It is classified as a third-generation platinum compound and is known for its ability to form DNA cross-links, which inhibit DNA replication and transcription, ultimately leading to cancer cell death. Chemically, oxaliplatin is a diaminocyclohexane platinum complex, which enhances its efficacy and reduces the likelihood of resistance compared to earlier platinum drugs like cisplatin and carboplatin. It is typically administered intravenously and is often used in combination with other chemotherapeutic agents. Oxaliplatin is characterized by its moderate solubility in water and its stability under physiological conditions, although it can undergo hydrolysis in the presence of water, leading to the formation of reactive species. Common side effects include peripheral neuropathy, nausea, and myelosuppression. Its unique mechanism of action and side effect profile make it a valuable option in the oncological therapeutic arsenal, particularly for patients with advanced or metastatic colorectal cancer.

Formula: C₈H₁₄N₂O₄Pt

InChI: InChI=1/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1/rC8H14N2O4Pt/c11-7-8(12)14-15(13-7)9-5-3-1-2-4-6(5)10-15/h5-6H,1-4,9-10H2/t5-,6-/m1/s1

InChI key: InChIKey=ZROHGHOFXNOHSO-BNTLRKBRSA-L

SMILES: O=C1[O-][Pt+2]2([NH2][C@]3([C@]([NH2]2)(CCCC3)[H])[H])[O-]C1=O

Synonyms:

• Oxalato(trans-(-)-1,2-cyclohexanediamine)platinum(II)
• Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]-, (SP-4-2)-
• platinum(2+) ethanedioate (1R,2R)-cyclohexane-1,2-diamine (1:1)
• NSC-266046
• [SP-4-2-(IR-trans)]-(1,2-cyclohexanediamine-n,n')[ethanedioato(2-)-O,O']-platinum
• (1R,2R)-cyclohexane-1,2-diamine: oxalic acid: platinum(+2) cation
• xalatoplatinum
• (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]platinum
• Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN,κN′][ethanedioato(2-)-κO1,κO2]-, (SP-4-2)-
• latin
• cyclohexane-1,2-diamine: oxalic acid: platinum
• RP-54780
• (sp-4-2)-((1r,2r)-1,2-cyclohexanediamine-n,n')(ethanedioato(2-)-O,O']platinum
• Platinum, (1,2-cyclohexanediamine-N,N′)[ethanedioato(2-)-O,O′]-, [SP-4-2-(1R-trans)]-
• platinum(4+) cyclohexane-1,2-diyldiazanide ethanedioate (1:1:1)
• Elocatin
• Oxalipatin
• trans-L-Diaminocyclohexane oxalatoplatinum
• 1,2-Cyclohexanediamine, platinum complex, (1R-trans)-
• ι-OHP
• [SP-4-2-(1R-trans)]-(1，2-Cyclohexanediamine-N，N，)[ethanedioato(2-)-O，O’Jplatinum
• OXALIPLATIN
• OXALIPIATIN
• Lipoxal
• SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N)[ETHANEDIOATO(2-)-O,OPT
• Oxaliplatin(Eloxatin)
• NSC-266046：Elocatin
• Eloxatin
• Cis-[(1R,2R)-1,2-cyclothexanediammine-N,N`][oxalato(2-)-O,O`]platinum
• Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
• P-54780
• oxalatoplatinum
• [SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N')[ETHANEDIOATA(2-)-O,O']PLATINUM
• oxaliplatino
• Oxaliplatin (125 mg)
• platinuM(2+) ion (1R,2R)-cyclohexane-1,2-diaMine oxalate
• oxalatoplatin
• Oxaliplatin EP/BP
• (1R-trans)-1,2-Cyclohexanediamine, platinum complex
• [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N
• 1-ohp
• (1,2-cyclohexanediamine-n,n’)(ethanedioato(2-)-o,o’)-platinu(sp-4-2-(1r-tr
• OxaliplatinEp5
• Dacplat
• Elplat
• OXALIPLATIN (oxaliplatin)
• oxalato(1r,2r-cyclohexanediammine)platinum(ii)
• [SP-4-2-（1R-trans）]-(1,2-Cyclohexanediamine-N,Nˊ)[ethanedioato(2-)-O,Oˊ]platinum
• (trans-1,2-Cyclohexanediamine)oxalatoplatinum(II)
• Oxaliplatin99%
• Oxaliplatin API

Oxaliplatin

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Color and Shape: White to Almost white powder to crystal

Molecular weight: 397.29

Ref: 3B-O0372

OXALIPLATIN CRS

CAS: 61825-94-3

OXALIPLATIN CRS

Formula: C₈H₁₂N₂O₄Pt

Molecular weight: 395.2759

Ref: 41-Y0000271

Oxaliplatin

CAS: 61825-94-3

Inorganic or organic compounds of precious metals, whether or not chemically defined, or amalgams of precious metals, nesoi

Formula: C₈H₁₄N₂O₄Pt

Color and Shape: White Off-White Powder

Molecular weight: 397.06015

Ref: 45-1481204

Trans-L-Diaminocyclohexane Oxalatoplatinum

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Purity: 98%

Color and Shape: Solid

Molecular weight: 397.2858

Ref: IN-DA0035Q1

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis.

Formula: C₈H₁₄N₂O₄Pt

Purity: 97% - 99.93%

Color and Shape: Solid

Molecular weight: 397.29

Ref: TM-T0164

Oxaliplatin

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Purity: 98.0 - 102.0 % (dried basis)

Color and Shape: White to almost white crystalline powder

Molecular weight: 397.29

Ref: 7W-GP0792

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin

Purity: ≥95%

Molecular weight: 397.29g/mol

Ref: 54-BUP16056

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin

Formula: C₈H₁₄N₂O₄Pt

Purity: 98%

Color and Shape: white solid

Molecular weight: 397.29g/mol

Ref: 54-BISN0119

Oxaliplatin

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Color and Shape: White To Off-White Solid

Molecular weight: 397.29

Ref: 4Z-O-242

Oxaliplatin, EP grade

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Molecular weight: 397.29

Ref: 7W-GP9874

Oxaliplatin

Controlled Product

CAS: 61825-94-3

Formula: C₈H₁₄N₂O₄Pt

Color and Shape: Neat

Molecular weight: 397.29

Ref: 86-MM0921.00

Oxaliplatin RS

CAS: 61825-94-3

Color and Shape: White Solid Crystalline Powder

Ref: 2K-1032100021

Oxaliplatin

Controlled Product

CAS: 61825-94-3

Applications Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),

Formula: C₈H₁₄N₂O₄Pt

Color and Shape: White To Off-White

Molecular weight: 397.29

Ref: TR-O845075

Oxaliplatin - Bio-X ™

CAS: 61825-94-3

Oxaliplatin is a platinum-based DNA-cross-linking agent. It is a chemotherapeutic drug, often used in combination with leucovorin, fluorouracil, and capecitabine. Oxaliplatin works by cross-linking DNA thus inhibiting the synthesis of RNA and proteins, which leads to cell death and inhibition of cancer cells growth. It is more effective than cisplatin or irinotecan in treating metastatic cancer. Oxaliplatin also has effects on Toll-like receptor 4 (TLR4) expression levels in vitro and in vivo models. In addition, oxaliplatin's effect on ATP binding cassette transporter proteins may be responsible for its antitumour activity against solid tumours.
Oxaliplatin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₈H₁₄N₂O₄Pt

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 397.29 g/mol

Ref: 3D-BO164182

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin is a platinum-based DNA-cross-linking agent. It is a chemotherapeutic drug, often used in combination with leucovorin, fluorouracil, and capecitabine. Oxaliplatin works by cross-linking DNA thus inhibiting the synthesis of RNA and proteins, which leads to cell death and inhibition of cancer cells growth. It is more effective than cisplatin or irinotecan in treating metastatic cancer. Oxaliplatin also has effects on Toll-like receptor 4 (TLR4) expression levels in vitro and in vivo models. In addition, oxaliplatin's effect on ATP binding cassette transporter proteins may be responsible for its antitumour activity against solid tumours.

Formula: C₈H₁₄N₂O₄Pt

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 397.29 g/mol

Ref: 3D-FD26607

Oxaliplatin

CAS: 61825-94-3

Purity: 98%

Molecular weight: 397.06

Ref: 10-F556520