CAS 61861-88-9

1H-Indole, 3-methyl-5-nitro-

Description:

1H-Indole, 3-methyl-5-nitro- is an organic compound characterized by its indole structure, which consists of a fused benzene and pyrrole ring. The presence of a methyl group at the 3-position and a nitro group at the 5-position contributes to its unique chemical properties. This compound typically appears as a yellow to orange crystalline solid and is known for its aromatic characteristics, which can influence its reactivity and interactions with other substances. It is soluble in organic solvents but has limited solubility in water. The nitro group is a strong electron-withdrawing group, which can affect the compound's reactivity, making it a potential candidate for various chemical reactions, including electrophilic substitutions. Additionally, 1H-Indole, 3-methyl-5-nitro- may exhibit biological activity, making it of interest in pharmaceutical research. Safety data should be consulted, as nitro compounds can be hazardous and may require careful handling. Overall, this compound is significant in both synthetic organic chemistry and potential applications in medicinal chemistry.

Formula: C₉H₈N₂O₂

3-Methyl-5-nitro-1H-indole

CAS: 61861-88-9

Formula: C₉H₈N₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 176.1720

Ref: IN-DA00F4ZK

3-Methyl-5-nitro-1H-indole

CAS: 61861-88-9

3-Methyl-5-nitro-1H-indole

Purity: 98%

Molecular weight: 176.17g/mol

Ref: 54-OR85577

3-Methyl-5-nitro-1H-indole

CAS: 61861-88-9

Purity: 98%

Molecular weight: 176.1750031

Ref: 10-F762277

3-Methyl-5-nitro-1H-indole

CAS: 61861-88-9

3-Methyl-5-nitro-1H-indole is a potent inhibitor of rifampicin, which is an antibiotic used to treat tuberculosis. 3-Methyl-5-nitro-1H-indole inhibits the growth of bacteria by binding to the 50S ribosomal subunit. It does not show any bactericidal activity in vitro and has been found to be ineffective in mice with chronic infections. 3-Methyl-5-nitro-1H-indole binds to the 50S ribosomal subunit and prevents the formation of antibiotic–ribosome complexes that are needed for bacterial protein synthesis. This drug also has pharmacokinetic properties that have been optimized for oral administration in humans. 3methyl 5 nitro 1H indole targets enzymes involved in DNA replication and transcription, such as bacterial gyrase, dna topoisomerase, and RNA polymerase.

Formula: C₉H₈N₂O₂

Purity: Min. 95%

Molecular weight: 176.17 g/mol

Ref: 3D-LCA86188