CAS 6190-39-2
:Dihydroergotamine mesylate
Description:
Dihydroergotamine mesylate is a semi-synthetic derivative of ergot alkaloids, primarily used in the treatment of migraine headaches and cluster headaches. It acts as a vasoconstrictor, targeting serotonin receptors to alleviate headache symptoms. The substance is typically administered via intranasal or intravenous routes, allowing for rapid onset of action. Dihydroergotamine mesylate is characterized by its relatively low solubility in water, which can affect its formulation and delivery methods. The mesylate salt form enhances its stability and bioavailability. Common side effects may include nausea, dizziness, and potential cardiovascular effects due to its vasoconstrictive properties. It is contraindicated in patients with certain cardiovascular conditions and should be used cautiously in those with a history of hypertension. As with all medications, it is essential to follow dosing guidelines and monitor for adverse reactions. Overall, dihydroergotamine mesylate is a valuable therapeutic agent in the management of acute migraine attacks, offering relief for many patients when used appropriately.
Formula:C33H37N5O5·CH4O3S
InChI:InChI=1S/C33H37N5O5.CH4O3S/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32;1-5(2,3)4/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39);1H3,(H,2,3,4)/t21-,23-,25-,26+,27+,32-,33+;/m1./s1
InChI key:InChIKey=ADYPXRFPBQGGAH-UMYZUSPBSA-N
SMILES:O[C@@]12N([C@@H](CC3=CC=CC=C3)C(=O)N4[C@]1(CCC4)[H])C(=O)[C@@](NC(=O)[C@@H]5C[C@@]6(C=7C=8C(C[C@]6(N(C)C5)[H])=CNC8C=CC7)[H])(C)O2.S(C)(=O)(=O)O
Synonyms:- (2'Ξ,5'Α,12'Ξ)-5'-Benzyl-12'-Hydroxy-2'-Methyl-3',6',18-Trioxo-9,10-Dihydroergotaman Methanesulfonate (Salt)
- (5'Alpha)-5'-Benzyl-12'-Hydroxy-2'-Methyl-3',6',18-Trioxo-9,10-Dihydroergotaman Methanesulfonate (Salt)
- (5'Alpha,10Alpha)-5'-Benzyl-12'-Hydroxy-2'-Methyl-3',6',18-Trioxo-9,10-Dihydroergotaman Methanesulfonate (1:1)
- 9,10-Dihydroergotamine mesylate
- Agit
- Angionorm
- Dergotamine
- Detms
- Dhe 45
- Diergo
- Dihydergot
- Dihydroergotamine Mesilate
- Dihydroergotamine Methanesulfonate
- Dihydroergotamine methanesulphonate
- Dihydroergotamine monomethanesulfonate
- Dihydroergotaminmesilat
- Dihytamine
- Dirgotarl
- Endophleban
- Ergomimet
- Ergont
- Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'α,10α)-, methanesulfonate (1:1)
- Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'α,10α)-, monomethanesulfonate (salt)
- Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)-, (5′α,10α)-, methanesulfonate (1:1)
- Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)-, (5′α,10α)-, monomethanesulfonate (salt)
- Ergotamine, 9,10-dihydro-, monomethanesulfonate (salt)
- Ergotonin
- Ikaran
- Mesilate De Dihydroergotamine
- Mesilato De Dihidroergotamina
- Migranal
- Morena
- Orstanorm
- Seglor
- Tonopres
- Verladyn
- (2'ξ,5'α,12'ξ)-5'-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman methanesulfonate (salt)
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 12 products.
Dihydroergotamine methanesulfonate
CAS:<p>Agonist at vascular serotonin receptors; partial agonist at alpha-adrenergic and dopamine D2 receptors This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aes</p>Formula:C34H41N5O8SColor and Shape:Powder or crystals or crystalline powder, White to pale yellow to pale redMolecular weight:679.79DIHYDROERGOTAMINE MESILATE CRS
CAS:<p>DIHYDROERGOTAMINE MESILATE CRS</p>Formula:C34H41N5O8SColor and Shape:Crystalline Powder. White. Colourless Crystals. Powder.Molecular weight:679.783DIHYDROERGOTAMINE FOR PEAK IDENTIFICATION CRS
CAS:<p>DIHYDROERGOTAMINE FOR PEAK IDENTIFICATION CRS</p>Formula:C34H41N5O8SMolecular weight:679.783Dihydroergotamine Mesylate
CAS:Alkaloids of rye ergot and their derivatives; salts thereof, nesoiFormula:C33H37N5O5·CH4O3SColor and Shape:White Off-White PowderMolecular weight:679.26758Dihydroergotamine methanesulfonate salt
CAS:Formula:C33H37N5O5·CH4O3SColor and Shape:White to pale-yellow or pale-red powder or crystalsMolecular weight:679.78Dihydroergotamine Mesylate
CAS:Formula:C33H37N5O5·CH4O3SPurity:>97.0%(HPLC)Color and Shape:White to Light yellow to Light red powder to crystalMolecular weight:679.79Dihydroergotamine Mesylate
CAS:Controlled Product<p>Applications α-Androgenic blocker with selective venoconstrictor properties. Also binds to serotonin 5HT1-receptors. Antimigraine.<br>References de Marees, et al.: Eur. J. Clin. Pharmacol., 30, 685 (1986), McCarthy, B.G., et al.: Headache, 29, 420 (1989), Ziegler, D., et al.: Neurology, 44, 447 (1994),<br></p>Formula:C33H37N5O5·CH4O3SColor and Shape:White To Off-WhiteMolecular weight:679.78Dihydro ergotamine mesylate
CAS:Controlled Product<p>Dihydroergotamine mesylate is a medication that is used in the treatment of migraines. It belongs to the group of drugs called ergot alkaloids and has been shown to have high values in cerebral metabolism. Dihydroergotamine mesylate has also been shown to have an effect on dopamine levels in human serum, which may be due to its ability to inhibit neuronal death. Dihydroergotamine mesylate is administered intravenously, orally or intramuscularly for the treatment of acute migraine attacks. The drug can also be given rectally for the prevention of chronic migraine episodes. This drug may cause side effects such as nausea, vomiting and dizziness.</p>Formula:C34H41N5O8SPurity:Min. 95%Color and Shape:PowderMolecular weight:679.78 g/molDihydroergotamine mesylate
CAS:Controlled ProductFormula:C33H37N5O5·CH4O3SColor and Shape:NeatMolecular weight:679.78
