CAS 61966-08-3

Triciribine phosphate

Description:

Triciribine phosphate, with the CAS number 61966-08-3, is a synthetic compound that belongs to the class of nucleoside analogs. It is primarily recognized for its potential as an antiviral and anticancer agent. The substance functions by inhibiting certain cellular pathways, particularly those involving protein kinases, which are crucial for cell proliferation and survival. Triciribine phosphate is often studied for its effects on various cancer cell lines and its ability to enhance the efficacy of other therapeutic agents. In terms of physical properties, it is typically presented as a white to off-white powder, soluble in water and other polar solvents. Its stability and reactivity can be influenced by environmental factors such as pH and temperature. Safety data indicates that, like many pharmaceutical compounds, it should be handled with care, as it may pose risks if ingested or improperly managed. Overall, triciribine phosphate represents a significant area of research in the fields of oncology and virology, with ongoing studies aimed at elucidating its full therapeutic potential.

Formula: C₁₃H₁₇N₆O₇P

InChI: InChI=1S/C13H17N6O7P/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(21)8(20)6(26-13)3-25-27(22,23)24/h2,4,6,8-9,13,20-21H,3H2,1H3,(H2,14,17)(H2,22,23,24)/t6-,8-,9-,13-/m1/s1

InChI key: InChIKey=URLYINUFLXOMHP-HTVVRFAVSA-N

SMILES: NC=1C=2C=3C(N(C2)[C@@H]4O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]4O)=NC=NC3N(C)N1

Synonyms:

• 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-
• 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-
• 1,4,5,6,8-Pentaazaacenaphthylene-3-amino-1,5-dihydro-5-methyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl 5′-monophosphate
• 1,5-Dihydro-5-methyl-1-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-1,4,5,6,8-pentaazaacenaphthylen-3-amine
• 3-Amino-1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylene 5'-(dihydrogen phosphate)
• 5-methyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
• 5-methyl-1-(5-O-phosphonopentofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
• Nsc 280594
• Pentaazaacenaphthylene-5' phosphate ester
• Tcn-P
• Triciribine phosphate [USAN]
• Unii-5L5Ge3Dv88
• Vqd 002
• 1,4,5,6,8-Pentaazaacenaphthylene-3-amino-1,5-dihydro-5-methyl-1-β-D-ribofuranosyl 5′-monophosphate
• 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-
• Triciribine phosphate

Triciribine phosphate

CAS: 61966-08-3

Triciribine phosphate

Purity: ≥95%

Molecular weight: 400.28g/mol

Ref: 54-BUP00595

Tricirbine Phosphate

CAS: 61966-08-3

Formula: C₁₃H₁₇N₆O₇P

Molecular weight: 400.29

Ref: 4Z-T-166002

Tricirbine Phosphate -13C5

CAS: 61966-08-3

Formula: C₅C₈H₁₇N₆O₇P

Molecular weight: 405.23

Ref: 4Z-T-166004

Tricyclic nucleoside phosphate

CAS: 61966-08-3

Akt activation inhibitor

Formula: C₁₃H₁₇N₆O₇P

Purity: Min. 95%

Molecular weight: 400.28 g/mol

Ref: 3D-NT44794

Triciribine phosphate

Controlled Product

CAS: 61966-08-3

Applications Triciribine phosphate is an Akt activation inhibitor that inhibits Akt phosphorylation by binding to the pleckstrin homology (PH) domain of the Akt and blocking its recruitment to the plasma membrane.
References Berndt, N., et al.: Cell Death Differ. 17, 1795 (2010)

Formula: C₁₃H₁₇N₆O₇P

Color and Shape: Neat

Molecular weight: 400.284

Ref: TR-T779400

Triciribine phosphate

CAS: 61966-08-3

Triciribine phosphate (VD 002) is an AKT inhibitor that inhibits neovascularization and can be used in the study of leukemia.

Formula: C₁₃H₁₇N₆O₇P

Purity: 97.94%

Color and Shape: Solid

Molecular weight: 400.28

Ref: TM-T19699