CAS 62010-37-1

Ganglioside GD3

Description:

Ganglioside GD3 is a glycosphingolipid, a type of molecule that plays a crucial role in cell membrane structure and function. It is characterized by its complex carbohydrate structure, which includes sialic acid, contributing to its negative charge at physiological pH. GD3 is primarily found in the nervous system and is involved in various biological processes, including cell signaling, cell recognition, and modulation of immune responses. This ganglioside is particularly significant in the context of neuronal development and differentiation. Additionally, GD3 has been studied for its role in certain pathological conditions, including cancer, where it may influence tumor progression and immune evasion. Its presence on the surface of cells can also serve as a marker for specific cell types, making it of interest in both diagnostic and therapeutic applications. Overall, GD3 exemplifies the intricate interplay between lipid composition and cellular function in biological systems.

Formula: Unspecified

Synonyms:

• Disialosyllactosylceramide
• G(D3) Ganglioside
• G_D3
• GD3
• GD3 Ganglioside
• Ganglioside D3
• Ganglioside D₃
• Ganglioside G_D3
• Ganglioside, GD3
• Gd(3)
• N-Acetylneuraminyl N-acetylneuraminylgalactosylglucosylceramide

Ganglioside GD3 Mixture (sodium salt)

CAS: 62010-37-1

Ganglioside GD3, precursor to complex gangliosides, induces apoptosis and alters mitochondrial potential; affects cell growth, invasion, and neurogenesis.

Formula: C₇₀H₁₂₃N₃Na₂O₂₉

Color and Shape: Solid

Molecular weight: 1516.726

Ref: TM-T35552

Disialoganglioside GD3

CAS: 62010-37-1

Formula: Unspecified

Purity: >98%

Color and Shape: Solid

Ref: 48-56-1201

GD3-Ganglioside

CAS: 62010-37-1

Formula: C₇₀H₁₂₃N₃O₂₉·2Na

Purity: ≥ 95%

Color and Shape: White to faint yellow powder

Molecular weight: 1516.80

Ref: 7W-GC7995

GD3-Ganglioside sodium

CAS: 62010-37-1

GD3 (shown as sodium salt) has a core disaccharide structure (Galβ1,4Glc) with two sialic acids linked α2,3/α2,8 to the non-reducing galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD3 is a minor ganglioside in most normal tissues but plays a crucial role in the development of the brain; it is significantly reduced in adults. However, expression of GD3 is increased in pathological conditions, such as, cancers and neurodegenerative disorders (Malisan, 2002). GD3 was the first cancer-associated ganglioside discovered that promotes adhesion and invasion of cancers. GD3 and GD2 are highly expressed in a various malignant tumours and have become potential targets for next-generation cancer therapy (Liu, 2018).

Formula: C₇₀H₁₂₅N₃O₂₉·xNa

Purity: One Spot

Color and Shape: White/Off-White Solid

Molecular weight: 1,472.74 g/mol

Ref: 3D-OG03922

GD3-Ganglioside ammonium

CAS: 62010-37-1

GD3 ganglioside (shown as sodium salt) has a core disaccharide structure (Gal-1,4-Glc) with two sialic acids linked to the non-reducing galactose residue, and ceramide linked to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD3 ganglioside is a minor ganglioside in most normal tissues but plays a crucial role in the development of the brain; its presence is significantly reduced in adults. However, expression of GD3 ganglioside is increased in pathological conditions, such as, cancers and neurodegenerative disorders (Malisan, 2002). GD3 ganglioside was the first cancer-associated ganglioside discovered, that promotes adhesion and invasion of cancers. GD3 ganglioside and GD2 ganglioside are highly expressed in a various malignant cancers and have become potential targets for next-generation cancer therapy (Liu, 2018).

Formula: C₇₀H₁₂₅N₃O₂₉·xNH₄

Purity: Min. 95%

Color and Shape: Powder

Ref: 3D-OG175971