CAS 62013-04-1

Dirithromycin

Description:

Dirithromycin is a macrolide antibiotic that is primarily used to treat various bacterial infections. It is characterized by its ability to inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing the growth and reproduction of bacteria. Dirithromycin is known for its broad-spectrum activity against both Gram-positive and some Gram-negative bacteria, making it effective in treating respiratory tract infections, skin infections, and certain sexually transmitted diseases. The compound is typically administered orally and is well-absorbed in the gastrointestinal tract. Its pharmacokinetics include a relatively long half-life, allowing for once-daily dosing in many cases. Dirithromycin is also notable for its favorable safety profile, with fewer gastrointestinal side effects compared to some other antibiotics in its class. However, like all antibiotics, it is essential to use dirithromycin judiciously to prevent the development of antibiotic resistance. Overall, dirithromycin represents a valuable option in the arsenal of antimicrobial therapies.

Formula: C₄₂H₇₈N₂O₁₄

InChI: InChI=1S/C42H78N2O14/c1-15-29-42(10,49)37-24(4)32(43-30(56-37)21-52-17-16-50-13)22(2)19-40(8,48)36(58-39-33(45)28(44(11)12)18-23(3)53-39)25(5)34(26(6)38(47)55-29)57-31-20-41(9,51-14)35(46)27(7)54-31/h22-37,39,43,45-46,48-49H,15-21H2,1-14H3/t22-,23-,24+,25+,26-,27+,28+,29-,30-,31+,32+,33-,34+,35+,36-,37-,39+,40-,41-,42-/m1/s1

InChI key: InChIKey=WLOHNSSYAXHWNR-DWIOZXRMSA-N

SMILES: C[C@@H]1[C@]2(O[C@H](COCCOC)N[C@]1([C@H](C)C[C@@](C)(O)[C@H](O[C@H]3[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@@H](C)[C@H](O[C@H]4C[C@](OC)(C)[C@@H](O)[C@H](C)O4)[C@@H](C)C(=O)O[C@H](CC)[C@@]2(C)O)[H])[H]

Synonyms:

• (1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-7-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</smallcap>-ribo-hexopyranosyl)oxy]-3-ethyl-2,10-dihydroxy-15-[(2-methoxyethoxy)methyl]-2,6,8,10,12,17-hexamethyl-9-[[3,4,6-trideoxy-3-(dimethylamino)-β-<smallcap>D</span>-xylo-hexopyranosyl]oxy]-4,16-dioxa-14-azabicyclo[11.3.1]heptadecan-5-one
• (2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-3-ethyl-2,10-dihydroxy-15-[(2-methoxyethoxy)methyl]-2,6,8,10,12,17-hexamethyl-5-oxo-9-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-4,16-dioxa-14-azabicyclo[11.3.1]heptadec-7-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside
• 3-ethyl-2,10-dihydroxy-15-[(2-methoxyethoxy)methyl]-2,6,8,10,12,17-hexamethyl-5-oxo-9-{[3,4,6-trideoxy-3-(dimethylamino)hexopyranosyl]oxy}-4,16-dioxa-14-azabicyclo[11.3.1]heptadec-7-yl 2,6-dideoxy-3-C-methyl-3-O-methylhexopyranoside
• 4,16-Dioxa-14-azabicyclo[11.3.1]heptadecan-5-one, 7-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</smallcap>-ribo-hexopyranosyl)oxy]-3-ethyl-2,10-dihydroxy-15-[(2-methoxyethoxy)methyl]-2,6,8,10,12,17-hexamethyl-9-[[3,4,6-trideoxy-3-(dimethylamino)-β-<smallcap>D</span>-xylo-hexopyranosyl]oxy]-, (1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-
• 4,16-Dioxa-14-azabicyclo[11.3.1]heptadecane, erythromycin deriv.
• Antibiotic AS-E 136
• Ase 136
• DRM
• Dirithomycin
• Dirythromycin
• Dynabac
• Erythromycin, 9-deoxo-11-deoxy-9,11-[imino[2-(2-methoxyethoxy)ethylidene]oxy]-, [9S(R)]-
• Kt 237216
• Ly 237216
• Noriclan
• Nortron
• Valodin
• 4,16-Dioxa-14-azabicyclo[11.3.1]heptadecan-5-one, 7-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-3-ethyl-2,10-dihydroxy-15-[(2-methoxyethoxy)methyl]-2,6,8,10,12,17-hexamethyl-9-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-

Dirithromycin

CAS: 62013-04-1

Formula: C₄₂H₇₈N₂O₁₄

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 835.09

Ref: 3B-D5495

DIRITHROMYCIN CRS

CAS: 62013-04-1

DIRITHROMYCIN CRS

Formula: C₄₂H₇₈N₂O₁₄

Color and Shape: White. Whitish. Powder.

Molecular weight: 835.0737

Ref: 41-D2880000

Dirithromycin

CAS: 62013-04-1

Dirithromycin (LY237216), a macrolide antibiotic, treats bacterial infections like bronchitis and pneumonia.

Formula: C₄₂H₇₈N₂O₁₄

Purity: 98% - 98.89%

Color and Shape: Crystals

Molecular weight: 835.07

Ref: TM-T0971

Dirithromycin

CAS: 62013-04-1

Formula: C₄₂H₇₈N₂O₁₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 835.0737

Ref: IN-DA019FVM

Dirithromycin-13C-d3

CAS: 62013-04-1

Formula: CC₄₁H₇₅D₃N₂O₁₄

Color and Shape: White To Off-White Solid

Molecular weight: 839.10

Ref: 4Z-D-106002

Dirithromycin

CAS: 62013-04-1

Dirithromycin

Purity: ≥98%

Molecular weight: 835.07g/mol

Ref: 54-BUP18779

Dirithromycin

CAS: 62013-04-1

Formula: C₄₂H₇₈N₂O₁₄

Color and Shape: White To Off-White Solid

Molecular weight: 835.09

Ref: 4Z-D-106001

Dirithromycin

CAS: 62013-04-1

Dirithromycin

Purity: 98%

Molecular weight: 835.07g/mol

Ref: 54-OR1029607

Dirithromycin

CAS: 62013-04-1

Formula: C₄₂H₇₈N₂O₁₄

Molecular weight: 835.07

Ref: 7W-GA7887

Dirithromycin

Controlled Product

CAS: 62013-04-1

Applications Semi-synthetic derivative of Erythromycin. Antibacterial.
References Firl, J., et al.: J. Antibiot., 43, 1271 (1990), Counter, et al.: Antimicrob. Agents Chemother., 35, 1116 (1991), Castaldo, R., et al.: Clin. Ther., 25, 542 (2003),

Formula: C₄₂H₇₈N₂O₁₄

Color and Shape: Off-White

Molecular weight: 835.07

Ref: TR-D493000

Dirithromycin

CAS: 62013-04-1

Dirithromycin is a macrolide glycopeptide antibiotic with action on bacterial protein synthesis inhibition and is used for treating respiratory, skin, and other bacterial infections.

Formula: C₄₂H₇₈N₂O₁₄

Purity: Min. 95%

Molecular weight: 835.07 g/mol

Ref: 3D-AD16702

Dirithromycin-d3

Controlled Product

CAS: 62013-04-1

Formula: C₄₂D₃H₇₅N₂O₁₄

Color and Shape: Neat

Molecular weight: 838.092

Ref: TR-D493002

Dirithromycin (DISCONTINUED)

CAS: 62013-04-1

Erythromycin and its derivatives; salts thereof

Formula: C₄₂H₇₈N₂O₁₄

Color and Shape: Powder

Molecular weight: 834.54531

Ref: 45-1220700