CAS 621-44-3

Nitrotyrosine

Description:

Nitrotyrosine is a modified amino acid that arises from the nitration of the amino acid tyrosine, typically through the action of reactive nitrogen species, such as peroxynitrite. It is characterized by the presence of one or more nitro groups (-NO2) attached to the aromatic ring of the tyrosine molecule. This modification can significantly alter the biochemical properties of the protein in which it is incorporated, affecting protein function, stability, and interactions. Nitrotyrosine is often used as a biomarker for oxidative stress and inflammation, as its formation is associated with various pathological conditions, including neurodegenerative diseases and cardiovascular disorders. In terms of solubility, nitrotyrosine is generally soluble in water and polar solvents, which facilitates its detection and quantification in biological samples. Its presence can be assessed using techniques such as mass spectrometry and immunohistochemistry, making it a valuable tool in research and clinical diagnostics. Overall, nitrotyrosine serves as an important indicator of oxidative damage and cellular response to stress.

Formula: C₉H₁₀N₂O₅

InChI: InChI=1S/C9H10N2O5/c10-6(9(13)14)3-5-1-2-8(12)7(4-5)11(15)16/h1-2,4,6,12H,3,10H2,(H,13,14)/t6-/m0/s1

InChI key: InChIKey=FBTSQILOGYXGMD-LURJTMIESA-N

SMILES: C([C@@H](C(O)=O)N)C1=CC(N(=O)=O)=C(O)C=C1

Synonyms:

• (2S)-2-Amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid
• (2S)-2-Azaniumyl-3-(4-hydroxy-3-nitrophenyl)propanoate
• (2S)-2-ammonio-3-(3-nitro-4-oxidophenyl)propanoate
• 210-688-6
• 3-Nitro-<span class="text-smallcaps">L</span>-tyrosine
• 3-Nitro-L-tyrosin
• 3-Nitrotyrosine
• 3-nitro-D-tyrosine
• 3-nitro-L-tirosina
• 3: PN: WO2005055810 PAGE: 59 claimed protein
• <span class="text-smallcaps">L</span>-Tyrosine, 3-nitro-
• H-Tyr(3-NO2)-OH
• L-Tyrosine, 3-nitro-
• Nitrotyrosine
• Nsc 37413
• Tyrosine, 3-nitro-, <span class="text-smallcaps">L</span>-
• Tyrosine, 3-nitro-, L-
• Tyrosine, 3-nitro-, L- (8CI)
• 3-Nitro-L-tyrosine
• H-M-NITRO-TYR-OH
• H-3-NITRO-TYR-OH
• 3-NITRO-4-HYDROXY-PHENYLALANINE
• 3-Nitro-L-tyrosine 99%
• (2R)-2-Amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid
• Tyr(3'-NO2)
• H-4-HYDROXY-3-NITRO-PHE-OH
• H-TYR(M-NO2)-OH
• M-NITRO-L-TYROSINE
• 3-NITRO-TYROSINEH-TYR(3-NO2)-OH
• 3-NITRO-TYROSINE

H-Tyr(3-NO2)-OH

CAS: 621-44-3

Formula: C₉H₁₀N₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 226.1861

Ref: IN-DA003JTF

3-Nitro-L-tyrosine

CAS: 621-44-3

3-Nitro-L-tyrosine

Purity: ≥98%

Molecular weight: 226.19g/mol

Ref: 54-BUP18549

3-Nitro-L-tyrosine

CAS: 621-44-3

3-Nitro-L-tyrosine

Purity: 98%

Color and Shape: Solid

Molecular weight: 226.19g/mol

Ref: 54-OR9954

3-Nitro-L-tyrosine crystalline

CAS: 621-44-3

Formula: C₉H₁₀N₂O₅

Molecular weight: 226.19

Ref: 7W-GM4161

3-Nitro-L-tyrosine

CAS: 621-44-3

Formula: C₉H₁₀N₂O₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Amber powder to crystal

Molecular weight: 226.19

Ref: 3B-N0905

3-Nitro-L-tyrosine

CAS: 621-44-3

3-Nitro-L-tyrosine

Purity: 98%

Molecular weight: 226.19g/mol

Ref: 54-BIB6250

3-Nitro-L-tyrosine

CAS: 621-44-3

3-Nitrotyrosine forms when peroxynitrite reacts with tyrosine, indicating NO-related oxidative damage.

Formula: C₉H₁₀N₂O₅

Purity: 98.94%

Color and Shape: Solid

Molecular weight: 226.19

Ref: TM-T4890

3-Nitro-L-tyrosine

CAS: 621-44-3

Applications A marker for peroxynitrite. Oxidant and cytotoxic agent.
References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),

Formula: C₉H₁₀N₂O₅

Color and Shape: Off White Crystalline

Molecular weight: 226.19

Ref: TR-N597000

3-Nitro-L-tyrosine

CAS: 621-44-3

3-Nitro-L-tyrosine is an oxidized form of L-tyrosine that is a byproduct of lipid peroxidation. 3-Nitro-L-tyrosine has been detected in the blood and cerebrospinal fluid of patients with bowel disease, which may be due to oxidative injury. The formation of 3-nitrotyrosine is associated with neuronal death in neurodegenerative diseases. Analysis of 3-nitrotyrosine has shown the presence of nitrate and nitrite, which suggests that it may be involved in the pathogenic mechanism for atherosclerosis. This compound is also genotoxic, as shown by its ability to cause DNA strand breaks and DNA crosslinks.

Formula: C₉H₁₀N₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 226.19 g/mol

Ref: 3D-FN37133

3-Nitro-Tyrosine

CAS: 621-44-3

M03246 - 3-Nitro-Tyrosine

Formula: C₉H₁₀N₂O₅

Purity: 98%

Color and Shape: Solid, Crystalline

Molecular weight: 226.188

Ref: 10-M03246

3-Nitro-L-tyrosine, 98%

CAS: 621-44-3

3-Nitro-L-tyrosine is used as an indicator of the formation of peroxynitrite by NO-dependent oxidative damage. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original

Formula: C₉H₁₀N₂O₅

Purity: 98%

Color and Shape: Yellow, Powder

Molecular weight: 226.19

Ref: 02-A11018