CAS 622370-35-8

Tradipitant

Description:

Tradipitant is a small molecule compound primarily recognized for its role as a neurokinin-1 (NK1) receptor antagonist. It has garnered attention in the pharmaceutical industry for its potential therapeutic applications, particularly in the treatment of conditions such as anxiety and nausea. The chemical structure of Tradipitant features a distinct arrangement of atoms that contributes to its biological activity, specifically its ability to inhibit the binding of substance P to the NK1 receptor, which is implicated in various neurogenic processes. Tradipitant is characterized by its moderate lipophilicity, which influences its pharmacokinetic properties, including absorption and distribution within the body. Additionally, it has been studied for its safety profile and tolerability in clinical settings. As research continues, Tradipitant may offer insights into the management of disorders linked to the neurokinin system, highlighting the importance of NK1 receptor modulation in therapeutic strategies.

Formula: C₂₈H₁₆ClF₆N₅O

InChI: InChI=1S/C28H16ClF6N5O/c29-22-6-2-1-4-20(22)26(41)21-5-3-9-37-23(21)24-25(17-7-10-36-11-8-17)40(39-38-24)15-16-12-18(27(30,31)32)14-19(13-16)28(33,34)35/h1-14H,15H2

InChI key: InChIKey=CAVRKWRKTNINFF-UHFFFAOYSA-N

SMILES: C(N1C(=C(N=N1)C2=C(C(=O)C3=C(Cl)C=CC=C3)C=CC=N2)C=4C=CN=CC4)C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5

Synonyms:

• Tradipitant
• tradipitant
• VLY 686
• [2-[1-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-5-(4-pyridinyl)-1H-1,2,3-triazol-4-yl]-3-pyridinyl](2-chlorophenyl)methanone
• Methanone, [2-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-pyridinyl)-1H-1,2,3-triazol-4-yl]-3-pyridinyl](2-chlorophenyl)-
• [2-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-pyridinyl)-1H-1,2,3-triazol-4-yl]-3-pyridinyl](2-chlorophenyl)methanone
• [2-[1-[3,5-Bis(trifluoromethyl)benzyl]-5-(pyridin-4-yl)-1H-[1,2,3]triazol-4-yl]pyridin-3-yl](2-chlorophenyl)methanone
• tradipitant,VLY-686, LY686017
• LY686017
• Biafungin
• (2-(1-(3,5-Bis(trifluoromethyl)benzyl)-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)pyridin-3-yl)(2-
• VLY 686,LY-686017,Neurokinin Receptor,VLY686,LY 686017,Inhibitor,Tradipitant,NK receptor,Tachykinin receptor,inhibit
• VLY-686;LY686017
• Tradipitant, 10 mM in DMSO

Tradipitant

CAS: 622370-35-8

Formula: C₂₈H₁₆ClF₆N₅O

Purity: 97%

Color and Shape: Solid

Molecular weight: 587.9030

Ref: IN-DA00EK6I

(2-(1-(3,5-Bis(Trifluoromethyl)Benzyl)-5-(Pyridin-4-Yl)-1H-1,2,3-Triazol-4-Yl)Pyridin-3-Yl)(2-Chlorophenyl)Methanone

CAS: 622370-35-8

(2-(1-(3,5-Bis(Trifluoromethyl)Benzyl)-5-(Pyridin-4-Yl)-1H-1,2,3-Triazol-4-Yl)Pyridin-3-Yl)(2-Chlorophenyl)Methanone

Purity: 99%

Molecular weight: 587.9g/mol

Ref: 54-PC108634

Tradipitant

CAS: 622370-35-8

Tradipitant

Purity: ≥98%

Molecular weight: 587.9g/mol

Ref: 54-BUP05175

Tradipitant

CAS: 622370-35-8

Tradipitant is a neurokinin-1 receptor antagonist, which is a compound that targets a specific receptor involved in neurochemical signaling. Derived from synthetic chemical processes, Tradipitant specifically binds to the neurokinin-1 receptor, blocking the action of substance P, a neuropeptide associated with inflammation and pain pathways.

Formula: C₂₈H₁₆ClF₆N₅O

Purity: Min. 95%

Molecular weight: 587.9 g/mol

Ref: 3D-FT176211

Tradipitant

CAS: 622370-35-8

Tradipitant (VLY-686) is an antagonist of neurokinin-1.

Formula: C₂₈H₁₆ClF₆N₅O

Purity: 99.42%

Color and Shape: Solid

Molecular weight: 587.9

Ref: TM-T17156