CAS 622387-85-3

(3Z)-3-[(1-methyl-1H-indol-3-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide

Description:

The chemical substance known as (3Z)-3-[(1-methyl-1H-indol-3-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide, with the CAS number 622387-85-3, is characterized by its complex molecular structure, which includes indole and sulfonamide functional groups. This compound features a dihydroindole core, which contributes to its potential biological activity. The presence of the sulfonamide group suggests possible interactions with biological targets, making it of interest in medicinal chemistry. The indole moiety is known for its role in various pharmacological activities, including anti-cancer and anti-inflammatory properties. The compound's Z configuration indicates a specific geometric arrangement around the double bond, which can influence its reactivity and interactions with biological systems. Additionally, the presence of a ketone group enhances its potential for hydrogen bonding and reactivity. Overall, this compound's unique structural features may contribute to its efficacy in therapeutic applications, warranting further investigation into its biological properties and mechanisms of action.

Formula: C₁₈H₁₅N₃O₃S

InChI: InChI=1/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)/b15-8-

SMILES: Cn1cc(/C=C\2/c3cc(ccc3N=C2O)S(=O)(=O)N)c2ccccc12

Synonyms:

• 1H-indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-, (3Z)-
• 3-(1-Methylindol-3-ylmethylene)-2-oxo-2,3-dihydroindole-5-sulfonic acid amide
• 622387-85-3

Syk Inhibitor

CAS: 622387-85-3

Syk Inhibitor is a small molecule compound designed to inhibit the activity of spleen tyrosine kinase (Syk), which is derived through advanced chemical synthesis from a variety of organic substrates. With its mode of action as a kinase inhibitor, Syk Inhibitor functions by specifically binding to the ATP-binding site of the Syk enzyme. This binding effectively blocks the phosphorylation processes necessary for signal transduction pathways that are critical in immune cell activation and function.

Formula: C₁₈H₁₅N₃O₃S

Purity: Min. 95%

Molecular weight: 353.4 g/mol

Ref: 3D-XZA38785

OXSI-2

CAS: 622387-85-3

OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM.

Formula: C₁₈H₁₅N₃O₃S

Purity: 98%

Color and Shape: Dark Orange Solid

Molecular weight: 353.39

Ref: TM-T28281