CAS 62305-86-6

Orotirelin

Description:

Orotirelin, also known as TRH (thyrotropin-releasing hormone), is a tripeptide composed of three amino acids: pyroglutamic acid, histidine, and proline. It plays a crucial role in the regulation of the hypothalamic-pituitary-thyroid axis by stimulating the release of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. This, in turn, promotes the synthesis and release of thyroid hormones from the thyroid gland, which are essential for metabolism, growth, and development. Orotirelin is characterized by its relatively small molecular size and specific structural features that allow it to interact with its receptors effectively. It is often studied for its potential therapeutic applications in conditions related to thyroid dysfunction and has been investigated for its neuroprotective effects in various neurological disorders. Additionally, its CAS number, 62305-86-6, is a unique identifier that facilitates the cataloging and identification of this compound in chemical databases.

Formula: C₁₆H₁₉N₇O₅

InChI: InChI=1/C16H19N7O5/c17-13(25)11-2-1-3-23(11)15(27)10(4-8-6-18-7-19-8)20-14(26)9-5-12(24)22-16(28)21-9/h5-7,10-11H,1-4H2,(H2,17,25)(H,18,19)(H,20,26)(H2,21,22,24,28)/t10-,11-/m0/s1

InChI key: InChIKey=XZOCIZHAHWDUPU-QWRGUYRKSA-N

SMILES: C([C@H](CC1=CN=CN1)NC(=O)C2=CC(=O)NC(=O)N2)(=O)N3[C@H](C(N)=O)CCC3

Synonyms:

• 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarbonyl-<span class="text-smallcaps">L</smallcap>-histidyl-<smallcap>L</span>-prolinamide
• <span class="text-smallcaps">L</smallcap>-Prolinamide, 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarbonyl-<smallcap>L</span>-histidyl-
• <span class="text-smallcaps">L</smallcap>-Prolinamide, N-[(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinyl)carbonyl]-<smallcap>L</span>-histidyl-
• Brn 0730085
• Cg 3509
• L-Prolinamide, N-((1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinyl)carbonyl)-L-histidyl-
• N-((1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinyl)carbonyl)-L-histidyl-L-prolinamide
• N-[(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)carbonyl]-L-histidyl-L-prolinamide
• Orotirelin [INN]
• Orotirelina
• Orotirelina [Spanish]
• Orotireline
• Orotireline [French]
• Orotirelinum
• Orotirelinum [Latin]
• L-Prolinamide, 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-
• Orotirelin
• 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-L-prolinamide

Orotirelin

CAS: 62305-86-6

Orotirelin

Purity: ≥98%

Molecular weight: 389.37g/mol

Ref: 54-BUP00593

Orotirelin

Controlled Product

CAS: 62305-86-6

Formula: C₁₆H₁₉N₇O₅

Color and Shape: Neat

Molecular weight: 389.366

Ref: TR-O688515

Orotirelin

CAS: 62305-86-6

Orotirelin is a peptide that is used as a research tool and in the study of protein interactions. Orotirelin binds to orexin receptors, which are found in neurons of the hypothalamus, and activates them. It has been shown to have a potent inhibitory effect on the release of pituitary hormones from the anterior lobe of the pituitary gland. It also acts as an inhibitor for certain ion channels and can be used as an antibody against other ligands that bind to orexin receptors.

Formula: C₁₆H₁₉N₇O₅

Purity: Min. 95%

Molecular weight: 389.37 g/mol

Ref: 3D-MCA30586

Orotirelin

CAS: 62305-86-6

Orotirelin (CG 3509), a TRH analog, counters pentobarbital sleep; may aid in cerebral ischemia.

Formula: C₁₆H₁₉N₇O₅

Purity: 98.92%

Color and Shape: Solid

Molecular weight: 389.37

Ref: TM-T33824